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The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

Color should have matched, color of graph bell advertising perhaps follows mass-tone attune to be close friends consistently, perhaps follow mass-tone phase modulation to be close friends instead, try more, may increase many income, the flower changes a code a few minutes to be able to raise a few yuan of money, the input casing of functional code should have a difference with the color all round, want to have window, for instance all round it is grey black, functional code inputs casing to do a bright yellow, compare so conspicuous.

颜色要搭配好，图铃广告的颜色也许跟主色调一致要好，也许跟主色调相反要好，多尝试一下，也许能提高不少收入呢，花几分钟换个代码就能提高几十元钱，功能代码的输入框要跟四周的颜色有差别，要有亮点，比如四周都是灰黑色，功能代码输入框弄个亮黄色的，这样就比较显眼。

Ladies up Up in here tonight No fighting, no fighting We got the refugees up in here No fighting, no fighting Shakira, Shakira I never really knew that she could dance like this She makes a man wants to speak Spanish Como se llama, bonita, mi casa, su casa Shakira, Shakira Oh baby when you talk like that You make a woman go mad So be wise and keep on Reading the signs of my body And I'm on tonight You know my hips don't lie And I'm starting to feel it's right All the attraction, the tension Don't you see baby, this is perfection Hey Girl, I can see your body moving And it's driving me crazy And I didn't have the slightest idea Until I saw you dancing And when you walk up on the dance floor Nobody cannot ignore the way you move your body, girl And everything so unexpected - the way you right and left it So you can keep on taking it I never really knew that she could dance like this She makes a man want to speak Spanish Como se llama, bonita, mi casa, su casa Shakira, Shakira Oh baby when you talk like that You make a woman go mad So be wise and keep on Reading the signs of my body And I'm on tonight You know my hips don't lie And I am starting to feel you boy Come on lets go, real slow Don't you see baby asi es perfecto Oh I know I am on tonight my hips don't lie And I am starting to feel it's right All the attraction, the tension Don't you see baby, this is perfection Shakira, Shakira Oh boy, I can see your body moving Half animal, half man I don't, don't really know what I'm doing But you seem to have a plan My will and self restraint Have come to fail now, fail now See, I am doing what I can, but I can't so you know That's a bit too hard to explain Baila en la calle de noche Baila en la calle de día Baila en la calle de noche Baila en la calle de día I never really knew that she could dance like this She makes a man want to speak Spanish Como se llama, bonita, mi casa, su casa Shakira, Shakira Oh baby when you talk like that You know you got me hypnotized So be wise and keep on Reading the signs of my body Senorita, feel the conga, let me see you move like you come from Colombia Mira en Barranquilla se baila así, say it!

不会说谎女士们今夜在这里舞动起来没有是非没有争斗我们在这里舞动起来没有是非没有争斗我从未意识她能如此欢快的跳舞人们纷纷说起西班牙语你的名字是？美丽的我的家他的家哦宝贝当你这样说话的时候人们为你如此着迷所以用你的智慧继续细读我的舞蹈于是今夜我欢快的跳舞你知道我的舞蹈不会说谎于是我开始感觉到这一刻所有的吸引所有的不安你看见了吗这便是完美嗨女孩我能看见你舞动的身影于是我着迷于是我迷失直到看见你在跳舞当你舞动的脚步划过地面所有人都为你而注目女孩让人意想不到-忽左而忽右所以请继续跳吧我从未意识她能如此欢快的跳舞人们纷纷说起西班牙语你的名字是？美丽的我的家他的家哦宝贝当你这样说话的时候人们为你如此着迷所以用你的智慧继续细读我的舞蹈于是今夜我欢快的跳舞你知道我的舞蹈不会说谎于是我开始感觉到你的存在来吧让我们一起慢慢的舞动你看见了吗这便是完美哦我知道今夜我正欢快的跳舞我的舞蹈不会说谎于是我开始感觉到这一刻所有的吸引所有的不安你看见了吗这便是完美哦男孩我能看见你舞动的身影如梦如幻我不确定自己在做什么但是你却不同我的意志我的约束现在开始失去开始失去看我正做我能做的但却无法做到你知道这似乎太难解释他在夜晚的街道上跳舞他在白天的街道上跳舞他在夜晚的街道上跳舞他在白天的街道上跳舞我从未意识她能如此欢快的跳舞人们纷纷说起西班牙语你的名字是？

Hi everybody,my name is XX ,i am a student who major in ocean shipping tally,i am so glad to attend the interview.my character is outgoing .it is easy for me to communicate with people.i was the minister of the sports department on school days.so i have some organizational ability and leadship.in my spare time,i have a lot of hobbies,my favorite is enjoying music ,playing basketball and so on.i am now doing my custom entry practice at a small logistics company ,i have got some and working experience to the career of .i attain preparatory realization of XX corporation by internet.it was set up in XX,it is the first ship-owning company of XX.i am look forwad to be a declarant of your firm.please give me a chance,i will not make you disappointed.

