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Therefore, with the approval of the sacred Lateran council, by apostolic authority and fullness of power, we approve and renew, and order to be observed and maintained in their totality and without change, the said letter together with each and every statute, ordinance, decree, explanation, agreement, compact, promise, wish, penalty, restraint and clause contained in it; especially the clause by which it was our will that if the said king of France does not approve and ratify the aforesaid letter, and each and every thing contained in it, within six months from the date of this present letter, and does not arrange for the contents to be read, published, sworn to and registered, like all other royal constitutions in his kingdom and in all other places and lordships of the said kingdom, for all future time without limit, by all the prelates and other ecclesiastical persons and courts of parlements, and if he does not convey to us, within the said six months, letters patent or authentic written documents concerning each and all of the aforesaid matters about the acceptance, reading, publication, oath and registration referred to, or does not deliver them to our nuncio attached to the king, in order to be passed on by him to us, and does not subsequently arrange for the letter to be read each year and effectively observed without alteration exactly as other binding constitutions and ordinances of the king of France have to be observed, then the letter itself and whatever follows from it are null and void and of no force or value .

因此，在徵得安理会的神圣拉特兰，由使徒的权威和充实力量，我们赞成和更新，并以得到遵守和维护他们的整体，没有变化，该信连同每一个章程，条例，法令解释，协议，契约，承诺，希望，罚款，限制和条款，载於它；特别是其中的条款，这是我们的意志，如果说法国国王不同意和批准上述信件，和每一个事载於它，在6个月内之日起的本信，并没有安排的内容来阅读，出版，发誓要和登记，象所有其他王国的宪法，他在英国和其他所有的地方和lordships英国的说，今后所有的时间没有限制，所有的主教和其他教会人员和法院parlements ，如果他不转达给我们，在上述6个月，英皇制诰或真实的书面文件和所有的每一个上述事项的接受，阅读，出版，宣誓和注册提到，或者没有交给我们的大使重视国王，以便通过他给我们，并没有随后安排信每年读和有效地观察到完全没有改变的其他具有约束力的宪法和法令的法国国王都必须遵守，那麼，这封信本身，无论从它是无效的，没有武力或价值。

In order to remove completely all excuse and leave no pretext of any impediment to anyone who is obliged to attend, in addition to the public guarantee which was clearly granted at the summoning of this council to all coming to it we give, concede and grant, acting on the advice and power mentioned above with the same council's approval, to each and all who have been accustomed to be present at the meetings of general councils and are coming to the present Lateran council, as well as to members of their personal staff, of whatever status rank, order and condition or nobility they may be, ecclesiastical and secular, a free, safe and secure safe-conduct and, by apostolic authority in the meaning of the present letter, full protection in all its aspects, for themselves and for all their possessions of any kind as they pass through cities, territories and places, by sea and land, which are subject to the said Roman church, for the journey to the Lateran council in Rome, for remaining in the city of freedom, for exchanging views according to their opinions, for departing therefrom as often as they may wish and also after four months from the conclusion and dispersal of the said council; and we promise to give readily other safe-conducts and guarantees to those desiring to have them.

因此，为了消除所有藉口，完全没有留下任何藉口，任何障碍，任何人谁有义务出席，除了向公众保证这显然是理所当然的传唤本局所有来，我们给予承认和赠款，代理的意见和权力与上述相同的安理会的批准，每个和所有谁已经习惯於将出席会议的理事会和大会即将於本拉特兰理事会，以及各成员的个人的工作人员，什麼样的地位等级，秩序和条件或贵族，他们可能会，教会和世俗的，一个自由，安全和可靠的安全行为，并通过使徒权威的含义本信，充分保护的各个方面，为自己和对所有的财产的任何形式，因为它们穿过城市，地区和场所，由海上和陆地，这是受说罗马教会，为旅拉特兰理事会在罗马，为留在城市的自由，为交换意见，根据他们的意见，由此出发，他们经常不妨也从4个月后的结论和分散的说，安理会和我们承诺放弃容易其他安全进行，并保证对那些希望他们。

