查询词典 impairs

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Some people may be addicted to net surfing which impairs their physical and mental health.

有些人沉迷于网上冲浪，这对他们的身心健康有害。

Some people may be addicted to netsurfing, which impairs their physical and mental health.

有些人沉迷于网上冲浪，这对他们的身心健康有害。

Some people may be addicted to netsurfing, which impairs their physical and mental health .

有些人可能沉溺于网上冲浪，这会危害他们的身心健康。

Some people may be addicted to netsurfing, which impairs their physical and me

有些人沉迷于网上冲浪，这对他们的身心健康有害。

What it might mean: Yellow nails with blue beds can point to diabetes, which impairs blood flow to fingers.

它可能意味着：泛黄的指甲可能代表糖尿病，这种病减少了流向手指的血液。

Decision rule chain and distance function of decision rule are proposed, by which the order of decision rules are explained. The group scale's effect on decision quality and the marginal contribution of decision-makers are analyzed. It's pointed out that the increase of the scale will enhance the decision quality with the optimal decision rule applied. Otherwise it is likely to weaken the decision quality. It's proved that for homogeneous group with simple majority rule applied the marginal contribution of decision-maker will decrease while the scale increases or the decisional competencies of other decision-makers increase; 3.We study the group decision-making with a leader in it. It's proved that the existence of the leader impairs the decision quality when the group applies the optimal decision rule.

研究了决策者的决策能力不确定情况下的群体决策，给出了最优决策规则，指出其仍然是广义加权多数规则；提出了决策规则链和决策规则距离函数的概念，利用这些概念解释了群体决策规则的序现象；分析了群体规模对决策质量的影响、决策者决策能力的边际贡献，指出当群体应用最优规则时，群体规模的增大会提高决策质量，否则群体规模的增大可能会削弱决策质量；证明了对于应用简单多数规则的同质群体，随着其规模的增大，决策者决策能力对决策质量的边际贡献会减小；随着其他决策者决策能力的提高，决策者决策能力对决策质量的边际贡献也会减小； 3。

The damage induced by obstruction jaundice could result in liver and kidney function impairs, cruor dysfunction, gastric mucosal injury, immune suppression and liver regeneration suppression.

因此，为了能够安全的行联合肝脏大部切除的肝门部胆管癌根治术，术前必须采取各项措施以提高患者对手术的耐受性。

Out of intention or culpability, the conduct of destroying the securities market order impairs others interests.

证券欺诈行为主体基于主观上的故意或过失对正常的市场交易秩序的破坏行为，造成权利主体的财产利益的损害。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。