查询词典 hematopoietic

Adult mesenchymal stem cells are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin.

成人间质干细胞是一种具有分多谱系化能力，能分化成中胚层来源的各种组织的非造血细胞。

Methods We used Amphotericin B for fungous septicemia complicated with allo-geneic hematopoietic stem cell transplantation (2 cases of server aplastic anemia, 1 case of acute lymphoblastic leukemia) or chemotherapy (2 cases of chronic lymphoblastic leukemia,5 cases of acute monoblastic leukemia). The long-term of one to three months Amphotericin B was used at total dose range from 1750 to 3115 microgram with drug prophylaxis and care.

对异基因造血干细胞移植3例（SAA 2例、ALL 1 例）和白血病化疗后7例（CLL 2例、M55例），出现真菌性败血症时应用长程（1～3个月）的两性霉素B治疗，总剂量为1750～3115 mg，观察其疗效和并发症，且对并发症采用药物预防和护理。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

BACKGROUND: Allogeneic hematopoietic stem cell transplantation is recognized as the only method of curing chronic myelocytic leukemia.

背景：异基因造血干细胞移植是目前公认的惟一可以治愈慢性粒细胞白血病的方法，但存在供体来源少，移植相关并发症较多等问题。

Acute myelocytic leukemia is a malignant neoplasm of hematopoietic cells characterized is an abnormal proliferation of myeloid precursor cells.

急性前骨髓性白血病，是一种造血组织的恶性疾病，其治病原因乃骨髓性前趋细胞不正常的大量增生，并有细胞分化停止的病变。

Conclusions-: In adult density-gradient separated BMMNCs, canonical Wnt3a promotes stemness, proliferation, and hematopoietic commitment, whereas noncanonical signaling via Wnt11 induces robust cardiomyogenic differentiation in a protein kinase C- and c-Jun-N-terminal kinase-dependent manner.

结论- ：在成人密度梯度分离BMMNCs，典型wnt3a促进stemness 增加及造血，而非典型信号通过wnt11强有力的诱导C-蛋白激酶和c-Jun-N -氨基末端激酶依靠性的心肌细胞分化。

Hematopoietic stem cells are being increasingly for treatment of malignant and nonmalignant disorders.

造血干细胞在许多危重疾病的治疗中有重要作用。

The therapeutic effect of the therapies were evaluated according to the relief of ostalgia and quality-of life, local bone metabolism and hematopoietic function of the bone marrow.

结果 治疗组与对照组止痛有效率分别为94.0%和76.0%P.05；生存质量的提高稳定率分别为94.0%和74.0%(P.05；治疗后两组间转移病灶骨代谢情况及血液毒性反应均具有显著差异(P.05， P.01)。

Recent progress has been made in the identification of the osteoblastic cellular niche for hematopoietic stem cells within the bone marrow.

最近在识别骨髓中造血干细胞的成骨细胞龛方面方面取得了新的进展。

Purpose To study the protective effects of polysaccharides from lichen of parmelia tinctorium on hematopoietic function and DNA repair in radiation-injured mice.

目的研究地衣类石花多糖对辐射损伤小鼠造血功能及DNA损伤的防护作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。