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The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

I promise , having the gift of the gab in the past but can't vomit any wording , I turn round, leave, there are the tears Sorry mother How of no use I am, will only let you worry about Remember you help me to think of the mathematics question at night, that is that I have already slept Remembering father that you look after the drinks are a wild boast, that is that you are very tired out Remember that you wash the bowl and wash the clothes and sweep the hygiene , you have neither enmity nor repentance You get up early more than I, sleep later than I, but let me sleep carefully You live frugally by oneself, but satisfy all of my ones that want I really ache very much Cardialgia Let me see to cry Want to wail heartily In the face of the blow coming head-on again and again I have already forgotten how to smile to face Please don't let me put on an air of cheerfulness Give me the time that a little agony suffocate I am too tired ------------------------- Pretend to be strong, the heart is disguised by the smile, hides fragily in the bed clothes, the tears are released , soak all, one touches the broken one sad Fools are all the same, not knowing how to escape being sad , because always there is a dream on the body

我一声答应，往日里的伶牙俐齿却吐不出任何字眼，我转身，走，泪已满面对不起啊妈妈我怎么那么没用，只会让你操心的记得你深夜帮我想数学题，那是我已沉睡记得你照顾喝的天花乱坠的爸爸，那是你很疲惫记得你洗碗洗衣服打扫卫生，你无怨无悔你比我早起，比我迟睡，却让我好好睡你自己省吃俭用，却满足我所有想要的我真的很痛心痛我想哭想放声大哭面对一次又一次迎面而来的打击我已经忘记了如何笑着面对请不要让我强颜欢笑给我一点痛苦窒息的时间我太累了-------------------------假装坚强，心被笑容伪装，脆弱在被褥里匿藏，泪释放，浸湿所有，一碰就破的悲伤傻瓜都一样，都不懂得逃避悲伤，因为总有梦想在身上谢谢了，如果翻译的好分我可以多加问题补充：在那个"想放声大哭"和"面对一次又一次迎面而来的打击"之间加一句："我真的已经尽了最大努力，可为什么还是做不到？！"

It is this year above A5 see have a lot of people saying about cleaning out the station of customer respect, I looked to mug-up is moved at that time, act immediately then, there also is domain name of a few rubbishes on the hand, did not make a station, want to be done this then and clean out the domain name related treasure to try, checked a few to be registered, final make choice of the theme that cleans out treasure female outfit to do a website, checked in Baidu index, though clean out the index that treasure daughter holds to have 100 many a little bit only, but check the net that clean out treasure,index of female outfit Baidu has 3000 much, have the tendency that rise, I do the content that cleans out treasure daughter to hold a respect with respect to the decision, very successful enrollment domain name, chose the pattern plate that DEDE5.3 acquiesces with the government, informal modification below, the line on another my new website, looked for relevant content handiwork to add his on the net that clean out treasure again above the website, used time of a week probably so, how was website domain name also publicized.

今年在A5上面见有很多人在说关于淘客方面的站，当时我看了有点心动，于是就马上行动，手上也有几个垃圾域名，没有做站，于是想这次搞个和淘宝相关的域名试试，查了几个都被注册了，最后选定了淘宝女装来做网站的主题，在百度指数里查了下，虽说淘宝女装的指数只有100多点，可是一查淘宝网女装百度指数有3000多，并有上升的趋势，我就决定做淘宝女装方面的内容，很顺利的注册了域名，并选用了DEDE5.3用官方默认的模板，随便的修改了下，我又一个新的网站上线了，再在淘宝网上找了相关的内容手工添加到自己网站上面，这样大概用了一星期的时间吧，网站域名也没怎么宣传。

Most of these managers have no need to work for a living; they show up at the ballpark because they like to hit home runs. And that's exactly what they do. Their combined financial statements (including those of some smaller operations), shown on page 49, illustrate just how outstanding their performance is. On an historical accounting basis, after-tax earnings of these operations were 57% on average equity capital. Moreover, this return was achieved with no net leverage: Cash equivalents have matched funded debt. When I call off the names of our managers - the Blumkin, Friedman and Heldman families, Chuck Huggins, Stan Lipsey, and Ralph Schey - I feel the same glow that Miller Huggins must have experienced when he announced the lineup of his 1927 New York Yankees. Let's take a look, business by business: o In its first year with Berkshire, Borsheim's met all expectations. Sales rose significantly and are now considerably better than twice what they were four years ago when the company moved to its present location.

