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Human Hp 1-1, cervine Hp, and porcine Hp is homogeneous dimer2, tetramer4, and dimer ????

人类Hp 1-1、鹿Hp以及猪Hp在型态上个别为同质性二聚体????

HP positive groups was compared with HP negative groups in gastric mucosal lesions, expression of P16 in HP positive groups was lower than that in HP negative (P<0.01), expression of CD44V6, PCNA and C-met in HP positive groups were all higher than those in negative groups (P<0.01). Expression of P16 was negative correlated with expression of CD44V6, PCNA and C-met in HP-infected gastric mucosal lesions (r〓=-0.6971, P<0.01; r〓=-0.4811, P<0.01; r〓=-0.6075, P<0.01); Expression of CD44V6 were positive correlated with expression of C-met and PCNA (r〓=0.6550, P<0.01; r〓=0.4977, P<0.01). Selenium level in HP-infected gastric mucosal was Significantly higher than normal and the level will fall with deteriorism of gastric mucosal lesions.

临床标本研究结果表明:在系列胃粘膜病变中,P16表达HP阳性标本显著低于HP阴性标本(P<0.01);CD44V6、C-met、PCNA表达HP阳性标本均显著高于阴性标本(P<0.01);在HP感染的胃粘膜病变组织中,P16表达与CD44V6、C-met、PCNA表达均呈负相关(r〓=-0.697l,P<0.01;r〓=-0.4811,P<0.01;r〓=-0.6075,P<0.01);CD44V6表达与C-met、PCNA表达相互呈正相关(r〓=0.6550,P<0.01;r〓=0.4977,P<0.01);HP感染的胃粘膜病变组织硒含量明显升高,并随胃粘膜病变程度加重相对降低,但高于正常组织;硒含量分别与CD44V6、C-met、PCNA表达阳性率呈负相关(P<0.05),而与P16表达阳性率呈正相关(P<0.05)。

PART ONEInvestigation on Hp CagA+ strain infection condition and pathogenesis risk analyze in patients of carotid atherosclerosisObjective To observate pathological changes of carotid atherosclerosis as well as Hp infection situation, examinate blood fats, blood serum hs-CRP, blood plasma YKL-40, blood serum sCD14, analyze relations between Hp or Hp CagA+ strain and carotid atherosclerosis, and explore possible mechanism of carotid atherosclerosis caused by infection.

然后进行基础动物实验,应用Hp CagA+菌株干预高脂血症大兔,建立Hp CagA+菌株感染致兔颈动脉粥样硬化模型,进行血清Hp抗体、hs-CRP、血浆YKL-40水平检测、斑块内Hp DNA,进一步求证Hp CagA+菌株感染和颈动脉粥样硬化形成的相关性,Hp CagA+菌株感染是否可促进颈动脉粥样硬化的形成,深入探讨其可能机制,以期为颈动脉粥样硬化形成的病因学研究提供实验基础,为临床治疗颈动脉粥样硬化提供新的策略,从而完善其防治模式。

Methods Treatment in Digestion Apartment in our hospital, we will examine the patient using Gastro scope if it has Clinical symptom At the same time, using HP to examine the sample of 316 HP Masculine patient which divided into two groups, gives separately two different plans of the effective three Associations of drugs to eradicate the HP for one week, after four weeks to examine HP aga...

方法顺序随机取本院消化科就诊,有临床症状,行胃镜检查,同时进行Hp检测,将316例Hp阳性患者平分二组,分别给予二种不同方案的正规三联根除Hp治疗1周,四周后复查Hp阴性者为根除,阳性者仍为感染。

This paper mainly deals with these two parts:l.the effect of hydrosoluble HP,fibermesh and FDN on cement mortars bend resistant strength and compressive strength under the same operating conditions and with different HP mixtures;2.the effect of HP,FDN moderator,fly ash on the durability of concrete.that is the performance of resisting osmose,erosion and freeze thawing.

