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From the early study of the pathogenesis of pre-eclampsia people have found its association with immunological function . In 1986 Ellis et al[1] had found that the extravillous chorionic cytotrophoblast contacting with the maternal tissue expressed high levels of Human leukocyte antigen-G, a major histocompatibility tissue-specific antigen . Extravillous chorionic cytotrophoblast with high levels expression of HLA-G proteins can invade the maternal deciduas and the maternal spiral arteries by displacing the endothelial lining and destroying most of the musculoelastic tissue of these arteries .

早期研究开始,许多学者即发现其与免疫学有密切关系,至1986年Ellis等[1]发现人类白细胞抗原(human leukocyte antigen,HLA) G分子高度表达在绒毛外滋养层细胞( extravillous cytotrophoblast,EVCT)上,即浸润至子宫蜕膜层甚至达子宫浅肌层以及子宫螺旋动脉内皮层,与母血及子宫组织直接接触的滋养细胞,这种独特的组织分布提示HLA-G分子在母胎免疫耐受方面起重要作用。

Objective To evaluate the therapeutic effect of naevus fuscocaeruleus zygomaticus treated by using Q-switched Nd:YAG laser associated with recombinant human epidermal growth factor to lessen pigmentation and decurtate course of treatment.

摘要]目的:评价Q开关Nd:YAG激光联合重组人表皮生长因子(recombinant human epidermal growth factor,rhEGF)在治疗颧部褐青色痣(naevus fuscocaeruleus zygomaticus NFZ)过程中对减轻色素沉着,缩短疗程的作用。

objectiveto evaluate the therapeutic effect of naevus fuscocaeruleus zygomaticus treated by using q-switched nd:yag laser associated with recombinant human epidermal growth factor to lessen pigmentation and decurtate course of treatment.

摘要]目的:评价q开关nd:yag激光联合重组人表皮生长因子(recombinant human epidermal growth factor,rhegf)在治疗颧部褐青色痣(naevus fuscocaeruleus zygomaticus nfz)过程中对减轻色素沉着,缩短疗程的作用。

The hNaDCS (human Na+/dicarboxylate cotransporter 3) mediates the transport of Krebs cycle intermediates, such as succinate, citrate and a-ketoglutarate, across the plasma membrane of many epithelial cells.

摘要人钠/二羧酸协同转运蛋白3(human Na~+/dicarboxylate cotransporter3,hNaDC3)基因的编码产物是位于多种上皮细胞膜表面的一类介导琥珀酸、枸橼酸及α-酮戊二酸等三羧酸循环中间产物转运的蛋白。

ABSTRACT Objective: To observe the effect of mixed umbilical cord blood plasma on the culture of human umbilical vein endothelia cells.

摘 要 目的:观察混合脐血浆在人脐静脉内皮细胞(human umbilical vein endothelial cells, HUVEC)培养中的作用。

The therapeutic effect of recombinant vaccinia virus encoding human IL-2 gene(IL-2VV) on the tumor-bearing mice was investigated. The tumor-bearing mice were established by subcutaneus inoculation with 2×106 FBL-3 erythroblastic leukemia cells into C57BL/6 mice.

观察了编码人白细胞介素2(IL-2)基因的重组痘苗病毒(recombinant vaccinia virus encoding human IL-2 gene,IL-2VV)对小鼠接种FBL-3红白血病细胞诱发肿瘤的治疗作用。

The basic principle of the vaccine ' s formulation was designed to use a key pregnant-depentent,transit present,tissue specific and molecular structure well-known glycoprotein hormone—human chorionic gonadotropic hormone through the application of protein engineering techniques,the crossreactivity with three other pituitary glycoprotein hormones and the immunotolerance of the body to this "self" hormone have been overcome and the biological activity of hCG remained intact.

疫苗构建是采用妊娠特异性强、妊娠期短暂出现的糖蛋白激素——人类绒毛膜促性腺激素(human chorionic gonadotropic hormone,hCG)为靶抗原,应用蛋白质工程技术研制的。

Methods The 26th exon, the 30th exon and the 21st intron of gene GP Ⅱb in 110 individuals were amplified by polymorphism and sequenced to investigate whether there was linkage among the polymorphisms of the gene. Human platelet antigen-3 (HPA-3) gene frequency was detected by Fok 1 enzyme in 147 patients with hematologic diseases, and was compared with that in 110 normal individuals. Forty-four patients who received apheresis platelet transfusion repeatedly were randomly divided into the HPA-3 homotype group and the control group. The antibodies of the platelet were detected after 3 times of platelet transfusion.

聚合酶链反应-单链构型多态性分析检测110例正常人GP Ⅱb基因第26和30外显子(Exon 26, Exon 30)及21内含子(Intron21)基因多态性,进行基因序分析,研究这些基因多态性是否存在连锁关系;应用Fok1酶切法对147例血液病人人类血小板抗原-3(human platelet antigen-3, HPA-3)基因进行分型,并与110例正常人进行比较;将接受单采血小板输注的44例血液病人随机分为HPA-3同型输注组和对照组,血小板输注3次以后检则血小板抗体。

AIM: To study the effect of pyrrolidine dithiocarbamate, a potent inhibitor of NF2κB, proliferation and apop- tosis of human pterygium fibroblasts,inculture and search for a new method to prevent the recurrence after pterygium surgery.

目的:研究(nuclear factor,NF)2κB抑制剂吡咯烷二硫氨基甲酸(NF-B Inhibitor pyrrolidine dithiocarbamate,PDTC)对体外培养人翼状胬肉成纤维细胞(human pterygium fibroblast,HPF)增殖的影响,寻找辅助治疗和预防翼状胬肉复发的新方法。

Both active components of plant herbs with an analogical isomeride structure were chosen as research targets. A combination of intrinsic fluorescence, UV-Vis, FTIR and the molecular modeling techniques has been used to characterize the binding between both flavones and human gammaglobulin.

将互为同分异构体的两种植物药活性组分山姜素和豆蔻明作为研究对象,应用荧光光谱法、紫外光谱法以及红外光谱法并结合分子对接技术首次对这两种黄酮类化合物与人-γ球蛋白(Human gammagobulin, HG)的相互作用进行了详细研究。

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