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Immunofluorescence confirmed that sweat glands in normal mice did not present gamma-aminobutyric acid receptor subtype GABAA andα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainic acid subtype of glutamate receptor. Mature mice with reactive sweat glands that declined more than 25% compared to baseline were defined as anhidrotic mice.

免疫组织荧光染色未发现在正常小鼠皮肤组织及汗腺的分泌细胞存在γ-氨基丁酸A型(gamma-aminobutyric acid,GABAA)受体α1亚单位、谷氨酸受体亚型α-氨基羟甲基恶唑丙酸(α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid , AMPA )GluR1/2/3/4亚单位和海人酸(kainic acid,KA)受体GluR5/6/7亚单位的表达。

Immunofluorescence confirmed that sweat glands in normal mice did not present gamma-aminobutyric acid receptor subtype GABAA andα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainic acid subtype of glutamate receptor.Mature mice with reactive sweat glands that declined more than 25% compared to baseline were defined as anhidrotic mice.

免疫组织荧光染色未发现在正常小鼠皮肤组织及汗腺的分泌细胞存在γ-氨基丁酸A型(gamma-aminobutyric acid,GABAA)受体α1亚单位、谷氨酸受体亚型α-氨基羟甲基恶唑丙酸α-amino(来源:Ad1d1BC论文网www.abclunwen.com-3-hydroxy-5-methylisoxazole-4-propionic acid , AMPA GluR1/2/3/4亚单位和海人酸(kainic acid,KA)受体GluR5/6/7亚单位的表达。

The present invention relates to a novel compound and its uses, which is an extract isolated and purified from Antrodia camphorate, in particular to 4-hydroxy- 2,3- dimethoxy- 6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-- enone, and its use in tumor growth inhibition.

大意:本发明涉及一种从牛樟芝提取分离、纯化的新型化合物抑制癌细胞活性成分4-hydroxy-2,3- dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl-cyclohex-2-enone及其用途,使用在肿瘤生长的抑制作用。

Alpha hydroxy acid applied daily will help prevent acne out breaks if you have acne prone skin.

应用的阿尔发 hydroxy 酸每日的将会帮助出自休息避免痤疮如果你有痤疮俯伏的皮肤。

Microbeads sweep away dead skin cells, while Beta Hydroxy Acid deep cleans, removing oil and excess dirt.

产品里得小颗粒可以去掉死细胞,Beta hydroxy acid可以深层清洁掉油脂和脏东西。

However, the first one enzyme 1-deoxy-D-xylulose 5-phosphate synthase gene and the second one enzyme 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene in MEP pathway had been reported and expressed in the latex of rubber tree, indicating that MEP pathway may be involved in rubber biosynthesis.4 - hydroxy -3 - methyl -2 -- butenyl -4 - phosphate reductaseis the last enzyme that catalytic 4 - hydroxy -3 - methyl -(2E)- butenyl -4 - phosphate to generate isopentenyl pyrophosphate.

然而已有报道MEP途径中第1个酶1-脱氧-D-木酮糖-5-磷酸合成酶(1-deoxy-D-xylulose 5-phosphate synthase,DXS)基因和第2个酶1-脱氧-D-木酮糖-5-磷酸还原酶(1-deoxy-D-xylulose 5-phosphate reductoisomerase ,DXR)基因在橡胶树胶乳中的表达,这表明MEP途径可能参与橡胶的生物合成。4-羟基-3-甲基-2--丁烯基-4-磷酸还原酶(4-hydroxy -3-methyl-2--butenyl-4-diphosphate reductase,HDR)是异戊烯基焦磷酸合成途径之一甲基赤藓糖磷酸(methylerythritol phosphate,MEP)途径中的最后一个酶,催化4-羟基-3-甲基-(2E)-丁烯基-4-磷酸生成异戊烯基焦磷酸。

We evaluated the photooxidative DNA damage, indicated by the specific content of 8-hydroxy-2'- deoxygaunosine (8-OHdG), in human pterygium. In addition, we analyzed the relationship between the genetic polymorphism of the DNA repair enzyme hOGG1 and the pterygium risk in a Chinese population.

