查询词典 idiotype

In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.

为了降低人抗鼠抗体反应，获得满意的免疫原性，将模拟人卵巢癌抗原的抗独特型单链抗体人源化。

Antibodies induced by allo-TCV may be involved in the mechanisms of T cell vaccination, which include anti -idiotype antidoby specific to allo-T cell vsccine.

淋巴细胞特异的抗体产生，它们均以不同的方式作用于T淋巴细胞。干扰了淋巴细胞的活化，引起免疫小鼠同种移植物的延长。

Methods PI 1 anti idiotype monoclonal antibodies against pemphigus and purified PAb from the serum of a patient with active pemphigus were used to establish an ELISA system for detecting the PAb.

目前常用的PAb检测法为免疫荧光法和免疫印迹法等，都需要一定的实验条件，难以在临床推广使用。

The idiotype TCR Vα1-pIRES-TCR Vβ8 eukaryotic vectors were developed successfully, it would be provided the basic data for the study on specific TCR gene modified T cells.

成功构建了独特型TCR Vα1-pIRES-TCR Vβ8双基因表达载体，为利用特异性TCR基因修饰T细胞的研究提供了基础资料。

Objective: To investigate the situation of TCR Vβ gene repertoire and clonal expansion in peripheral blood T cells from patients with acute lymphoblastic leukemia and T cell strains, and analysis the expressive characters of TCR V β gene idiotype. To develop the anti-lymphoblastic leukemia TCR idiotypic DNA vaccine.

目的：了解淋巴细胞白血病及T细胞株的TCRVβ基因谱系及其克隆性增殖情况，分析TCR Vβ基因独特型表达的特点，并构建具有抗淋巴细胞白血病作用的TCR独特型DNA疫苗。

Theoretically, its calculation complexity is studied, while it is tested empirically by learning multi-samples generated randomly. The comparative analysis and applications show it has some merits of rapid searching and good clustering effect. B3. An immune network optimization algorithm with information feedback, which can solve special complex function optimization problems with high dimensions which objective functions are formed by summing multi-subobjective ones, is constructed based on the clone selection principle and the immune network regulation of the idiotype immune network.

为了对免疫系统中抗体如何学习抗原特征的整体行为有一定的认识，从单个抗体识别抗原及多个抗体并行识别抗原的特征出发，利用免疫应答的相关原理及免疫细胞的免疫功能设计了适合于批量样本聚类的抗原特征学习算法，理论上分析了其计算复杂度，获得了此算法中的关键参数与其搜索性能的关系；应用上，该算法通过对实际的多样本学习，获得了搜索速度快及聚类效果好的优点，比较分析表明这种方法是可行的和有效的。

In conclusion, a prokaryotic plasmid, encoding the fusion gene of single-chain variable fragment with MCP-3 and expressing idiotype protein vaccination against B cell lymphoma, was constructed correctly.

本研究成功构建鼠源scFv片段与趋化因子MCP-3融合的独特型B细胞淋巴瘤疫苗表达质粒pGLo/scFv- MCP-3，并实现融合蛋白的初步表达。

A simple artificial immune network algorithm, suitable for clustering problems with a small quantity of samples, is obtained by using the idiotype immune network. Further, a fuzzy immune network classification algorithm applied to sample classification learning is proposed by uniting the algorithm and fuzzy logical rules.

其次，利用抗原群及抗体群的作用关系，结合免疫记忆细胞的记忆功能，并借助于克隆选择原理、免疫网络的调节机制及约束条件处理方法，设计约束多目标优化免疫算法处理约束多目标优化问题，收敛性论证、性能测试、比较及实际应用表明此算法是有效的。

Two idiotype TCR Vα1-pIRES-TCR Vβ8 recombinant eukaryotic vectors weredeveloped successfully, and the expression of both idiotypic TCR mRNA and proteincould be detected in transferred A549、K562 and Molt4 cells.

2成功构建了两组TCR Vα1-pIRES-TCR Vβ8表达载体，该表达载体转染A549、K562和Molt4细胞后，可表达相应的mRNA和蛋白。

The experiments may contribute not only to investigating the mechanism of interaction between ldiotype and anti -idiotype T cells by which immune network are up-regulated, but also to analysing the suppressive effect of anti -idiotypic T cell or antibodies against the antigens on the activated T cells in the allo-responsiveness.

本课题选用小鼠耳后心肌移植模型，用同种抗原特异的活化T淋巴细胞免疫同系小鼠的方法，诱导免疫小鼠同种心肌移植物存活时间的延长，以此探讨免疫网络中独特型-抗独特型相互作用机理，着重分析在同种抗原诱导的免疫应答中，抗独特型T细胞和抗活化T淋巴细胞抗原抗体对同种免疫反应的抑制作用。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。