研究了HP水溶性高分子"纤维"、FDN高效减水剂与粉煤灰双掺配制的高性能混凝土的耐久性(抗渗透、抗硫酸盐侵蚀、抗冻融性能)。试验结果表明:HP水溶性高分子"纤维"对水泥砂浆和混凝土具有显著的增韧、增强作用,且水泥砂浆的抗压强度随着HP水溶性高分子"纤维"掺量的增加(2%-6%)而提高,抗折强度则降低;在混凝土中加入HP水溶性高分子"纤维"后,抗压强度随着掺量的增加2。

Objective To explore the clinical value of the titer of serum HP antibody in patients with gastric diseases.Methods Serous HP antibody was detected with ELISA and HP was cultured,tested with urase,and stained with Gram method on smears which was observed microscopically and compared with proteus protein-enveloped test.Results ELISA showed high sensitivity and specificity.Conclusion Serous ELISA detection of HP antibody can be used widely in clinical diagnosis and epidemical screening without endoscopy and biopsy.

目的 探索胃部疾病患者血清中的幽门螺旋菌HP抗体滴度的临床价值方法应用酶联免疫吸附试验ELISA法检测HP抗体与HP培养,尿素酶试验和涂片革兰氏染色作镜下形态检查相比较,并同时与变形杆菌蛋白包被测定法作比较结果显示该法具有敏感特异性强的特点结论该法无需常规内镜检查,活检查HP而单纯用血清学检查,可广泛应用于临床诊断和流行病学人群普查

In order to make the area infected by Hp visible under endoscope, the authors spray bromocresol purple—urea fluid onto gastric antrum mucosa to show color, and then to define whether or where it is infected by Hp because the area infected by Hp will become purple color.

做法是在内镜下经活检孔道将Hp识别液5~10ml喷洒在球部、胃窦幽门区,有糜烂、充血、溃疡、疣状凹陷等病变处,1~2分钟后上述各部如呈紫色即示Hp存在。结果本组阳性者128例,阳性率50.0%。在阳性着色区做粘膜活检,做涂片和石蜡切片用作者研制的乙醇中性红染色,结果100%检出Hp。

Methods:~(13)C-urea respiratory test and detection of Helicobacter pylori antigen in stool samples were used to evaluate the infection of helicobacter pylori between 62 cases of psoriasis and 35 healthy cases of control. The 62 cases of psoriasis were regrouped to observe group in which 32 psoriasis cases were infected with HP and control group in which 30 psoriasis cases were not infected. Anti-helicobacter pylori therapy and tretinoin were used to observe group. Control group was treated only with tretinoin. Therapeutic effective rate and PASI were observed.

62例寻常型银屑病患者与35例健康体检者对照,用尿素~(13)C呼气试验及幽门螺杆菌粪便抗原检测HP感染情况,比较两组结果;62例银屑病患者根据HP感染情况再次分组,32例HP阳性者为治疗组,30例HP阴性者为对照组,治疗组给予抗HP三联治疗及外用维甲酸软膏,对照组仅外用维甲酸软膏,观察PASI评分及治疗总有效率。

Methods Hp was detected in 152 cases with perioral dermatitis,and then the Hp-positive patients were divided into two groups,the efficacy of Hp eradication therapy was studied.

对152例口周皮炎患者进行Hp检测,合并Hp感染者分为两组治疗,观察Hp根治对口周皮炎的影响。

For the cases of CHD,the level of plasma endothelin-1 in these of HPIgG seropositivity is higher than that of HP seronegativity(P.05).(4) No correlation between chronic HP infection and essential hypertension,diabetes mellitus,tobacco use,age,gender,vocation,living condition ,alcohol consumption and family history was found.(5) For the cases of positive for Carbon-14 urea breath test in CHD patients, the level of plasma GLU is higher than that of negativity for Carbon-14 urea breath test (P.05).The rate of positive for Carbon-14 urea breath test in CHD patients with diabetes mellitus is significantly higher than that of CHD patients without diabetes mellitus.

结果(1)冠心病组血清HPIgG阳性率明显高于非冠心病组(45.54%vs 28.30%,P<0.05);(2)冠心病组C-14呼气试验阳性率明显高于非冠心病组(54.46%vs 30.19%,P<0.01);(3)冠心病组慢性HP感染者血浆ET-1水平明显高于非HP感染者(P<0.05);(4)慢性HP感染与血脂、高血压史、糖尿病史、吸烟史、年龄、性别、职业、生活环境、饮酒史以及冠心病家族史无关;(5)现症HP感染与糖尿病及空腹血糖升高有关(P<0.05);与血脂、高血压史、吸烟史、年龄、性别、职业、生活环境、饮酒史以及冠心病家族史无关。

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