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The paper, which is based on the "Research and Development of the Speed-up Train"s Manipulation of Optimization and Train Simulator project, concerns the sound system in the Train Simulator. In the paper, the sound system includes two parts contents: firstly, improving the sound effect of the sound simulation system in the Train Simulator and enhancing 3D sound effect, such as sense of distance, sense of orientation, Doppler Effect etc, to make the sound of training environment more verisimilar; secondly, realization of the speech communication in network between teacher and student in the Train Simulator.

本文是以铁道部科技发展项目"提速列车优化操纵与机车仿真器研究开发"为依托，对机车仿真器的声音系统进行研究：第一，对机车仿真器中声音仿真系统的音效进行改进，增加3D音效，如声音的距离感、方位感、多普勒效应等，使得训练环境音响更加逼真；第二，实现机车仿真器中教员与学员间的语音网络通讯。

Because of its unique structure, Nano-particle shows its small dimension effect, quantum effect, area effect, macroscopic quantum tunnel effect, it displays special function in optics, electrics, calorifics, magnetics, absorption, reflection, adsorption, Catalyzing and alkaloid etc.

纳米微粒因其独特的结构状态，产生出小尺寸效应、量子尺寸效应、面积效应、宏观量子隧道效应等，从而使纳米材料显现光、电、热、磁、吸收、反射、吸附、催化以及生物活性等特殊功能。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

Multilayered structure of compositionally modulated alloys, in which there are thin film effect, interface effect, coupling effect and periodicity effect present, may give rise to enhanced or novel layer property.

组分调制合金的多层膜结构中由于存在薄膜效应、界面效应、耦合效应和周期性效应而使特性增强或产生出新颖的特性。

Dealcoholization temperature markedly influences the surface area and porosity of the resultant MAO-supports. When the support was pretreated at lower or higher temperature, the corresponding MAO-support shows very low surface area;2.XRD and IR analyses indicate that MAO has reacted with the residual ethanol in the supports, which is an important manner to get MAO fixed on the carrier. Morever, XPS analyse indicates that MAO can also be coordinated with MgCl_2, which is another way to get MAO fixed on the support;3.ICP and EDX analyses indicate that dealcoholization temperature not only determined the element content on the solid catalyst, but also influences the element distribution on the carrier;4.The activities of the supported phenoxy-imine catalysts and the properties of resultant polymers are strongly dependent on the dealcoholization temperature. The support (MSP-5) obtained by treating MgCl_2·2.56C_2H_5OH at 160℃for 4 h, then modified by MAO is very effective for immobilizing complex 3, the resultant solid catalyst (MSPC-5) shows very high activity in ethylene polymerization, and its kinetics of polymerization is stable during the reaction process. Finally, PEs with spherical morphology and high bulk density (over 0.35g/ml) were obtained, without reactor fouling;5.In this work, polymerization conditions such as alkylaluminums, Al/Zr ratio, temperature and H_2 had a pronounced effect on the activity of MSPC-5 and properties of PE;(3). New MgCl_2-Supported Single-Site Catalysts for Ethylene PolymerizationIn this work, a kind of new MgCl_2 support was obtained by anhydrous MgCl_2 co-milled with solid MAO, and it is a creative contribution. Then some single-site catalysts were supported on the new MgCl_2 support, and the resulted solid catalysts were tested in ethylene polymerization, the results indicated that:1.XRD and IR analyses indicate that MAO does be coordinated with MgCl_2, which is in good agreement with the results obtained by XPS;2.co-mlling time had no obvious effect on the texture of support after 12 hours;3.In this work, MgCl_2 was co-milled with solid MAO for different hours, and then complex 3 was supported on these co-milled supports. It was found that co-milling time markedly influences the activity of solid catalysts, but it had negligible effect on the kinetic profile and the properties of resultant PE.

XPS研究结果表明，MAO不仅仅只和乙醇作用，MAO还与MgCl_2本身有一定的作用，这是一个极为重要的发现；3、通过ICP和EDX表征，发现载体的脱醇温度直接影响着元素在固体催化剂中的含量及分布；4、脱醇温度极大地影响着负载苯氧基亚胺类催化剂的活性和聚合物的性能，特别是原始载体经160℃活化4小时制备得到的固体催化剂MSPC-5的活性明显高于其他脱醇温度条件下制得的固体催化，并且催化剂寿命长，表现出稳定的动力学行为，最终获得了高堆密度(大于0.35g／ml)的球形聚乙烯颗粒；5、本文选择MSPC-5为研究对象，考察了聚合反应参数对催化剂的活性及其聚合物的影响，研究发现：不同的烷基铝对催化剂具有非常重要的影响，特别足TIBA对MSPC-5的助催化活性最高，烷基铝的加入量有一个较佳值，聚合温度为80度时活性最高，H_2的加入使催化剂的活性明显降低且聚合物的分子量也减小；、新型氯化镁载体负载单活性中心催化剂催化乙烯聚合本文创造性采用固体MAO与无水氯化镁直接进行共研磨，制备出了一种的新型的氯化镁载体，并将该载体用于多种单活性中心催化剂的负载化研究，研究表明：1、通过BET、XRD的表征，再次证实了MAO与MgCl_2之间具有直接作用，与XPS的研究结果相一致；2、当研磨时间高于12小时时，延长研磨时间对载体的结构没有显著的影响；3、将配合物3负载于共研磨时间不同的一系列载体上，乙烯聚合结果表明，尽管共研磨时间对负载催化剂的活性具有明显的影响，但是它对聚合物的性能以及催化剂的影响不明显。

The main investigation contents include:(1) the effect of slag deoxidizers on reduction velocity of slag and contents of C, Si, Al in steel;(2) the effect of steel deoxidizers on desulphurization;(3) the effect of adding BaO into slag on desulphurization;(4) the effect of magnesium-based desulphurizer on desulphurization ...