I will compress them within the narrowest compass they will bear, staling the general principle, but not all its limitations. Equal and exact justice to all men, of whatever state or persuasion, religious or political; peace, commerce, and honest friendship with all nations, entangling alliances with none; the support of the State governments in all their rights, as the most competent administrations for our domestic concerns and the surest bulwarks against antirepublican tendencies; the preservation of the General Government in its whole constitutional vigor, as the sheet anchor of our peace at home and safety abroad; a jealous care of the right of election by the people--a mild and safe corrective of abuses which are lopped by the sword of revolution where peaceable remedies are unprovided; absolute acquiescence in the decisions of the majority, the vital principle of republics, from which is no appeal but to force, the vital principle and immediate parent of despotism; a well-disciplined militia, our best reliance in peace and for the first moments of war, till regulars may relieve them; the supremacy of the civil over the military authority; economy in the public expense, that labor may be lightly burthened; the honest payment of our debts and sacred preservation of the public faith; encouragement of agriculture, and of commerce as its handmaid; the diffusion of information and arraignment of all abuses at the bar of the public reason; freedom of religion; freedom of the press, and freedom of person under the protection of the habeas corpus, and trial by juries impartially selected.

我打算尽量简略地加以陈述，只讲一般原则，而不讲其全部范畴：不管人们的地位、宗教信仰或政治主张有何不同，人人都应得到平等和绝对公正的待遇；与所有国家和平相处，互相通商，并保持诚挚的友谊，但不与任何国家结盟，以免纠缠不清；维护各州政府的一切权利，使它们成为处理我们内政最合适的机构，以及抵制反共和趋势的最有力的屏障；维护全国的政府，使之能充分行使宪法赋予的权力，从而成为对内和平和对外安全的最后堡垒；要十分注意维护人民的选举权，因为革命留下的弊端，一时没有和平的补救办法，而人民选举权乃是对那些弊端的一种温和而安全的矫正手段；要绝对服从多数的决定，这是共和政体的主要原则，离开这个原则，便只好诉诸武力，而这就是专制的主要原则和直接起源；要维持一支纪律严明的民团，以作为和平时期和战争初期的最好依仗，直至正规军来接替；实行文权高於军校的政制；节省政府开支，减轻劳动人民的负担；如实偿还我们的债务，把维护政府的信用看作神圣的义务；促进农业发展，并鼓励以商辅农；传播知识并以公众理智为依据谴责一切弊端；保障宗教自由及出版自由，并以人身保护令以及由公平选出的陪审团进行审判来保障人身自由。

I will compress them within the narrowest compass they will bear, staling the general principle, but not all its limitations. Equal and exact justice to all men, of whatever state or persuasion, religious or political; peace, commerce, and honest friendship with all nations, entangling alliances with none; the support of the State governments in all their rights, as the most competent administrations for our domestic concerns and the surest bulwarks against antirepublican tendencies; the preservation of the General Government in its whole constitutional vigor, as the sheet anchor of our peace at home and safety abroad; a jealous care of the right of election by the people--a mild and safe corrective of abuses which are lopped by the sword of revolution where peaceable remedies are unprovided; absolute acquiescence in the decisions of the majority, the vital principle of republics, from which is no appeal but to force, the vital principle and immediate parent of despotism; a well-disciplined militia, our best reliance in peace and for the first moments of war, till regulars may relieve them; the supremacy of the civil over the military authority; economy in the public expense, that labor may be lightly burthened; the honest payment of our debts and sacred preservation of the public faith; encouragement of agriculture, and of commerce as its handmaid; the diffusion of information and arraignment of all abuses at the bar of the public reason; freedom of religion; freedom of the press, and freedom of person under the protection of the habeas corpus, and trial by juries impartially selected.

我打算尽量简略地加以陈述，只讲一般原则，而不讲其全部范畴：不管人们的地位、宗教信仰或政治主张有何不同，人人都应得到平等和绝对公正的待遇；与所有国家和平相处，互相通商，并保持诚挚的友谊，但不与任何国家结盟，以免纠缠不清；维护各州政府的一切权利，使它们成爲处理我们内政最合适的机构，以及抵制反共和趋势的最有力的屏障；维护全国的政府，使之能充分行使宪法赋予的权力，从而成爲对内和平和对外安全的最后堡垒；要十分注意维护人民的选举权，因爲革命留下的弊端，一时没有和平的补救办法，而人民选举权乃是对那些弊端的一种温和而安全的矫正手段；要绝对服从多数的决定，这是共和政体的主要原则，离开这个原则，便只好诉诸武力，而这就是专制的主要原则和直接起源；要维持一支纪律严明的民团，以作爲和平时期和战争初期的最好依仗，直至正规军来接替；实行文权高于军校的政制；节省政府开支，减轻劳动人民的负担；如实偿还我们的债务，把维护政府的信用看作神圣的义务；促进农业发展，并鼓励以商辅农；传播知识并以公衆理智爲依据谴责一切弊端；保障宗教自由及出版自由，并以人身保护令以及由公平选出的陪审团进行审判来保障人身自由。