首先,我们尝试以8-氢氧-2'-去氧鸟粪核糖苷( 8-hydroxy-2'- deoxyguanosine, 8-OHdG )为指标,找出眼翳组织中去氧核糖核酸( deoxyribonucleic acid, DNA )所受到的光氧化性损伤之证据。

Tetrahydroisowuinolin derivatives and phthalide derivatives were designed and synthesized on the basis of a PDE4 inhibitor pharmacophore model set up through computer simulation. Some tetrahydroisowuinolin derivatives synthesized were evaluated on their activity against PDE4 for study on the structure-activity relationship.(7-cyclopentyloxy)-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155) and Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (170) showed good activity against PDE4, which were chosen as the lead compounds to design and synthesize another analogs in order to develop selective PDE4 inhibitors with better activity.

分别设计合成了以四氢异喹啉和氨基苯酞为骨架的两类小分子杂环化合物,并对部分四氢异喹啉衍生物测试了其相关的生物活性,初步确定了其构效关系,发现了两个对PDE4有较好抑制活性的先导化合物(7-cyclopentyloxy)-6-methoxy-3,4-dihydroisoquinolin-2(1H)-yl(4-hydroxy-3-methoxyphenyl)methanone (155)和Methyl 7--6-methoxy-2-(4-methoxy- benzoyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (170)。

Twenty-seven compounds were isolated from the methanol extract of the stems of Pinus massoniana by means of chromatographic methods, and their structures were elucidated as 8(14),15-Pimaradien-19-oic acid (1), Pimaric (2), Podocarpic acid (3), 12-Hydroxydehydroabietic acid (4), Dehydroabietic acid (5), 15-Hydroxydehydroabietic (6), 3β-Methoxyserrat-14-en-21-one (7), 3β-Hydroxy- serrat- 14-en-21-one (8), 3β-Methoxyserrat-14-en-21-one-30-al (9),(24R)-Stigmst- 4-ene-3-one (10),β-sitosterol (11),-3-Hydroxy-5-methoxy-stilbene(12), 4-Hydroxy-3- methoxycinnamaldehyde (13),-Ferulic acidtetracosyl ester (14), Alkylferulates (15), Pinocembin (16), Coniferaldehyde (17), Matairesinol (18),-Nortrachelogenin (19), Balanophonin (20), Cedrusin (21),-Pinoresinol (22), Tanegoside (23), 1,2-Bis-(4-hydroxy-3- methoxyphenyl)-propane-1,3-diol (24),(1S*, 2S*)-1-(4- Hydroxyphenyl) glyceri...

同时对马尾松枝条的甲醇提取物利用各种色谱技术进行了分离纯化,并利用现波谱技术鉴定了27个化合物的结构,分别为:8(14),15-Pimaradien-19-oic acid (1)、海松酸(2)、罗汉松酸(3)、12-羟基脱氢松香酸(4)、脱氢松香酸(5)、15-羟基-脱氢松香酯(6)、3β-甲氧基-锯齿石松-14-烯-21-酮(7)、3β-Hydroxyserrat-14-en-21-one (8)、3β-Methoxyserrat-14-en-21– one-30-al (9)、(24R)-豆甾-4-烯-3-酮(10)、-3-羟基-5-甲氧基-二苯乙烯(12)、4-Hydroxy-3-methoxycinnamaldehyde (13)、-Ferulic acidtetracosyl ester (14)、Alkylferulates (15)、Pinocembin (16)、Coniferaldehyde (17)、罗汉松树脂酚(18)、 Balanophonin (20)、tanegoside (23)、1,2-Bis-(4-hydroxy- 3-methoxyphenyl)-propane- 1,3-diol (24)、(1S*,2S*)- 1-(4-hydroxyphenyl)glycerins (25)、(1R*,2R*)-1-(4-hydroxy- phenyl)gly-cerins (26)和赤松素(27)。

Ursolic acid (UA; 3-β-hydroxy-urs-12-en-28-oic acid), a constant constituent of Rosmarinus officinalis extracts, is a triterpenoid compound which has been shown to have antioxidant and anticarcinogen properties.

乌苏酸 (Ursolic acid,UA;3-β-hydroxy-urs-12-en-28-oic acid)是一种存在於迷迭香中的多酚类化合物,目前已被证实具有抗氧化和抗癌的活性。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。