查询词典 immune

The same result can also be achieved when optimizing F8 function (Rastrigin's function). Comparing to EGA, KEGA is easy to realize and the increase of computation load can be neglected, but the performance of KEGA can be improved greatly. 2. To enhance the speed of AIA, two new methods of computing the concentration of antibody were developed. Simulation results for F8 and F15 (needle in haystack: type I) functions show that the two methods can improve the running speed of AIA more than 8. 5 times. 3. As to the drawback in defining antibody concentration, a new definition based on Euclidean distance between two antibodies and fitness is proposed. On this basis, a new AIA was constructed. The convergence performance are more better than that of AIA. 4. Combining king crossover with AAIA and DBAIA, two new AIAs, KAAIA and DKBAIA, were proposed.

仿真实验结果表明KEGA实现简单，与EGA相比，其增加的计算开销可以忽略，但性能改善十分明显； 2、针对基于信息熵的免疫算法运行速度慢的缺点，提出了二种能够加快AIA运行速度的新的抗体浓度计算方法，得到两种新的免疫算法，即加速的人工免疫算法(Accelerated Artificial Immune Algorithm，AAIA)和加速的人工免疫算法-2（Accelerated Artificial Immune Algorithm-2，AAIA-2），对测试函数F15(needle in haystack：type I)、F8函数的仿真研究表明，这两种算法的运行速度都是AIA的8.5倍以上； 3、针对AIA的浓度定义存在的缺陷，提出了一种新的基于抗体间欧氏距离和适应度的新的抗体浓度定义，并依据该定义构造了一种基于欧氏距离的人工免疫算法(Euclidean Distance-based Artificial Immune Algorithm，DBAIA)。

Based on conal selection principle and K-Nearest Neighbor method, a fault detection algorithm that can produce the valid detector to diagnose fault is designed by the three parts of immune vaccine, immune learning and immune response.

3基于克隆选择原理和K-Nearest Neighbor分类法按照免疫疫苗、免疫学习和免疫应答三个过程设计了能生成有效检测器的故障检测算法。

The effects of cimetidine on cellular immune,fluid immune and erythrocytic immune were observed 1d before operation,1,3,5,7 and 14d after operati...

结论西咪替丁对体外循环心脏直视手术患者的免疫功能有明显的保护作用。

Theoretically, its calculation complexity is studied, while it is tested empirically by learning multi-samples generated randomly. The comparative analysis and applications show it has some merits of rapid searching and good clustering effect. B3. An immune network optimization algorithm with information feedback, which can solve special complex function optimization problems with high dimensions which objective functions are formed by summing multi-subobjective ones, is constructed based on the clone selection principle and the immune network regulation of the idiotype immune network.

为了对免疫系统中抗体如何学习抗原特征的整体行为有一定的认识，从单个抗体识别抗原及多个抗体并行识别抗原的特征出发，利用免疫应答的相关原理及免疫细胞的免疫功能设计了适合于批量样本聚类的抗原特征学习算法，理论上分析了其计算复杂度，获得了此算法中的关键参数与其搜索性能的关系；应用上，该算法通过对实际的多样本学习，获得了搜索速度快及聚类效果好的优点，比较分析表明这种方法是可行的和有效的。

A simple artificial immune network algorithm, suitable for clustering problems with a small quantity of samples, is obtained by using the idiotype immune network. Further, a fuzzy immune network classification algorithm applied to sample classification learning is proposed by uniting the algorithm and fuzzy logical rules.

其次，利用抗原群及抗体群的作用关系，结合免疫记忆细胞的记忆功能，并借助于克隆选择原理、免疫网络的调节机制及约束条件处理方法，设计约束多目标优化免疫算法处理约束多目标优化问题，收敛性论证、性能测试、比较及实际应用表明此算法是有效的。

Based on the clonal selection principle and idiotypic immune network theory exhibited in biological immune system, a new immune algorithm-the clonal selection adjustment algorithm is proposed.