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Results Leucocytopenia and lymphocytopenia were seen in all the patients. Two patients had slightly decreased peripheral blood T lymphocyte count. Alanine aminotransferase and aspartate transaminase levels increased slightly in 3 patients. No hypoxemia was seen in all the patients. Both SARSIgM and IgG seroconversion occurred earlier in all the patients with the titer increased more than 4fold shortly. Neutralization test was positive in all the patients. SARS coronary virus RNA was detected by polymerase chain reaction in pharyageal swabs only in 1 patient.

结果 确诊的SARS患者白细胞及淋巴细胞呈不同程度降低，下降时间较流行时提前，下降程度较小；2例外周血T细胞亚群计数轻微降低；3例丙氨酸转氨酶和天冬氨酸转氨酶轻度升高；肾功能、血糖、血脂及心肌酶均无异常；所有患者血清SARSIgM/IgG抗体早在发病第6 d由阴转阳，滴度在短期内呈4倍以上升高，中和抗体实验阳性，1例咽拭子中检测出SARS冠状病毒RNA。

It is binding over all the globe, in all countries, and at all times; no human laws are of any validity if contrary to this, and such of them as are valid, derive all their force, and all their validity, and all their authority, mediately and immediately, from this origin; Therefore, Resolved, That such laws as conflict, in any way, with the true and substantial happiness of woman, are contrary to the great precept of nature, and of no validity; for this is "superior in obligation to any other."

因此，决议认爲，凡是与妇女真正和实质的幸福冲突的法律，不论其形式如何，都是与自然的伟大法则相矛盾的，都是无效的，因爲&自然的伟大法则比任何其它法则都具有更高的约束性&。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

As all that of all ... one and all over all 说来 set all sweep all before one every thing before one sweet damn all takingall in all

总计； 总的说来十有八九，多半，可能性很大十有八九，多半，可能性很大一切都完了；毫无希望了。

After refreshing my self, I got all my Cargo on Shore, and began to examine the Particulars: The Cask of Liquor I found to be a kind of Rum, but not such as we had at the Brasils; and in a Word, not at all good; but when I came to open the Chests, I found several Things, of great use to me: For Example, I found in one, a fine Case of Bottles, of an extraordinary kind, and fill'd with Cordial Waters, fine, and very good; the Bottles held about three Pints each, and were tipp'd with Silver: I found two Pots of very good Succades, or Sweetmeats, so fastned also on top, that the Salt Water had not hurt them; and two more of the same, which the Water had spoil'd: I found some very good Shirts, which were very welcome to me; and about a dozen and half of Linnen white Handkerchiefs, and colour'd Neckcloths; the former were also very welcome, being exceeding refreshing to wipe my Face in a hot Day; besides this, when I came to the Till in the Chest, I found there three great Bags of Pieces of Eight, which held about eleven hundred Pieces in all; and in one of them, wrapt up in a Paper, six Doubloons of Gold, and some small Bars or Wedges of Gold; I suppose they might all weigh near a Pound.

我先吃了点东西，把所有的东西都搬到岸上，并仔仔细细地查看了一番。我搬回来的那桶酒是一种甘蔗酒，但与我们巴西的甘蔗酒不一样。一句话，这种酒非常难喝。可是，我打开那两只大箱子后，找到了几样东西对我非常有用。例如，在一只箱子里，有一只精致的小酒箱，里面的酒瓶也十分别致，装的是上等的提神烈性甜酒，每瓶约三品脱，瓶口上还包着银子；还有两罐上好的蜜饯，因为封口很好，咸水没有进去。另外还有两罐却已被海水泡坏了。我又找到一些很好的衬衫，这正是我求之不得的东西。还有一打半白麻纱手帕和有色的领巾。麻纱手帕我也十分需要，大热天拿来擦脸真是再爽快也没有了。此外，在箱子的钱箱里，有三大袋西班牙银币，约一千一百多枚，其中一袋里有六块西班牙金币和一些小块的金条，都包在纸里，估计约有一磅重。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。