查询词典 idiotypic

The rearranged idiotypic CDR3 fragments coding TCR Vβ8 of the Jurkat cell strain and TCR Vβ2 of the Molt4 cell strain were amplified using RT-PCR, and then were cloned into pIRES vector respectively.

用RT-PCR方法扩增特异性重排的Jurkat细胞TCR Vβ8 CDR3序列和Molt4细胞TCR Vβ2 CDR3序列，分别克隆到真核表达载体pIRES中。

Such responses can be induced through the induction of antibody-dependent cellular cytotoxicity, promotion of antibody-targeted cross-presentation of tumour antigens, or by triggering of the idiotypic network.

通过诱导抗体依赖性细胞毒性效应、刺激抗体靶向的肿瘤抗原交叉提呈或触发独特型网络，均可诱导该类应答。

In order to increase the diversity of population, MFCMGA uses idiotypic immune network theory to improve the selection operator of SGA. Meanwhile in order to decrease the randomicity of SGA, the crossover probability, crossover position and mutation probability are adjusted dynamically by using fuzzy inference, which is based on analyzing the heuristic fuzzy relationship between algorithm performance and evolutionary parameters from the viewpoints of environment, population, individual and gene.

该算法利用免疫系统独特性网络学说，改进标准遗传算法选择运算子，提高了种群多样性；同时从环境、种群、个体和基因角度，全面分析算法寻优性能和各种进化参数的启发式模糊关系，采用模糊推理动态调整交叉率、交叉位置和变异率，减小了标准遗传操作的随机性。

In the bid to increase the diversity of population, MFCMGA uses idiotypic immune network theory to improve the selection operator of SGA. Simultaneously, in order to decrease the randomicity of SGA, the crossover probability, crossover position and mutation probability are adjusted dynamically by using fuzzy inference, which is based on analyzing the heuristic fuzzy relationship between algorithm performance and evolutionary parameters from the viewpoints of environment, population, individual and gene.

该算法利用免疫系统独特性网络学说，改进标准遗传算法选择算子，提高了种群多样性；同时从环境、种群、个体和基因角度，全面分析算法寻优性能和各种进化参数的启发式模糊关系，采用模糊推理动态调整交叉率、交叉位置和变异率，减小了标准遗传操作的随机性。

Schistosomides ; Antibody ; anti idiotypic ; Goats

血吸虫；日本；抗体；抗独特型；山羊

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

This phenomenon may have implications for the preventive use of anti-idiotypic antibody against toxicosis of organophosphorus agents.

此结果说明该抗体有希望成为针对有机磷毒剂，尤其是梭曼的预防性和早期治疗性药物。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。