查询词典 hippocampus

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

The epilepsy model induced by kainic acid is a dynamical model condition. 5-7 days after acute seizure episodes induced by a single systemic injection of a convulsant dose (10mg/kg) of KA the rats developed a long-lasting increase in seizure susceptibility and the characteristic histopathological features in the hippocampus similar to human TLE. So the KA model has been a well-known model to study TLE or intractable epilepsy.

颞叶癫癎红藻氨酸（kainic acid，KA）模型具有明确的动态变化过程，一次全身性给予惊厥剂量（10mg/kg）KA诱发SD大鼠急性癫癎发作后5-7天，动物开始出现癫癎发作敏感性长期增强，脑内亦发生与人类颞叶癫癎相似的神经病理、神经生化及神经分子生物学方面的改变，因此被认为是研究颞叶癫癎和难治性癫癎的理想模型之一。

Objective: To observe the change of JNK in the hippocampus of status convulsive rat and the regulation effect of EDA on it.

目的：研究在惊厥持续状态幼年大鼠海马中的表达及依达拉奉对其的影响。

DGCs in girdin-deficient neonatal mice exhibit deficits in axonal sprouting in the cornu ammonis 3 region of the hippocampus.

对新生小鼠齿状回缺失Girdin蛋白的细胞的研究表明，小鼠神经细胞不能形成轴突。

Most significantly of all, it shrinks the volume of the prefrontal cortex and the hippocampus.

最为明显的是，它缩小了前额叶皮质和海马体的体积。

Elevation of corticosterone has been associated with a drop in the production of new stem cells in the hippocampus.

标高的皮质都伴随着下降，生产新的干细胞在海马状突起。

Based on the four-vessel occlusion models, neuron apoptosis in CA1 region of hippocampus was detected by cresyl violet staining, the phosphorylation of JNK and Bad (ser128) were detected by immunoblot...

以大鼠四动脉结扎脑缺血模型为基础，应用焦油紫染色法检测海马CA1区神经元凋亡，采用免疫印迹检测JNK和Bad(ser128)的磷酸化。

Learning and memory performance of rats was measured by using Morris water maze first and Y-maze afterwards. Neurons in the dentate gyrus, CA3 and CA1 regions of the hippocampus were stained by using Cresyl violet method and counted.

采用Morris 水迷宫和Y-迷宫测试大鼠学习与记忆成绩，并用Cresyl violet染色法对大鼠海马结构进行神经细胞计数。

Basing on the four-vessel occlusion models,neuron apoptosis in CA1 region of hippocampus was detected by cresyl violet staining,the phosphorylation of Akt and Bad(ser136)were detected by immunoblotting.

以大鼠四肢动脉结扎脑缺血模型为基础，应用焦油紫染色法检测海马CA1区神经元凋亡，采用免疫印迹检测Akt和Bad(ser136)的磷酸化。

Methods Transient (15min) brain ischemia was induced by the four-vessel occlusion in Sprague Dawleyrats. The antisense oligodeoxynucleotides of Src and Fyn were used to suppress the expression of Src and Fyn by intracerebroventricular infusion once per day for 3 days before ischemia. After 5 days reperfusion, rats were perfusion-fixed with paraformaldehyde and cresyl violet staining were used to examine the survival of CA1 pyramidal cells of hippocampus.

采用Pulsinelli-Brierley 4动脉阻塞(4-VO)大鼠全脑缺血模型，缺血前连续3d脑室注射Src、Fyn反义寡核苷酸(antisense oligodeoxy-nucletides， AS ODNs)抑制Src、Fyn蛋白的表达后缺血，复灌5d，石蜡切片，焦油紫染色，图像分析测定单位面积内焦油紫染色细胞面积总和，与缺血组及错义寡核苷酸组(missense oligodeoxy-nucletides， MS ODNs)比较进行形态学分析。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。