基于生物免疫系统克隆选择机理和独特型免疫网络理论，提出了一种新的免疫算法―克隆选择调节算法。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Chronicity maybe result from many factors with complex mechanism.HCV may evade the host immune surveillance due to the hypermutation of HCV gene; HCV has the nature of pantropic,the tissues outside liver can provide virus for repeatedly infection of liver; The HCV receptors,such as CD81,LDL receptor,scavenger receptor B type I,L-SIGN,DC-SIGN and so on,may influence organism humoral immunity and the cellular immunity function in different degrees; HCV infection also may cause the reduction of quantity of organism immune cell or functional defect,low response of humoral immune response,tolerance of cellular immunity,then,the host finally transforms into chronic infection condition.

其慢性化的机制非常复杂，是由多个因素造成的，HCV因其基因高变性可以逃避宿主的免疫监视；HCV具有泛嗜性，肝外组织又可为肝组织的反复感染提供病毒来源；CD81、LDL受体、清道夫受体B类Ⅰ型及L-SIGN、DC-SIGN等HCV受体又可不同程度地影响机体的体液免疫和细胞免疫功能；HCV感染亦可直接导致机体免疫细胞数量减少或功能缺陷，体液免疫应答水平低下、细胞免疫耐受，宿主最终转变为慢性感染状态。

Detail Contents: Genetic disorders -- Immune deficiencies -- Breast cancer -- Colon cancer -- Melanoma -- Cystic fibrosis -- Hemophilia -- Liver disease -- Cardiovascular disease -- Muscular dystrophy -- Alzheimer's disease -- Parkinson's disease -- Huntington's disease -- Viruses: the cornerstone of gene therapy -- Viruses are living crystals -- Viral genomes may be RNA or DNA -- Viruses evolved from plasmids -- Viruses know how to infect cells -- The virus as a gene vehicle -- Viruses used in gene therapy -- Ashi DeSilva: a promising start -- Clinical trials defined -- Cells of the immune system -- Adenosine deaminase -- Preliminary research -- Clinical procedure for ADA gene therapy -- The DeSilva clinical trial -- Jesse Gelsinger: down to earth -- Ornithine transcarbamylase -- Preliminary research -- Clinical procedure for OTC gene therapy -- The Gelsinger clinical trial -- The investigation -- Concluding remarks -- Future prospects -- Safer vehicles -- Reducing immune rejection of the vector -- Improved risk assessment -- Redesigning human anatomy and physiology -- Ethics of gene therapy -- The Belmont report -- Clinical trials -- Physiological enhancement -- Cosmetic applications -- Legal issues -- Regulatory agencies -- The Gelsinger legal trial -- International regulation -- Resource center -- Eucaryote cell primer -- Recombinant DNA primer -- The human genome project -- X-linked severe combined immunodeficiency (SCID-X1)-- Alzheimer's disease -- Huntington's disease.

细节内容︰遗传疾病-免疫的缺乏-乳腺癌-结肠癌-黑瘤-囊性纤维变性-血友症-肝疾病-心血管疾病-肌营养不良-早老性痴呆病-帕金森疾病-亨廷顿疾病-病毒︰基础的基因治疗-病毒在活著水晶--病毒的基因可能是RNA或者DNA --病毒从plasmids被逐步形成--病毒知道怎样感染细胞--作为一辆基因车辆的病毒--基因治疗使用的病毒-Ashi DeSilva︰有希望开始-临床试验确定--细胞的这免疫系统-Adenosine deaminase-初步研究-临床程式给埃达基因治疗--这DeSilva临床试验-婕西Gelsinger︰到地球-Ornithine transcarbamylase-初步研究-临床程式给OTC基因治疗-- Gelsinger临床试验-调查-达成评论-前景-更安全的车辆--矢量的降低免疫的拒绝-改进风险估计-重新设计人解剖学和生理学--伦理学的基因治疗-那些贝拉蒙特报告-临床试验-生理提升-美容应用-法律问题-协调机构-- Gelsinger 合法审讯-国际管理-资源中心人物-Eucaryote信元第一-Recombinant DNA 入门--人类基因工程-- X 连结的严重的结合的免疫缺陷(SCID-X1)-早老性痴呆病--亨廷顿的疾病。

This immune algorithm-- is proposed with analogy to the concept and the theory of immunity in biotic science. The core of the algorithm lies in constructing the immune operator that is realized by vaccination and immune selection.

该免疫算法是借鉴生命科学中免疫的概念与理论提出的一种新的算法，算法的核心在于免疫算子的构造，即接种疫苗和免疫选择。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失