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Both Russia and Japan coveted control of Korea and Manchuria. In February 1904, the Japanese launched a surprise attack against the British garrison in Port Arthur, laying siege to the town. In May 1905, the Russian fleet, which had come to Port Arthur's aid, was destroyed in the naval battle at Tsushima, confirming the Japanese victory. The Russian capitulation, signed in September 1905, gave Japan control of Korea.

俄国和日本同时觊觎对朝鲜和满洲的控制权。1904年2月，日本对在旅顺口的英国驻军发动了突然袭击并包围了旅顺口。1905年5月，前来旅顺口援助的俄国舰队在对马海战中被摧毁从而确认了日本的胜利。1905年9月，日俄两国签订了休战书，日本取得了对朝鲜的控制权。

Results (1)Relevance rate of behavioral problems in type 1 diabetes group was 20.2%,two fold significantly higher than that in the control group(8.2%)(P=0.000).(2)Logistic analysis showed that risk factors concerned behavioral problems in diabetic children and adolescents included patients lived in rural areas,poor parents' marital relationship,poor parent- child relation,improper cultural ways,poor communication and understandings between family members,uniparental family and poor control of blood glucose.(3)It was found that diabetes was the most significant risk factor affected the occurrence of behavioral problems among all related factors based on the analytic results in both the type 1 diabetes group and the health group.Conclusions (1)Children and adolescents with type 1 diabetes are the high- risk population who are apt to the occurrence of behavioral problems.

结果①行为问题的检出率：糖尿病患儿检出率为20.0%，与健康对照组(8.2%)比较，糖尿病患儿行为问题检出率高于健康对照组P=0.000；②Logistic回归分析显示，与糖尿病患儿行为问题有关的危险因素分别为在农村生活、双亲关系紧张、亲子关系差、缺乏直接感情交流、教育方式不当、对子女了解较少、仅由父母中的一方承担管理子女的责任及血糖控制不良；③将健康对照组与1型糖尿病组综合分析后发现：影响行为问题发生的所有危险因素中，患糖尿病的相对危险度最大。

Methods Thirty-two New Zeeland rabbits were randomly assigned into two groups as experiment group (n=24) end control group (n=8). Each rabbit in experiment group was given injection with 8.0 mg/kg of hydrocortisone acetate for two times per week, while rabbits in control group were given normal saline in same quantity. Serum glucocorticoid concentration, total cholesterol and triglyceride were determined respectively before and 2, 4, 6 and 8 weeks after treatment. Rabbits were sacrificed at the 2nd, 4th, 6th and 8th week. The rabbits, sacrificed at the same time point, were stratified into group A and group B according to the GC concentration, in an attempt to observe the rate of empty bone lacuna and glucocorticoid receptor expression in the soft tissue around hips.

32只新西兰大白兔随机分成两组：实验组(n=24)每周2次肌注醋酸氢化可的松注射液8.0mg/kg造模，对照组(n=8)每周2次肌注等量生理盐水各组于处理的0、2、4、6、8周抽血测定空腹血清GC血药浓度及而清总胆固醇、甘油三脂水平，并于第2、4、6、8周分批处死动物，将同批处死的实验组动物依据血清GC浓度分为A、B两组，观察股骨头的空骨陷窝率及髋周软组织中糖皮质激素受体的表达。

In hypothalamic median eminance of kidney Yang deficiency group, the bounds of ependymocytes were dim, distribution of their microvillus changed, the top of microvillus enlarged and became spherical, and holes occurred on the surface of the cells. In that of control group, the cell arranged in order and the cell bouns were clear, the microvillus were equal in thickness and in long, thin acerose thread wool shape. The surface ultrastructure of ependymocytes on hypothalamic median eminance in herb group was similar to that of control group.

肾阳虚大鼠垂体内分泌细胞和甲状腺细胞存在着不同程度的粗面内质网、高尔基体扩张，线粒体空化，细胞变形，核固缩等超微结构的损伤；中药组大鼠垂体超微结构与正常组类似，细胞形态完整，结构清晰，细胞器结构正常，含有各种大小不等、形态不一的分泌颗粒，但甲状腺细胞超微结构与肾阳虚组相比未见明显改善。

Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.

