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The application of BRM only then fight cancer, but absolutely not be confined to fights cancer, it is right infection (include slow virus, helminth to affect), immune blemish , disease of immune interpose different the prevention and cure that wait, down to fights anile, health care to having fundamental value etc.

BRM 的应用始开抗癌,但绝不限于抗癌,它对感染(包括慢病毒、寄生虫感染)、免疫缺陷、免疫介异疾病等的防治,以至抗衰老、保健等等都有着重要的价值。

Compared with classical cytotoxic T lymphocytes , NK cells are superior in the following aspects: NK cells are among the first cell types to be activated after intracellular pathogen stimuli, the activity of NK cells peaked between 1 to 3 days, retained during the first 7-10 days, and the T cells response emerged only after 7 days when the NK cell responses begin to decline; though comprising of only 10%-15% of peripheral lymphocytes, NK cells mobilize most of the cell populations in a strong and high level response to different invasions, and act as key factors at early defense before a specific immune response could mount, while only certain clones were involved in T cell response; NK cells kill virus-infected or malignant transformed cells without pre-sensitization and without restriction by major histocompatibility antigen, which is usually a mechanism of immune escape to T cell recognition by virus-infected or tumor cells, thus NK cell in complementary with T cells play crucial roles in tumor and virus eradication.

NK细胞以其强大的细胞毒活性为特征,与细胞毒性T细胞相比,NK细胞具有如下特点:NK细胞虽然只占外周血淋巴细胞的10-15%,但是对刺激性因素产生应答的过程十分迅速,一次可以调动大多数细胞共同参与,而不是几个克隆的活化,免疫应答的强度高;病毒感染或恶性转化细胞的一个主要特征是细胞表达的MHCⅠ类分子下降或消失,并借助这一机制逃避特异性T细胞应答的识别,NK细胞介导的杀伤活性无需抗原刺激,不受MHCⅠ分子表达的限制,从而与T细胞应答互为补充发挥免疫防御的功能;NK细胞的免疫活性可以被多种细胞因子上调,其中IFNα,IL-2,IL-12,IL-15和IL-18具备更强的作用;NK细胞具有强大的细胞因子分泌功能,对于启动T细胞特异性应答必不可少。

The whole immune enhancement of bacterial DNA adjuvants was weaker than aluminium oxyhydrogen adjuvant, but bacterial DNA adjuvants could induce Th1 immune response in vivo, activate immune cells to kill pathogenic microbe.

细菌DNA佐剂的整体免疫增强作用弱于氢氧化铝佐剂,但其能在体内诱导Th1型免疫应答,使IgG2a/IgG1比值上升,激活免疫细胞杀灭病原体。

the Chinese herbs-Qiang ji kang have the bidrectional immune regulation function to the cellular immune responses of the immunosthenic and Immunorepressive mice . it can decrease the humoral immune responses of the Immunorepressive mice. It have anti-inflammafory and abirritation

中药强脊康对机体亢进和抑制的细胞免疫功能起到双向调节作用,能抑制亢进的体液免疫功能;并对急慢性炎症具有一定的抑制作用,镇痛作用明显、持久,但起效慢。

Based on conal selection principle and K-Nearest Neighbor method, a fault detection algorithm that can produce the valid detector to diagnose fault is designed by the three parts of immune vaccine, immune learning and immune response.

3基于克隆选择原理和K-Nearest Neighbor分类法按照免疫疫苗、免疫学习和免疫应答三个过程设计了能生成有效检测器的故障检测算法。

A simple artificial immune network algorithm, suitable for clustering problems with a small quantity of samples, is obtained by using the idiotype immune network. Further, a fuzzy immune network classification algorithm applied to sample classification learning is proposed by uniting the algorithm and fuzzy logical rules.

其次,利用抗原群及抗体群的作用关系,结合免疫记忆细胞的记忆功能,并借助于克隆选择原理、免疫网络的调节机制及约束条件处理方法,设计约束多目标优化免疫算法处理约束多目标优化问题,收敛性论证、性能测试、比较及实际应用表明此算法是有效的。

Chronicity maybe result from many factors with complex mechanism.HCV may evade the host immune surveillance due to the hypermutation of HCV gene; HCV has the nature of pantropic,the tissues outside liver can provide virus for repeatedly infection of liver; The HCV receptors,such as CD81,LDL receptor,scavenger receptor B type I,L-SIGN,DC-SIGN and so on,may influence organism humoral immunity and the cellular immunity function in different degrees; HCV infection also may cause the reduction of quantity of organism immune cell or functional defect,low response of humoral immune response,tolerance of cellular immunity,then,the host finally transforms into chronic infection condition.

其慢性化的机制非常复杂,是由多个因素造成的,HCV因其基因高变性可以逃避宿主的免疫监视;HCV具有泛嗜性,肝外组织又可为肝组织的反复感染提供病毒来源;CD81、LDL受体、清道夫受体B类Ⅰ型及L-SIGN、DC-SIGN等HCV受体又可不同程度地影响机体的体液免疫和细胞免疫功能;HCV感染亦可直接导致机体免疫细胞数量减少或功能缺陷,体液免疫应答水平低下、细胞免疫耐受,宿主最终转变为慢性感染状态。

By comparing the body weight, immune organs index and response of lymphocytes to ConA, to analyze the effect of QKL on immunological system of normal mouse. Delayed type hypersensitivity mouse model was established by stimulation with dinitrofluorobenzene. By comparing spleen index and swelling rate of pathogenetic ear, to illuminate the immunoregulation of QKL in vivo. Polymicrobial sepsis mouse model was induced by cecal ligation and puncture. The cumulative survival rate was observed in QKL and NS groups. Results: QKL had no influence on body weight and spleen index of normal mouse, but it could significantly decrease thymus index and inhibit the immune response of lymphocytes to ConA.

连续皮下注射QKL 5 d,通过检测小鼠体重、免疫器官指数和淋巴细胞对ConA刺激的反应,分析QKL对正常小鼠免疫功能的影响;采用二硝基氟苯诱发小鼠耳朵肿胀,发生接触性皮炎,建立DTH模型,通过比较QKL与NS对照对小鼠脾脏指数和发病耳肿胀抑制率评价QKL体内对小鼠的免疫调节功能;采用盲肠结扎穿孔术后引起的多细菌性腹膜炎,建立小鼠脓毒症模型,通过观察QKL对小鼠存活状况的影响,评价QKL的免疫调节作用。

This immune algorithm-- is proposed with analogy to the concept and the theory of immunity in biotic science. The core of the algorithm lies in constructing the immune operator that is realized by vaccination and immune selection.

该免疫算法是借鉴生命科学中免疫的概念与理论提出的一种新的算法,算法的核心在于免疫算子的构造,即接种疫苗和免疫选择。

The immune regulation, clone selection, immune memory were brought into standard genetic algorithm to design genetic immune algorithm for solving mixed transportation network design in view of the limitations of standard genetic algorithm and based on immunity theory.

鉴于标准遗传算法的局限性,基于人工免疫思想,将免疫系统仿生机理中的免疫调节、克隆选择、免疫记忆引入到遗传算法中,给出了求解混合交通网络设计的遗传免疫算法。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。