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This study not only implicated a possible accession for the management of diseases characerised by pathological cell proliferation using drugs targeting PI3K/PTEN/PKB signal system, but also afforded theory evidence for the ideal results of the two agents in the prevention and treatment of atherosclerosis and restenosis after interventive myocardial reperfusion.

此项研究不仅为研制PI3K/PTEN/PKB调节药物用于以细胞过度增生为主要病理改变的疾病治疗展示了可能途径，更为该两种药物在冠心病一、二级预防或冠脉介入治疗后再狭窄防治中取得的理想疗效提供了理论支持。

In the adult, cholinergic neurons in the laterodorsal and pedunculopontine tegmental have been implicated in the generation and maintenance of REMS.

虽然在成年人和动物，胆碱能神经元被认为是主要的REM睡眠的调节神经元，已有实验证实脑桥网状结构及脚桥被盖核胆碱能神经元在REMS的触发和维持中起着关键作用，然而，胆碱能神经元对于幼年期REM睡眠的作用仍有待进一步的研究。

IR、Lipide metabolism disturbance and cytokine have been implicated in the chronic vascular complications of type 2 diabetes mellitus .

IR、脂代谢紊乱、细胞因子共同参与了2型糖尿病慢性血管并发症的发生、发展。

The results of this research implicated that betaine hydrochloride could improve fish meat quality, it participate body lipid metabolism by increasing methylic products of fish liver and muscle.

实验结果提示：甜菜碱可改善肉质，它参与机体代谢活动，使肝脏和肌肉中甲基化产物含量增加，影响肠系膜脂肪酶活力，改变体脂和鱼肉脂肪酸组成，进行体脂重分配。

They have been shown to control cell growth, differentiation and apoptosis; consequently, impaired miRNAs expression has been implicated in tumorigenesis. Recently evidence indicates that patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in tumorigenesis.

很多研究报告指出特定的miRNAs在特定的肿瘤细胞中扮演重要角色，例如：miR-221与miR-222会负向调控p27Kip1而促进PC3前列腺癌细胞增生，因此，如果将miR-221与miR-222的表现抑制掉或是降低，就可以造成PC3细胞的增生减缓。

The disturbances of catecholaminergic neurotransmission have been implicated in the neuropsychiatric and cardiovascular diseases.

在患神经精神病和心血管疾病的患者中发现儿茶酚胺能传递失调，暗示ZNF191基因可能是这些疾病的发生或发展的相关基因。

Mizumura K,Kumazawa T. Modification of nociceptor responses by inflammatory mediators and second messengers implicated in their actiona study in canine testicular polymodal receptors.

痛过敏的产生有赖于许多炎症介质的参与，如PGs，缓激肽，5-羟色胺和白介素B4等，这些炎症介质有的可敏化伤害性感受器，使它们的阈值降低，有的可激活伤害性感受器，有的具有敏化和激活双重作用[4~6]。

Furthermore, the rupture of soft noncalcified plaque has been implicated as the cause of heart attack.

& &此外，破裂的软noncalcified牌匾已被牵连，作为事业的心脏病发作。

Anterior femoral notching during arthroplasty has been implicated as a contributing risk factor for femoral fracture.

关节置换时股骨假体前开槽就包含了股骨骨折的危险因素。

Ystroglycan interaction with laminin should be implicated in the concentration of pericellular laminin and in the constitution of a perisinusoidal basement membrane during lier fibrosis.

stroglycan与层粘连蛋白的相互关系应该与肝纤维化过程中细胞周围层粘连蛋白浓度以及窦状隙周围基底膜的组成有关。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。