大部分的管理人根本就不需要为了讨生活而工作，他们参加球队的原因只是为了要击出全垒打，事实上这正是他们常常有的表现，他们合并的财务报表，显示他们的表现是如此的优异，以历史投资成本做基准，他们现在每年的税后盈余高达平均股东权益的 57%，更甚者，他们并不靠举债，帐上所拥有的现金就足以清偿所有的借款，当我念到这些管理人的名字- the Blumkin， Friedman， Heldman families， Chuck Huggins， Stan Lipsey 与 Ralph Schey ，这感觉就好象是名教练 Miller Huggins 在宣布 1927 纽约洋基队的先发阵容一样。

To pay attention, some girls buy the foreign trade clothes clothes, clothes look like fundamentally do not have the problem, but puts on the upper body to be able to discover, two side shoulders not equally high, sleeve not equally uneven, chest too width very sloppy, either Sleeve puts on for a morning to be able upwardly to hemstitch, these goods also all are the slight defect, this kind cannot see the slight defect at least needs to put on for several hours only then to be able to discover, but very many girls on-line buy clothes, either trial time too happy, only turns and look at the design and the color, looks for the end of a thread, either is busy is chopping the price, how doesn't have pays attention, And so on went home has put on a day discovery problem, also has been late, therefore everybody bought clothes time wanted careful to try oh!!

如了解该资讯相关课程或报读，请联系我们的课程顾问或网上留言◆如需要报读或了解更多的资讯，请点击"深圳专业英语培训网"关于选购衣服注意的是，有的女孩买外贸衣衣，衣服看起来根本没毛病，可是穿上身就会发现，两边肩不一样高，袖子不一样齐，胸口太宽很邋遢，或者衣摆穿一上午就会向上卷边，这些货也全都是瑕疵品，这种看不出的瑕疵至少要穿几个小时才会发现，但是很多女孩在网上买衣服呀，或者试的时候太高兴，只顾看款式和颜色，找找线头啦，或者忙着砍价，就没怎么注意，等回家穿了一天发现毛病，也晚了，所以大家买衣服的时候要仔细一点的试哦！！

On such day: there develops, occurs, exists or comes into force any event whereby in the reasonable opinion of the Underwriter, the success of the Open Offer or the business or financial condition and/or prospects of the group would, might be or is likely to be adversely affected or which makes it inadvisable or inexpedient to proceed with the Open Offer; or there comes to the notice of the Underwriter or the Underwriter shall have reasonable cause to believe that any of the undertakings or other obligations expressed to be assumed by or imposed on the Company under the underwriting agreement have not been complied with in any material respect; or there comes to the notice of the Underwriter or the Underwriter shall have reasonable cause to believe that any of the representations or warranties given by the Company under the underwriting agreement was untrue, incorrect, misleading or inaccurate in any material respect which adversely affect the success of the Open Offer; which in the reasonable opinion of the Underwriter: is or may or will be or is likely to be adverse to, or prejudicially affects, the business or financial or trading position or prospects of the group taken as a whole; or is or may or will be or is likely to adversely affect the success of the Open Offer and/or makes it impracticable, inexpedient or inadvisable for any part of the underwriting agreement and the Open Offer to be performed or implemented as envisaged; or make or will or is likely to make it impracticable, inexpedient or inadvisable to proceed with the Open Offer or the delivery of the convertible non-voting preference shares on the terms and in the manner contemplated by the Prospectus or the underwriting agreement.

Samson Paper Holdings Limited Provisional Allotment Account 倘于接纳可兑换无投票权优先股份及付款的截止时间后两个营业日下午六时正前任何时间出现下列事件，则公开发售包销商Quinselle Holdings Limited可于该日期下午六时正前任何时间向本公司发出书面通知以终止包销协议：因任何事件之出现、发生、存在或生效而令包销商合理认为将会、可能或极大机会对公开发售能否顺利进行或本集团之业务或财政状况及╱或前景构成不利影响，或致使进行公开发售实属不合理或不合宜；或包销商注意到或包销商有合理理由相信本公司并无于所有重大方面遵守根据包销协议列明须承担或获委予之任何承诺或其他责任；或包销商注意到或包销商有合理理由相信本公司根据包销协议作出之任何陈述或保证于任何重大方面属失实、错误、误导或不准确而对公开发售能否顺利进行造成不利影响；而包销商合理认为：经已或可能或将会或大有可能对本集团整体业务或财政或经营状况或前景造成不利影响或损害；或经已或可能或将会或大有可能对公开发售能否顺利进行构成不利影响及╱或使持续进行使包销协议的任何部份或公开发售的进行或落实为不实际、不合适或不合宜；或按发售章程或包销协议拟订之条款及方式持续进行公开发售或寄发可兑换无投票权优先股份导致、将为或大有可能为不实际、不合适或不合宜。

