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Some evidence indicates that the combination of extrinsic, intrinsic and genetic factors all play a role to cause the disc degeneration, with a progressive decrease in proteoglycan content leading to dehydration of the nucleus pulposus, and Type Ⅰ collagen begins to appear in the matrix, the ratio between Type Ⅰ and Type Ⅱ increases. All these cause the swelling pressure, disc height and the disc load bearing ability decrease. The disc progressively herniate and cause radiculopathy and myelopathy.

内因、外因及遗传方面的诸多因素导致椎间盘逐步退变后,其实质就是基质中蛋白多糖的减少,含水量降低,Ⅰ型胶原出现在基质中,Ⅰ、Ⅱ型胶原的比例明显上升,髓核呈纤维样改变,导致椎间盘的膨胀压降低,承重能力下降,椎间高度降低,椎间盘承受的重力不能平均地向各方向传递,致使纤维环疲劳、破裂、髓核突出,造成脊髓或马尾神经受压,引起严重后果。

When human histiocytic lymphoma cell line, U937 cells, was treated with cadmium for 12 hours, evidence of apoptotic features, including change in nuclear morphology, DNA fragmentation, formation of DNA ladder in agarose gel electrophoresis, and phosphatidylserine externalization, were obtained.

人淋巴瘤细胞株(U937)暴露于镉12小时后,细胞呈现典型的凋亡特征,包括细胞核形态学改变、DNA梯形条带的形成、及细胞膜磷脂酰丝氨酸外翻转。

While PcG proteins are best known for the roles in maintaining the correct expression pattern of key developmental regulators, such as Hox genes, there is accumulating evidence that they are also involved in the regulation of cell proliferation and tumorigenesis.

众所周知,PcG蛋白可以维持关键的发育调节因子如Hox基因的准确表达模式。而且,现在越来越多的证据现实,PcG蛋白也参与了对细胞增殖和肿瘤发生的调节过程。

Our overall conclusions are that there is considerable evidence that relative hyperglucagonemia contributes to fasting and postprandial hyperglycemia in patients with T2DM, and there are several new and emerging pharmacotherapies that may improve glycemic control in part by ameliorating the hyperglycemic effects of this relative glucagon excess.

我们的总结论是大量的资料表明相对的高胰高糖素血症可导致T2DM病人的空腹和餐后高血糖,新出现的几种药物疗法可以通过改善相对胰高糖素过剩引起的高血糖从而部分的提高血糖控制能力。

The main findings of the empirical analysis include: 1 The decisions concern the choices of auto ownership, mode to work, and auto use were made simultaneously and interrelatedly. 2 The decline in correlation between the choices of auto ownership and use as the number of vehicle increase indicated that to own multi-vehicles in not necessary due to the demand for auto use. 3 Both price elasticity and income elasticity for auto ownership are low. This evidence implies that auto has become a kind of necessity for household. Therefore, the effect of decreasing the tendency of auto growth by means of increasing the cost of owning auto would not be significant. The price elasticities of auto use are between -0.48 and -0.78. 4 There are same underlying factors influencing auto ownership, mode to work, and auto use including: parking time at residential location, accessibilities to work location by auto and transit, auto use unit cost, and the percentage of auto use for work. These factors indicate a direction for the formatting of future automobile policies.

本研究以台湾地区之家户个体资料从事实证分析,实证分析之主要结论如下:1小汽车持有数量、工作者工作运具选择、与小汽车使用量等选择间确有相关与联立性存在;2小汽车持有数量选择与小汽车使用量选择间之相关性会随小汽车持有数量的增加而降低,显示选择持有多部小汽车并非完全基於小汽车使用之需要;3小汽车持有之价格弹性与所得弹性均偏低,显示小汽车已成为民生必需品,欲以提高小汽车持有成本之价格手段来抑制小汽车持有,并无法竟其功,小汽车使用需求之价格弹性则在-0.48与-0.78间;4影响小汽车持有数量、工作者工作运具、与小汽车使用量等选择主要之相关或共同因素包括:家户附近停车状况、私人运具与大众运输工具之工作可及性、小汽车单位使用成本、与小汽车工作使用比率等,以上这些影响因素可为日后小汽车相关政策的研拟提供一方向。

They say their results support the hypothesis that ERK pathway activation caused by lamin abnormalities is an underlying cause of heart-muscle degeneration in EDMD and that their new results provide evidence that blocking ERK could prevent or delay the onset of heart failure in this disease.

研究者说,他们的研究结果支持了lamin蛋白质的不正常激活了ERK信道是导致Emery-Dreifuss进行性肌营养不良患者心脏肌肉退化的原因的假说。同时他们的最新研究结果,揭示抑制ERK信道能够避免或者延迟Emery-Dreifuss进行性肌营养不良实验鼠心力衰竭的发生。抑制ERK信道的药物已经在癌症患者中使用,证明是安全的。

The present results provided evidence that the descending projections from SRD might directly or indirectly modulate the activities of neurons in the spinal cord and Vc,especially in laminae Ⅰ and Ⅱ.

上述结果提示,SRD发出的下行纤维主要调控脊髓和Vc中的神经活动。

On the other hand, because the insular region is mainly supplied by the M2 segments, only loss of the insular ribbon without obscuration of the lentiform nucleus may be usually seen in type 3 or type 4 occlusions. Although there are few exceptions of type 1 occlusion manifesting a grade I CT sign in the very early period of ischemia, grade I CT signs are usually considered as supporting evidence of absent lenticulostriate artery involvement.

尽管在缺血性卒中发病后的超早期,1型大脑中动脉闭塞(大脑中动脉主干起始段闭塞)患者的深部大脑中动脉分布区可能偶尔也会出现I级早期CT征象(细微低密度区局限于岛叶,基底节区正常);但深部大脑中动脉分布区I级早期CT征象(细微低密度区局限于岛叶,基底节区正常)的出现,通常提示豆纹动脉未受累。

In addition, we had obtained evidence of harboring the lysogenic phages in Stroptococcus suis type 2, but the relationship of this phage with the bacterial virulence and adaptation was uncertain.

尤其是猪链球菌2型,不仅对猪致死性强,而且可引起人的感染和死亡1998—1999年夏季曾在我国江苏省部分地区猪群中暴发流行2型猪链球菌病并导致相关从业人员感染。。。。。。

BACKGROUND: Studies from Asia have suggested that zinc supplementation can reduce morbidity and mortality in children, but evidence from malarious populations in Africa has been inconsistent.

背景:从亚洲的研究中已经提议,锌补充治疗能降低儿童的发病率和死亡率,但是来自于非洲的疟疾人群的证据与此相矛盾。

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Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车,和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特,那个是爱朗。

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