查询词典 hypoxia

OLH or 8-bromo-cAMP were added to luteinized granulosa cells. Results indicated that, protein expression of HIF-1a, HIF-1b and VEGF had a better performance in hypoxia than in normoxic condition, but phospho-PKA, StAR and P450scc protein expression had weaker expression in the former condition than in the later one. As a result of decreasing secretion of progesterone the decreasing of phospho-PKA was suspected to have a role in the reduction of StAR and P450scc in the condition of hypoxia.

结果发现，黄体化粒性细胞於缺氧条件下其HIF-1a、HIF-1b与VEGF蛋白质表现量皆较正常氧高；同时，StAR及P450scc蛋白质表现量则降低，但3b-HSD不受缺氧影响；此外，藉由特异性抗体检测PKA讯息传递路径发现，PKA讯息传递路经於缺氧条件下磷酸化PKA（phospho-protein kinase A）蛋白质表现量下降，可能经此路径的调控造成StAR及P450scc蛋白质表现量下降，导致黄体化粒性细胞孕酮分泌量减少。

Effects of intermittent hypoxia, cold, restraint and their combinated stresses on the level of insulin secretion Simulated 2 km intermittent hypoxia (4 hours/day, continuation for 15 days) didn"t significantly influence rats" body weight gain.

间歇性低氧、低温、束缚及其复合应激对胰岛素分泌水平的影响模拟2km间歇低氧(4小时／天，连续15天)对大鼠的体重增重没有显著影响，而模拟5km间歇低氧(4小时／天，连续15天)显著抑制大鼠体重增重。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

中文摘要缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

HIF-1α is an oxygen-regulated protein and is recognized as a positive factor to tumorigenesis. During nomoxia, HIF-1α is rapidly hydroxylated by prolyl hydroxylase then goes into 26S proteasome degradation pathway. During hypoxia, HIF-1α accumulates and dimerizes with HIF-1β to transactivate hypoxia-responsive gene expression.

缺氧诱导性因子-1α(HIF-1α)为一种对於氧分压敏感的转录因子，在正常氧分压下HIF-1α很快就被prolyl hydroxylase氢氧化进入26S蛋白酶体降解，当细胞处理缺氧环境时HIF-1α会累积并与HIF-1β形成复合物进行转录活化的作用；HIF-1α所调控的基因包括影响能量供给、细胞生长、血管新生等，被认为在肿瘤发育过程扮演促进者的角色。

Cell lines were co-tranfected with bi-plasmids and cultured at 1% O〓 condition, luciferase assay demonstrated that all of the expression systems with different domains could be hypoxia-activated. GAL-CAD achieved more than 100-fold induction in A549 cell and more than 40-fold in HepG2; expression level of the system markedly increased after addition of glycin arm, almost 10-fold enhancement in HepG2 cell. Because basic expression also increased, the induction fold by hypoxia decreased.

双质粒共转染不同细胞株后，在1％O〓环境下培养24h，荧光素酶活性检测结果提示含不同结构域的表达系统均有受缺氧激活的能力，其中GAL-CAD在A549中获得100倍以上的诱导，在HepG2中获得40倍以上的诱导；加入甘氨酸臂后该表达系统的转录活性大为增强，在HepG2细胞中增强了10倍以上，但是由于基础表达也有所增加，受缺氧诱导的倍数下降。

objective to investigate whether hypoxia preconditioning exist in adipose tissue,and construct the hypoxemic model of adipose tissue.methods after injected different density cocl2 to rat's subcutaneously of groin,use immunohistochemical method detect hif-1α protein,and use rt-pcr detect hif-1α mrna.results after injected different density cocl2,the adipose tissue of rat's groin express different degree of hif-1αprotein and hif-1αmrna.,and reach the peak when the density is 20-40 mg/kg and the time is 3 h.conclusion hypoxia preconditioning exist in adipose tissue,and the effect of preconditioning is most evidence when the density is 20-40 mg/kg and the time is 3 h.

目的 探讨脂肪组织中是否存在缺氧预适应现象，构建cocl2致缺氧的缺氧模型。方法不同浓度的cocl2大鼠腹股沟区皮下层浸润注射，分别用免疫组织化学法和rt-pcr法检测该区脂肪hif-1α蛋白和hif-1α mrna的表达情况。结果用不同浓度的cocl2行化学缺氧后在不同时间点观察有不同程度的hif-1α蛋白和hif-1α mrna表达，其中，在浓度为20～40 mg/kg，时间为3 h时脂肪组织中hif-1α表达达高峰。结论脂肪组织存在缺氧预适应现象；cocl2的浓度选择20～40 mg/kg，时间选择3 h时缺氧预适应效果较佳。

Aim:(1) The purpose of this study is to examine whether protein tyrosine kinase and AMPA receptor in the nucleus tractus solitarius and nucleus ambiguus were involved in the regulation of normoxia and hypoxia respiratory response by microinjection of PTK inhibitor and non-NMDA receptor antagonist;(2) To observe the change of number of phosphotyrosine immunopositive neurons in NTS and NA before and after hypoxia using immunohistochemical methods and whether tyrosine phosphorylation and GluR1 in postsynaptic membrane co-localize in NTS and NA neurons.

目的：(1)观察向家兔脑干孤束核或疑核内微量注射酪氨酸蛋白激酶阻断剂和谷氨酸AMPA受体阻断剂对常氧呼吸和低氧呼吸反应的影响，探讨PTK和AMPA受体在低氧呼吸反应中的作用。(2)观察低氧通气后NTS和NA磷酸化酪氨酸免疫阳性神经元的数量变化；观察磷酸化酪氨酸和AMPA受体亚单位GluR1在突触后膜共存的情况，推测在低氧呼吸反应中AMPA受体和PTK信号转导途径的关系。

Methods Wistar rats were randomly divided in to four groups: normal control group,high altitude hypoxia group,soman intoxication group and hypoxia +soman intoxication group.

实验大鼠随机分为正常对照组、高原缺氧组、梭曼中毒组和缺氧复合梭曼中毒组。

In conclusion, our research has indicated that amine oximes or other hypoxia imaging agents might not be structure-specific pharmaceuticals, and lipophilicity seemed to be an important factor in design for hypoxia agents.

由于〓Tc〓-〓在胃肠道等脏器分布较多，难以检测腹腔肿瘤，但可广泛适用于其它部位实体瘤的诊断。而上述三者更集中于肝、肾，可能适用于某些胃肠道肿瘤和妇科肿瘤的乏氧显像。

This article introduces the effect of high central nervous system,changes of cerebral blood flow after hypoxia,damage of hypoxia to neurons in the respiratory center,neurotransmitters and neuromodulators in hypoxic respiratory depression.

Barnard等[2]在成年动物也发现了类似的情况，并且指出，缺氧2h内，颈动脉窦传入神经放电一直加强。以上研究结果提示，不论在新生动物还是成年动物，缺氧性呼吸抑制的发生都有其中枢来源。

Alternatively, the con- trollers can use the synchronous rectifier itself or loss- less inductor current-sensing methods to provide overload protection with lower power dissipation.

另外，康威特罗勒斯可以使用同步整流器本身或亏损减少电感电流检测方法，以提供低功耗过载保护。

Mr. Dauber's other Schatz hangs in his home movie studio.

多伯把沙兹的另一件作品挂在家里的电影室。