This ain't a love song 歌手:bon jovi this ain't a love song bon jovi i should have seen it coming when roses died should have seen the end of summer in your eyes i should have listened when you said good night you really meant good bye baby, ain't it funny, how you never ever learn to fall you're really on your knees, when you think you're standing tall but only fools are "know-it-alls" and i played that fool for you i cried and i cried there were nights that died for you baby i tried and i tried to deny that your love drove me crazy, baby if the love that i got for you is gone if the river i cried ain't that long then i'm wrong, yeah i'm wrong, this ain't a love song baby, i thought you and me would stand the test of time like we got away with the perfect crime but we were just a legend in my mind i guess that i was blind remember those nights dancing at the masquerade the clowns wore smiles that wouldn't fade you and i were the renegades, some things never change it made me so mad 'cause i wanted it bad for us baby now it's so sad that whatever we had, ain't worth saving if the love that i got for you is gone if the river i've cried ain't that long then i'm wrong, yes i'm wrong, this ain't a love song if the pain that i'm feeling so strong is the reason that i'm holding on then i'm wrong, yeah i'm wrong - this ain't a love song i cried and i cried there were nights that i died for you baby i tried and i tried to deny that your love drove me crazy baby if the love that i got for you is gone if the river i cried ain't that long then i'm wrong, yeah i'm wrong - this ain't no love song if the pain that i'm feeling so strong is the reason that i'm holding on then i'm wrong, yeah i'm wrong - this ain't a love song by lune the end JTL 很长时间Love Is A Pain (I don't cry)(I don't cry)(I don't cry)(I don't say) As time gose by

你身边的那个人看起来会比我做得更好放你离开的那个冬天，痛苦了好久，但是都没有用了开始我小心地走向你，你用阳光般的微笑接受了我的心那么想见你，落下了泪，但是（I don't cry）现在什么也无法说想说爱你，现在不再是我的你有的时候给我的问候的电话我说现在过得很好这样的话，但舌头无法像以前看到了我变瘦的样子，你也会吃惊放你离开的那个冬天，痛苦了好久，但是都没有用了开始我小心地走向你，你用阳光般的微笑接受了我的心那么想见你，落下了泪，但是（I don't cry）现在什么也无法说想说爱你，但现在不再是我的你如果对我说你回来吧我会再次抱着你如果只想看我一次，我会把空位子留给你说不定那个时候是我们两个再一次没有办法地擦肩而过的命运我这样疼痛，你也会非常疼痛的，那个时候你也说没有办法我的没有用的自尊心非常非常的后悔没有你，度过了很长时间，只一个人没有你，我忍受着，得生活下去，我没有自信那么想见你，落下了泪，但是（I don't cry）现在什么也无法说想说爱你，我想再见到你，但现在好象一切都结束了希望好久以来积攒的记忆，到什么时候都不会在时间里被埋没祝你幸福

Nanomaterials have many new characterizes which different from the normal materials for their small size, big surface area ratio and quanta dimension domino effect, for examples, the metal with good conductor will be turned into nonmetal when the size is reduced tonanometer levels; the resistance of originally nonconductor will be descended greatly when its size is reduced several nanometers or so, and loss the nonconductor property; the general solid is steady under certain conditions, while under nanometer conditions, the capabilities will be effected greatly by the granule sizes, the newness characteristics made nanomaterials have great appliance foreground on catalyze, optics, and industry produce and so on, therefore the nanomaterials have been the hotspot for materials science, chemistry science and so on.

纳米材料由于尺寸小、比表面积大和量子尺寸效应使它具有不同于常规固体材料的新的特征，如原来是良导体的金属，当尺寸减小到纳米量级时就变成非金属型；原来是绝缘体的物质，当尺寸减小到几纳米或几十纳米时电阻大大下降，失去了绝缘体特性；常规固体在一定条件下物理性能是稳定的，在纳米状态下，颗粒尺寸对性能产生强烈的影响等等，这些新奇的特点使得纳米材料在催化、光学、工业生产等各个方面都有着广阔的应用前景，因此，纳米材料目前已经成为材料科学、物理学及化学等学科的前沿热点。1990年7月在美国巴尔基摩召开了国际第一届纳米科学技术会议，正式把纳米材料科学作为材料科学的一个新的分支公布于世。

