查询词典 hydroxy-indole

Hydroxy-2,3-dihydro-4-quinolone is synthesized by the basic material of 4-nitrochloro-benzene. It has investigated the routes, conditions and purifies methods in this paper, which provides bases to lucubration and industrialization. This study belongs to the field of medical intermediates.

本文以4-硝基氯苯和丙烯酸为基础原料合成6-羟基-2，3-二氢-4-喹啉酮，并对6-羟基-2，3-二氢-4-喹啉酮的合成条件和纯化方法进行了实验研究，为后续的深入研究和工业化生产提供依据。

That is, the biological efficacy of liquid methionine hydroxy analogue is only 65% in pig.

因此，液体蛋氨酸羟基类似物对猪的生物学效价只有65%。

Biological assays for several PAHs containing hydroxy and nitro group indicated that they could protect human red blood cells from hemolysis induced by AAPH and displayed effect of inhibitory for damage of DNA in vitro. They were found to have cytostatic and cytotoxic activity for HL-60 cell lines.

所考察的含有羟基和硝基的多环芳烃化合物对自由基诱导的人血红细胞溶血有一定的抑制作用，对AAPH诱导的DNA损伤有不同程度的保护作用，且它们的抗氧化活性与硝基取代基之间表现出一定的构效关系。

The hydroxy and nitro-substituted coumarins were able to inhibite hemolysis of human red blood cells and damage of DNA induced by AAPH. It reveals that these compounds are effective antioxidants. Some coumarins have cytostatic and cytotoxic activity for HL-60 cell lines. In general, their effects were weakened when coumarins own nitro group.

含有羟基和硝基的香豆素衍生物对自由基诱导的人血红细胞溶血有一定的抑制作用，且对AAPH诱导的DNA损伤有不同程度的保护作用，部分香豆素衍生物对人早幼粒白血病细胞（HL-60）的增殖表现出一定的抑制作用。

We described that the nitro group is a stronger electron withdrawing and meta activating characters than the imide group, the amino and hydroxy are both electron donating groups and had ortho, para activating characters. The methyl group might have a steric hindrance effect in this reaction. Our results indicated that methyl group at the ortho position of the amino group on the benzene ring, the steric hindrance effect became stronger.

另一方面，由产率上的结果来看，可以得知硝基为强力的拉电子基团，会减少邻位和对位胺基的电子密度比间位多；而氢氧基与胺基是供电子基团，会增加邻位和对位胺基的电子密度比间位多；甲基取代对反应则只有立体障碍的影响，而且与反应的氨基成邻位存在下影响最大。

With polyoxyethylene nonyl phenol ethers (OP-10) as emulsifier and dodecyl benzene sulfonic acid as catalyst, hydroxy organosilicon microemulsion was prepared through octamethylcyclotetrasiloxane (D4) open-ring polymerization under certain conditions.

以壬基酚聚氧乙烯醚(OR-10)作乳化剂，十二烷基苯磺酸为催化剂，通过八甲基环四硅氧烷(D4)开环聚合，在一定条件下合成了端在基聚二甲基硅氧烷微乳液。

Diketoreductaseis a class of new enzyme, and compared with other oxidoreductase, whose uniqueness lies in its ability to restore at the same time reduced to two hydroxy carbonyl and a high degree of stereoselectivity.

双羰基还原酶（Diketoreductase，简称DKR）是一类全新的酶，与其他的氧化还原酶相比，其独特之处在于它能够同时还原两个羰基还原成羟基，并有高度的立体选择性。

During the manufacturing of the critical intermediate cephalosporin nucleus --7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt, first the feasibility of the one-pot synthetic route of open loop, closed loop and ozonization when chlorine is passed over is qualified by experiments. Then the critical factors that will influence this reaction are studied as follows: the mol ratio of triphenyl phosphite and Diphenylmethyl 3-hydroxy-7-phenylacetaminoceph-3-em-4-carboxylate-l-oxide is four to one; the quantity of the stablizer should be at least more than two to one. The temperature of the system must be 25℃ when chlorine is passed over so that the hydrochloride can be precipitated to obtain cephalosporin nucleus of cefaclor--7-amino-3-chloro-cephalosporanic acid diphenylmethyl ester hydrochloride salt.

在制备关键中间体头孢母核7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐时，先通过实验验证把开环、闭环、臭氧化三步在通入氯气时并为一锅煮的合成路线的可行性之外，又研究了影响该反应的几个重要因素：亚磷酸三苯酯与3-羟基-7-头孢烷-5-亚砜-2-甲酸二苯甲酯的摩尔比为4：1；稳定剂2-甲基-2-丁烯的用量至少大于2：1，通入氯化氢气体时体系温度在25℃时盐酸盐则能够顺利析出，获得头孢克洛的头孢母核—7-氨基-3-氯头孢烷酸二苯甲酯盐酸盐。

Methods: In this paper, a quinazoline purine analogues for the parent nucleus, respectively, and four of its seven introduced to replace the structure of diverse and flexible side-chain amino-benzene, design a series of 4 - to replace the aniline-based -6 - methoxy --7 -(2 - hydroxy replace C oxy) quinazoline compounds.

目的：通过各种化学合成方法完成目标化合物4--6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉的合成并对目标化合物进行结构修饰，以期获得高活性的表皮生长因子受体酪氨酸激酶抑制剂。

Therelationship of the amount of catalyst and the ee% of product was seen to be negative nonlin-ear. Catalyst 3 was used in the enantioselective addition of diethylzinc to aromatic aldehydesand gave good results. The configuration of products was determined by the configuration ofthe catalysts' chiral carbon linked with hydroxy group. Using β- amino alcohols bearing only one chiral center as catalysts for the enantiose-lective addition were studied. D-N, N-dialkyl-2-amino butanol gave poor catalytic effect be-cause of their structure. The configuration of the product is the same as the catalyst. Anotherkind of β- amino alcohols - phenylglycine derivatives and valine derivatives have chiralcenter on the carbon linked with amino group. Catalyzed by-phenylglycine derivatives 6,7, 9, 10, the reactions gave satisfied results. The optical yields exceeded 80%.

在探讨了含有两个手性中心的β-氨基醇之后，选择了只有一个手性中心的β-氨基醇，一是手性中心为连羟基的手性碳原子：D-N，N-二烷基-2-氨基丁醇；二是手性中心为连氨基的手性碳原子：D-苯基甘氨酸衍生物和L-缬氨酸衍生物。D-2-氨基丁醇的催化效果不太好，这与其结构的空间位阻较小有关系，反应产物与连羟基手性碳构型一致；由苯基甘氨酸和缬氨酸出发合成五种β-氨基醇6-10，研究了不同ee％的-6作用下的二乙基锌-苯甲醛加成反应，发现该催化剂具有不对称放大效应；-7，9，lO的催化效果也比较令人满意，光学产率80％以上，所得产物构型与催化剂构型一致。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。