各位领导你们好，我叫XX是本院外轮理货专业的学生。很高兴能够参加这次面试。我性格开朗，善于与人交流。在校期间曾担任体育部部长，有一定的组织领导能力。我课余爱好广泛，喜爱听音乐、打篮球、等各项体育活动。最近这一段时间，我在一家小的物流公司实习，从事报关工作，对报关员这一职业用了初步的了解和工作经验。对于XX公司我也通过网络有了初步了解。它始建于XX年，是XX的第一家船公司。我非常想成为贵公司的一名理货员。希望各位领导能够给我一个机会，我不会让你们失望的。ok that's all。问题补充：我叫XX是本院外轮理货专业的学生改成我叫XX 我学习的是外轮理货专业 ocean shipping tallying 外轮理货不要翻译软件谢谢

John and Josie's only child [00:28.23]young and handsome, fast and wild [00:33.58]join in the army at 18 [00:38.74]left the army at 18 [00:44.46]drift then from job to job [00:49.81]town to town and love to love [00:55.17]7 years forever, till young Jonnie came marching home [01:05.85]but Jonnie wasn't looking well [01:10.63]went into the hospital [01:16.41]days turned into several weeks [01:21.73]Jonnie kept on losing weight [01:27.10]Josie said that John sit down [01:32.64]John cried oh god,not my son [01:37.77]Jonnie left at 25 [01:42.39]hole as big as Jupiter [01:49.25] [01:50.10]there's nothing stronger than a love [01:55.21]John and Josie head for Jonnie [02:00.60]throughing his last birthday party [02:06.10]no one from the family came [02:10.04] [02:11.27]no one from the family came [02:16.42]turns John and Josie's grift to shame [02:21.58]shame to anger,anger pain [02:27.05]nothing they needed more now [02:30.28] [02:53.50]2 years's gone, [02:55.38]the telephone is ringing in the dim the damn [03:04.07]beneath the world and cluser face [03:08.93]but John had punched the day he learned [03:14.49]that Jonnie he wouldn't live much longer [03:20.06]now a voice said to his father [03:24.74]Jonnie have a baby here [03:30.11]no one seems to want him [03:33.90] [03:35.94]baby doesn't have his parents [03:40.49]2 months old and with a pair of eyeless [03:46.65]Josie grabbed the phone from John [03:51.79]two of them said yes yes yes [03:57.51]so John and Josie over 60 [04:02.52]taking in a brand-new baby [04:07.78]named Paul Antonio [04:13.29]Jonnie would've loved him [04:18.24] [04:18.99]nothing stronger than a love [04:23.90]John and Josie head for Jonnie [04:29.32]the same love at they've fall apart [04:34.59]they starting up to win again [04:39.71]and on the fear that same could happen [04:45.27]losing paul before his time comes [04:50.53]John and Josie looked right past it [04:55.51]they're basketing in love's mighty presents [05:01.34]John and Josie don't have time [05:07.98]they're basket in love's mighty presents

约翰和Josie歌词翻译悬赏分：5 -离问题结束还有13天22小时 [00 ：23.00]约翰和Josie的独生子 [00 ：28.23]年轻和英俊，快速和狂放 [00 ：33.58]加入军队在18 [00 ：38.74]被留下军队在18 [00 ：44.46]漂泊然后从工作对工作 [00 ：49.81]镇对镇和爱到爱 [00 ：永远55.17] 7年，年轻Jonnie来了前进在家 [01 ：05.85]，而是Jonnie没有很好看 [01 ：10.63]进入医院 [01 ：16.41]天把变成几个星期 [01 ：21.73] Jonnie在丢失的重量保持了 [01 ：27.10] Josie说约翰坐下 [01 ：32.64]约翰哭泣oh神，没有我的儿子 [01 ：37.77] Jonnie离开在25 [01 ：42.39]孔一样大象木星 [01 ：49.25] [01 ：50.10]那里比爱是没什么强 [01 ：55.21]约翰和Josie头为Jonnie [02 ：throughing他的前次生日聚会的00.60] [02 ：06.10]没人从家庭来了 [02 ：10.04] [02 ：11.27]没人从家庭来了 [02 ：16.42]转动约翰和Josie的grift到羞辱 [02 ：21.58]羞辱愤怒，激怒痛苦 [02 ：27.05]他们现在需要的没什么 [02 ：30.28] [02 ：去的53.50] 2年的， [02 ：55.38]电话在昏暗敲响该死的 [03 ：04.07]在世界和cluser面孔之下 [03 ：08.93]，但约翰猛击了他学会的天 [03 ：14.49]那Jonnie他长期不会居住 [03 ：20.06]声音对他的父亲现在认为 [03 ：24.74] Jonnie这里有一个婴孩 [03 ：30.11]没人似乎想要他 [03 ：33.90] [03 ：35.94]婴孩没有他的父母 [03 ：40.49] 2个月老和以一个对无眼 [03 ：46.65] Josie劫掠了电话从约翰 [03 ：51.79]二他们是认为 [03 ：57.51]如此约翰和Josie 60 [04 ：采取在一个全新的婴孩的02.52] [04 ：07.78]命名的保罗Antonio [04 ：13.29] Jonnie将爱他 [04 ：18.24] [04 ：18.99]没什么强比爱 [04 ：23.90]约翰和Josie头为Jonnie [04 ：29.32]同一爱在他们有散开 [04 ：34.59]再开始由胜利决定的他们 [04 ：39.71]和在恐惧同样可能发生 [04 ：45.27]丢失的保罗在他的时间之前来 [04 ：50.53]约翰和Josie看起来正确的过去它 [04 ：55.51]他们在爱的强大礼物basketing [05 ：01.34]约翰和Josie没有时间 [05 ：07.98]他们是篮子在爱的强大礼物

