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The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用,阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制,我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响;以Lewis肺癌自发性转移为模型,考察了托吡酯对肿瘤生长和转移的影响;同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响;检测了其对血管新生的作用;利用体外AQP1表达模型,研究了CA抑制剂对AQP1功能的影响;此外,用蛋白质组学的关键技术,通过对模型组与托吡酯治疗组血清蛋白质组的比较分析,来寻找与肿瘤转移相关的蛋白质,探索托吡酯的可能作用靶点。

In fact, The Sundering, or the world event in Azeroth's history where the Well of Eternity was destroyed and the Maelstrom (that swirly thing in the middle of the map) was created, was referred to as "the Cataclysm."

事实上, the sundering(指的就是永恒之井被摧毁的事,当然也许是精灵语的说法),或者是艾泽拉斯大陆的历史上永恒之井被摧毁的事件,使得大漩涡(地图中间那团漩涡状的东西)诞生了,就是那个东西指的就是大漩涡。

Thad Brown: They wanted to be associated with the team because they could in fact not only create a 8beachhead here in the United States for the distribution of their product, but also it would reach their customers back in China while the games are being broadcast there locally.

萨德·布朗:他们与球队合作是因为这样不仅能够在美国市场登陆,建立产品的分销点,而且在当地球赛播出的时候中国的消费者也能看得到自己的品牌。

In fact the pilgrim theria tells us that at Jerusalem, in the fourth century, all the priests present spoke in turn, if they chose, and the bishop last of all.

事实上,朝圣者theria告诉我们,在耶路撒冷,在第四世纪,所有的神职人员目前以反过来,如果他们的选择,以及最后的主教所有。

In fact the pilgrim theria tells us that at Jerusalem, in the fourth century, all the priests present spoke in turn, if they chose, and the bishop last of all.

事实上朝圣theria告诉我们,在耶路撒冷,在第四世纪,所有的神职人员,目前以反过来,如果他们选择了,和主教最后所有。

The text is start with analysing market economy under completely and fully competing condition, then discover the main performance of market failure under uncompletely and unfully competing condition in the real world, state the reliance relation between market economy and public finance, and its "not marketability "in formal but " public marketability " in fact. Then the thesis excavates the government's " off side " and "omission " phenomenon of the present stage, discuss the way to solve them and the main way to perfect government function.

本文从分析完全和充分竞争状态下的市场经济入手,揭示现实生活中不完全和不充分竞争状态下的市场失灵的主要表现,阐述市场经济对公共财政的依赖关系,以及公共财政形式上的&非市场性&和实质上的&公共市场性&,论述了公共财政调节和补充市场局限的各种作用,挖掘了现阶段政府的&越位&&缺位&现象,探索了克服&越位&&缺位&问题,改变和完善政府职能的主要途径。

Today we've bought into this myth that love is uncontrollable, that it's something that just happens to us; it's not something we control. In fact, even the language we use implies the uncontrollability of love. We say,"I fell in love," as if love is some kind of a ditch. It's like I'm walking along one day and bam! I fell in love. I couldn't help myself.

每个人都有权选择爱或不爱,只是人的爱实在有限,因为内心需要对等的回报,没有回报就不给爱,心里的那杆天平实在无法平衡,好像一生都要走钢丝似的,神从来不强迫人去爱,勉强的爱只会带来关系的远离,丝毫没有益处,因为爱的源头只在神那儿。

"In fact, one way to think about that when on the International Space Station and all the lights on when we look outside,(it's very much like) trying to look at the stars when you're in Boise. You can see some, but go up high in the mountains, up to McCall, and lights out, that's what will be like once undock from the station and we can turn all shuttle lights out, and also for the station folks they can turn their lights out."

&事实上,所想到的只有一种情况,我们在国际空间站,所有的灯都亮着,这时,我们看外面,就像你们在Boise尽量想看清楚天上的星星一样,你会看到一些,但假如你到了山的高处,一直到McCall,你周围没有了灯光,这就像我们离开了空间站,关闭了所有航天飞机的灯,并且对空间站所有成员来说,他们是可以关闭所有的灯的。&

"In fact, one way to think about that when we're on the International Space Station and all the lights are on when we look outside, it's very much like trying to look at the stars when you're in Boise. You can see some, but then if you go up high in the mountains, up to McCall, and you have all the lights out, that's what it will be like once we undock from station and we can turn all our shuttle lights out, and also for the station folks they can turn all their lights out."

事实上,有一种情况是我们可以想到的:在灯火辉煌的国际空间站向外看时可看到一些星星,这与你在博伊西费劲看到的是相类似的,,但是当你在山上一直往上爬,爬至与McCall一样高时,你就会忽略所有的灯光,这与我们一旦驶离空间站时所有梭子灯灭掉的情况是一样的,并且对于空间站的人来说,他们也可以把他们的灯都熄灭。

"In fact, one way to think about that when we're on the International Space Station and all the lights are on when we look outside, it's very much like trying to look at the stars when you're in Boise. You can see some, but then if you go up high in the mountains, up to McCall, and you have all the lights out, that's what it will be like once we undock from station and we can turn all our shuttle lights out, and also for the station folks they can turn all their lights out."

&事实上,当我们在国际空间站上所想的只有一种情况:我们往外面看的时候,所有的灯都亮着,就好像你们在博伊西,想看清楚星星一样,你会看到一些;如果你站在高山上,一直到 McCall ,你周围没有了灯光,这就像我们离开了空间站,关闭所有航天飞机的灯,对空间站的宇航员们来说,他们是可以关闭所有灯的。&

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Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气,收缩臀部肌肉;拱起身体,尽量抬起头来,右腿伸直朝向天花板(膝微屈,以避免肌肉紧张)。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化,但却比去年同期高8%。

However, to get a true quote, you will need to provide detailed personal and financial information.

然而,要让一个真正的引用,你需要提供详细的个人和财务信息。