Pass observation of clinical curative effect, cure can enhance Chinese traditional medicine fitness, improve immune function, control allergic source, the upper respiratory tract relapses the symptom such as infection, have main effect to reducing blood in the urine, albuminuria, draft the root of remembranous milk vetch, Asian puccoon oneself, yuan grass of armour of ginseng, madder, 37 ginseng, plain hill, horsewhip, Bai Maogen, n/bot glossy privet child group waiting for medicine square, heat up detoxify with Yu Qing, invigorate the circulation of blood whitewashs Yu, cool blood filling kidney of hemostatic, method of treating yin deficiency by reinforcing body fluid and nourishing the blood administer a law, achieve the goal that administer thoroughly. 1 data and method 1 · 1 clinical data: 186 patients all are outpatient service case of illness, accord with Minica to concern the diagnostic standard of purpuric sex nephritis, among them the male 105, female 81, come on on average age 8~13 year old, time sees a doctor after coming on 3 months ~1 year, have direct allergen 86, have apparent infection 20, the others cause of disease is same.

通过临床疗效观察，中药治疗能增强身体素质，提高免疫功能，控制过敏源，上呼吸道反复感染等症状，对减少血尿、蛋白尿起到主要功能，自拟黄芪、紫草、元参、茜草、三七参、川山甲、马鞭草、白毛根、女贞子等药组方，用于清热解毒，活血化瘀、凉血止血、滋阴补肾等治法，达到标本兼治的目的。1资料和方法1·1临床资料：186例患者均为门诊病例，符合Minica有关紫癜性肾炎的诊断标准，其中男性105例，女性81例，平均发病年龄8~13岁，发病后就诊时间3个月~1年，有直接过敏原86例，有明显感染20例，其余病因相同。

This project was established based on the first cooperative development of optical in situ real time detecting technique probing the atomic scale layer-by-layer epitaxy growth of oxide film. Over the last three years, we have given full play to the advantages and characteristics of both sides and have finished the assumptions and plans of this subject satisfactorily. 1. In Institute of Physics, we set up advanced oblique-incidence reflectivity difference equipment and wrote one data acquisition procedure that made the simultaneous detection of optical signal and RHEED signal into reality. 2. The first observation of sustained oscillations over hundreds of monolayers in both real and imaginary signals during the epitaxy growth of SrNb0.1Ti0.9O3 on SrTiO3 substrate in LMBE testifies that oblique-incidence is an excellent method to detect and monitor film epitaxy growth real time. 3. For the first time, we verify that oblique-incidence reflectivity difference method can be used to monitor the layer-by-layer growth mode during continuous growth through the correspondence between optical signals to atomic or molecular step edge density on the growth surface. 4. Phenomenological analysis shows that optical signals comprise three parts, the first is proportional to the average thickness of the film and depends on the bulk phase dielectric response; the second is proportional to the coverage of terraces and depends on the dielectric response of atoms or unit cells in the terrace; the third is proportional to the coverage of step edges and depends on the effective dielectric response of atoms or unit cells at step edges. This makes oblique-incident reflectivity difference technique a quantitative macroscopic method to monitor film growth.

中文摘要：本课题是在合作首次发展了氧化物薄膜原子尺度层状外延生长光学原位实时探测方法的基础上立项的，三年来，我们充分发挥双方的优势和特点，圆满完成了课题的设想和计划。1、在物理所建立了一套先进的光反射差法装置，编写了计算机系统的数据采集程序，实现了两路光学信号和RHEED数据的同步采集和显示。2、用激光分子束外延在SrTiO3基底上生长SrNb0.1Ti0.9O3薄膜，首次观测到连续外延几百个原胞层，周期振荡的光反射差实部和虚部信号，证明了光反射差法是一种能原位实时探测与监控薄膜层状外延生长的好方法。3、首次验证了通过对生长表面原子或分子台阶密度的响应，光反射差法可用于原位实时监测在连续生长条件下薄膜的层式生长模式。4、通过唯象理论的研究，证明光反射差信号由三项组成，第一项只与薄膜的平均厚度和宏观光学电介质常数有关；第二项与分子台阶面覆盖度和台阶面上分子层的光学电介质常数有关；第三项与台阶边缘的覆盖度成正比，并和在台阶边缘的分子的有效光学介电常数有关。

The objective is to subjugate and discourage the people, because that allows the elite to continue to rule unopposed.

其目的是压制和打击人民的积极性，因为这可以让实权派继续统治不会沦为反对派。

GOD,this is the second time you vanquished me!

天啊，这是第二次你打败了我！