其作用机制之一是由于该药具有良好的调脂降脂作用，其不仅能明显降低血清LDL-c及升高HDL-c含量，且能有效阻止TC沉积于血管壁，从而保护内皮细胞结构完整；此外，温心胶囊尚具有明显的抗氧化作用，该药不仅能明显降低血浆LPO含量，且能提高SOD活性，同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓，提高HO活性，通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放，从而抑制血小板聚集，抗血栓形成。4 温心胶囊能明显提高t-PA活性，降低PAI-1活性，增强纤溶功能，从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成，其抑制作用不是直接杀伤抑制，而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂，图象分析结果证实，该药治疗组脂斑面积比对照组缩小了54％和58％，光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。

Methods 12 guinea pigs of 20 months with 3 cm×3 cm hair sheared from their backs were divided into control group and experimental group. Rhodosin and deer serum preparation was besmeared on the skin of guinea pigs in experimental group, and cosmetic matrix was besmeared on the skin of animals in control group for 60 d. The distribution of type Ⅲ collagen was observed with Sirius red staining and HE staining. The fission index of the cells of stratum basale, the thickness proportion of stratum corneum to epidermis, the volume density of the collagen fibers and small blood vessel in dermis, the number of fibroblasts in aging skin were meassured with technique of sterology.

背部被剪去3 cm×3 cm毛的12只20月龄豚鼠被随机均分为给药组和对照组，给药组涂抹红鹿制剂，对照组涂抹化妆品基质，连续涂抹60 d；应用天狼猩红、HE染色和体视学技术分别观察和测定老化皮肤中Ⅲ型胶原的分布、表皮基底层细胞的分裂指数、角质层同表皮厚度的比例、真皮胶原纤维和微血管的体密度和成纤维细胞的数目。

Results: IL-8 protein was located in the epithelium of viii. The expression of IL-8 was significantly increased in RSA group than that in the control group. Positive IL-8 cells was shown in decidua of RSA group, and its IL-8 level was higher than that in the control group. By hematoxylin-eosin staining. trophoblastic layer was found to get thinner, cells of trophoblastic layer denatured or necrotized, and turned acidophily, and the fibration of villous axis increased in RSA; decidual cells lost connection, a part of decidual cells appeared cytoclasis and turned more acidophilic, and nuclei disappeared in RSA.

结果：在绒毛组织中，IL-8蛋白定位于绒毛上皮细胞的细胞质内，且病例组的表达明显高于对照组；在蜕膜组织中；病例组蜕膜细胞的胞质内可见IL-8蛋白表达，且高于对照组；H-E染色可见病例组绒毛组织的滋养层变薄，细胞变性甚至坏死、嗜酸性增强，绒毛中轴纤维化程度增强；蜕膜组织中蜕膜细胞失去细胞间连接，部分蜕膜细胞解体、核消失。

And there were no evidence changes in histopathologic analysis of brain tissues in other ETU-injected and in control rat embryos. 2. Results of In situ cell apoptosis detection In E20 cerebral cortex, more Tunel cells were found in encephalocoele group than control group,and the results were significant.

二、应用细胞凋亡原位检测法检测不同组E20胎鼠大脑皮质中细胞凋亡情况 E20胎鼠大脑皮质中Tunel阳性细胞数目在正常组、给药无畸形组及脊柱裂组细胞凋亡数无明显改变，而在脑膨出组胎鼠大脑皮质细胞凋亡数明显多于对照组，计算凋亡细胞百分率，然后用X~2检验进行分析，脑膨出组和对照组的细胞凋亡指数差异有统计学意义(P.05)。

Expression of Caspase-3 and bcl-2 protein In E20 cerebral cortex, the expression of cleaved Caspase-3 in the encephalocoele group are higher than that in control group, and the expression of bcl-2 in the encephalocoele group are lower than that in control group. These findings were consistent with the results of the western blot analysis in E14 Brain.

四、Western-blot检测E14、E20胎鼠大脑皮质中caspase-3、bcl-2蛋白的表达 1、用Western-blot方法检测不同组E20胎鼠大脑皮质中caspase-3、bcl-2蛋白表达水平，结果表明对照组、给药无畸形组、脊柱裂组胎鼠大脑皮质中caspase-3、bcl-2蛋白表达水平无明显改变，而脑膨出组胎鼠大脑皮质中caspase-3蛋白活化片段表达水平明显增加，bcl-2蛋白表达水平明显减少。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。