主要的研究内容包括：(1)不同炉渣还原剂对炉渣还原速度及对钢液增碳、增硅、增铝的影响；(2)不同脱氧剂对钢液脱硫的影响；(3)顶渣中BaO的配入量对钢液脱硫的影响；(4)镁基脱硫剂钢液脱硫效果及对钢中夹杂物的影响。

Asymmetric over-introgression of the indica alleles on chromosome 7 and many specific regions on other chromosomes in the japonica genetic background is consistent with the general trend observed in the RIL and F_2 populations of the same cross, suggesting a high genetic load in the japonica gene pool, and japonica genome experienced a very severe bottleneck by artificial domestication.2 Genetic background effect on QTL expression of grain weight and its related traitsGenetic background effect on main-effect QTL and digenic epistatic QTL mapping for GWT and its related traits including GL, GW and GT was dissected by a large set of reciprocal introgression lines and recombinant inbred lines derived from Lemont and Teqing in Beijing environment.

籼粳相互导入具有不对称性，粳稻向籼稻背景的平均导入频率与期望值相仿，相反籼稻向粳稻背景的平均导入频率大大高于理论预期，位于第7染色体和一些其它染色体的特殊区段存在籼稻等位基因的超导入现象，在来自相同亲本的重组自交系和F_2群体中也观察到同样的导入趋势，表明粳稻基因组具有较大的遗传负荷，粳稻品种在人工驯化过程中曾经历过一个非常剧烈的遗传瓶颈。2水稻籽粒相关性状的主效和互作QTL表达的遗传背景效应利用Lemont和特青培育的双向导入系和重组自交系群体，在北京环境下定位影响千粒重及其相关性状如粒长、粒宽和粒厚的主效和互作QTL，分别在特青背景导入系、Lemont背景导入系和重组自交系下检测到影响千粒重及其相关性状的主效QTL分别为33个、27个和13个，互作QTL分别为4个、8个和23个，其中仅有6个主效QTL(QGwt5，QGl1，QGl3b，QGl4，QGw7和QGw8)在籼粳两个不同背景下共同表达，3个主效QTL(QGwt5，QGwt7a和QGt5)在导入系和重组自交系中共同表达，分别占检测到影响这些性状QTL总数的11.1%和4.3%，未检测到在3个背景下相同表达的互作QTL。

Pickup modeling transforms the sound of a single-coil pickup into that of a humbucking pickup, a guitar synth that lets you play synth sounds, an intelligent pitch shifter that automatically harmonizes with your playing, a talk effect that produces the impression that your guitar is speaking, a slow attack effect that creates violin-type swells, a feedback effect that allows feedback playing techniques that are normally possible only at high volumes, a rotary speaker that changes speed in response to your picking or fingering dynamics, a fretless bass effect that simulates the distinctive sound of a fretless bass, and many more are ready for your use.

皮卡造型变换声单线圈皮卡，变成了humbucking皮卡，一把吉他的合成，让你玩合成音效，智能型沥青移自动理顺与你玩，讲座的效果，从而产生一种印象，你的吉他是说，一个缓慢的攻击效果，创造小提琴型涌浪，反馈作用，使反馈的演奏技巧，通常只有在高卷，旋转扬声器，变化速度回复您或采摘指法动态fretless一个低音效果，模拟不同声音一fretless男低音而更多的人准备好供您使用。

By the numerical analysis of the ultimate bearing capacity of two- and three-dimensional footing under combined loading mode, the results show that the effect of alteration of underground water lever on bearing capacity of three-dimensional foundation is more than on that of two-dimensional foundation, the effect of soil gravity on bearing capacity of three-dimensional foundation is more than that of two-dimensional foundation. At the same time, the numerical calculation process of ABAQUS indicates that whether the geostatic stress is balanced or not has great effect on the numerical convergence. In view of the effect extent of dilation angle of soil on the ultimate bearing capacity and the failure pattern of foundation, the condition of two-dimensional plane strain is higher than that of the three-dimensional foundation.

复合加载模式下，通过对三维矩形基础和二维条形基础进行数值分析，结果表明：黏性土地基中地下水位的变化，对三维矩形基础极限承载力的影响程度高于对二维条形基础的影响；在求解地基极限承载力的过程中，土体重度对三维矩形基础的影响明显高于对二维条形基础的影响，同时ABAQUS数值计算过程表明，地基土体地应力能否合理平衡，对数值求解过程中是否收敛有很大的影响；就土体剪胀角对地基极限承载力的影响程度而言，二维平面应变情况下土体剪胀角对极限承载力的影响比三维情况下的影响更明显，即土体剪胀角对条形基础极限承载力的影响高于三维矩形基础。

The experiment on electromagnetism pulse biology effect could suggest that quantities-effect of EMP effect on system morphemic and function with applying different frequency, power and expose time. Combined with epidemic investigation and medical psychological research in EMP researcher, the immediate, early stage and middle and long-term biological effect of EMP was elucidated and EMP protection standard was established.

电磁脉冲(electromagnetism pulse，EMP)生物学效应实验是通过应用不同频率、功率、暴露时间的EMP照射动物，明确EMP所致各系统形态和功能危害的量效关系，探索其效应机理；并结合对EMP从业人员的流行病学调查和医学心理学研究，揭示EMP所引起的即刻、早期、中期和远期生物学效应，提出EMP卫生防护标准，为物理防护和医学防护的研究提供重要的理论依据和实验依据。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！