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In spite of the low binding affinity between the Mis13/Mis14 dimer and the Mis12/PMF1 dimer,the four proteins form a heterotetramer with a stoichiometry of 1:1:1:1 when these four proteins expressed synchronously,implying that the four subunits can act synergically to form an intact Mis12 complex in vivo.

Mis12复合物在动点上的功能已经较为清楚，但是它们分子间结合方式仍是未知的，为了解析Mis12复合物的分子构架，我们引入了共表达系统在体外表达和重组该复合物。

Subtilis IA752S was still thermostable, with optimal reaction temperature 90℃, implying that the thermostability was determined by its own amino acids sequences.

subtilis 1A752S中分泌表达的α-淀粉酶仍具有耐高温的特性，酶反应的最适温度为90℃，表明酶的热稳定性由蛋白质本身的氨基酸序列决定的。

By transcriptomic analysis, we found that there were 128 genes had both the sense and anti-sense transcripts our previous CB EST data. Unexpectedly, fifteen proteins with the corresponding antisense RNAs were identified in the proteomic study, implying that these sense RNAs could be translationally expressed, without being completely interrupted by the antisense RNAs.

在转录组中有128个基因的反义转录本以及相应的正义转录本序列，我们意外地发现，具有反义转录本的15个蛋白质出现在蛋白质组数据中，这个有趣的现象说明在反义转录本存在的条件下，正义转录本可以转录表达，而没有完全被反义转录本阻断。

The eldest wore the white tie, high waistcoat, and thin-brimmed hat of the regulation curate; the second was the normal undergraduate; the appearance of the third and youngest would hardly have been sufficient to characterize him; there was an uncribbed, uncabined aspect in his eyes and attire, implying that he had hardly as yet found the entrance to his professional groove.

因为队伍里没有男子，所以开始时姑娘们相互对舞着，但是随着收工时间的临近，村子里的男性居民就同其他没事的闲人和过路行人一起聚集到舞场的周围，似乎想争取到一个舞伴。

In this thesis, we find that dlg is indispensible in the establishment of anterior-posterior and dorsal-ventral polarity of drosophila oocyte. Removal of Dlg function from the posterior follicle cells using the FLP/FRT system leads to disruption of oocyte skeleton reconstruction that is elicited by the failure of those posterior cells to differentiate normally in mid-oogenesis. We demonstrate that abnormity of Notch, JAK-STAT and EGFR signal pathway in dlg mutants contributes to this aberrant differentiation. dlg null mutant also blocks the normal differentiation of two groups of anterior follicle cell-stretched cell and centripetal cell, but not border cell, with a lower penetrance. However unlike the result in posterior follicle cells, Notch and JAK-STAT signaling are both undisrupted in all mutant anterior follicle cells, implying other fate determinants may be involved.

我们的研究发现，后端滤泡细胞中的Dlg在果蝇卵子发生中期卵母细胞前后轴和背腹轴建立过程中也是必须的，PFC中dlg完全缺失型突变引起PFC的分化异常，导致卵子发生中期卵母细胞骨架重组异常，Stau、Grk等极性决定蛋白定位错误。dlg突变阻碍了Notch、JAK-STAT、EGFR等调节PFC分化的信号通路的激活。dlg突变的PFC也没有获得前端滤泡细胞命运。dlg突变不影响前端滤泡细胞群中边界细胞的分化，但是在一定程度上影响伸展细胞和向心细胞的分化，并且这种影响不依赖于前端滤泡细胞Notch或JAK-STAT信号激活的异常。

BDNF and slit-2 were mainly expressed in the ventricolumna,implying they might be correlated with the limb movement function restore.

且BDNF？ slit-2主要表达于脊髓前角，提示与脊髓损伤后肢体运动功能恢复密切相关？

Wage-bargaining power will also weaken, implying another "jobless" and "wageless" recovery.

工人的工资讨价还价能力将受到削弱，意味着又一次的&没有就业增长&和&没有工资增长&的经济复苏。

Executives say, however, that the group has budgeted for, and is seeing, significant growth in top line revenues and earnings before interest, depreciation, tax and amortisation in the first quarter of 2004 - implying that the business is growing.

不过，管理人员们透露，该集团正如预算中所预计的，在2004年第一季度实现主要业务收入和扣除利息、折旧、税项和摊销前盈利（EBITDA的显著增长，这意味着业务正在发展。

Oronte suggests that he and Alceste shake hands to confirm their affection for one another, implying an aristocratic notion that pacts and rules supercede feelings and emotion.

Oronte表明，他和阿尔切斯特握手，以确认他们的感情一个，这意味着一个贵族的概念，即条约和规则取代的感情和情绪。

This paper provides an in-depth discussion of Morrison's first novel, The Bluest Eye, which applied Derrida's deconstruction, particularly the janus-faced and double-sided idea of différence, implying difference and postponement.

本文试以解构主义大师达西达之重要概念difference，该词意含&区分&及&延迟&双重意义，深入探讨及分析默理逊小说《湛蓝的眼睛》所呈现之二元对立。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。