The Underwriter may terminate its commitment under the Underwriting Agreement at any time prior to the Latest Time for Termination if: there shall develop, occur, exist or come into effect: any new law or regulation or any change in existing laws or regulations or any change in the interpretation or application thereof by any court or other competent authority in Hong Kong or any other place in which any member of the Group conducts or carries on business; or any event or series of events resulting or likely to result in any change in local, national or international financial, political, military, industrial, economic or market conditions; or any change in the conditions of local, national or international securities markets (including but without limitation, the imposition of any moratorium, suspension or restriction on trading in securities generally on the Stock Exchange due to exceptional financial circumstances or otherwise); or any change or development involving a prospective change in Hong Kong taxation or exchange control which will or may affect the Group or a proportion of the existing Shareholders of the Company in their capacity as such, which, in the reasonable opinion of the Underwriter:(1) is or will or is likely to have a material adverse effect on the business or financial condition of the Group as a whole or the Rights Issue; or (2) has or will have or is likely to have a material adverse effect on the success of the Rights Issue or the level of Rights Shares taken up; or (3) makes it inadvisable or inexpedient for the Company to proceed with the Rights Issue; or there comes to the notice of the Underwriter: any matter or event showing any of the representations, warranties and undertakings made by PIL and the Company was, when given, untrue or misleading or as having been breached in any respect; or any breach by any of the other parties to the Underwriting Agreement of any of their respective obligations or undertakings under the Underwriting Agreement or under any of the PIL Letter of Undertaking, Option Undertakings or the Sub-underwriting Letter, then and in any such case the Underwriter may, upon giving notice to the Company and PIL, terminate the Underwriting Agreement with immediate effect.

倘发生下列事件，包销商可于最后终止时间前任何时间终止其根据包销协议之责任：以下情况将会出现、发生、存在或生效：香港或本集团任何成员公司经营或从事业务所在任何其他地方之法院或其他主管机关颁布任何新法律或法规，或更改现行法律或法规，或有关法律或法规之诠释或应用有变；或发生任何事件或连串事件导致或可能导致本地、国家或国际金融、政治、军事、工业、经济或市况有变；或本地、国家或国际证券市场之状况有变（包括但不限于因特殊金融状况或其他原因而暂时禁止、暂停或限制港交所之整体证券交易）；或香港税务或外汇管制有变或出现可能导致变动之事态发展，而将会或可能对本集团或本公司部份现有股东产生影响，而包销商合理认为上述情况：(1)会或将会或可能会对本集团整体之业务或财务状况或供股有重大不利影响；或(2)经已或将会或可能会对供股之成功或供股股份之认购数量有重大不利影响；或(3)令本公司进行供股变得不智或不宜时；或包销商得悉：任何事情或事件显示太平船务及本公司所作出之任何陈述、保证及承诺于作出时在任何方面属失实或构成误导或遭违反；或包销协议之任何其他订约方违反彼等各自根据包销协议或任何太平船务承诺函、购股权承诺或分包销函件之任何责任或承诺，而在此情况下，包销商可向本公司及太平船务发出通知即时终止包销协议。

If what the girl grows is beautiful, you are direct boast she is beautiful, although her front is pie-eyed, you are OK still boast her flank, end face, underside, or a certain angle, it is rear and beautiful even, if 361 degrees pie-eyed, you say him a certain expression, a certain instant is beautiful, in any time like fructification any angle did not have a law to bear that you also do not abandon, more not strong praise she is beautiful, seem to be in mock other people in that way, you can say her figure is good, or at least one part figure is very good, the bosom is good say the bosom is good, the bosom is no good say a small of the back, the waist is no good say buttock, buttock is no good say a leg, the leg is no good say arm, arm is no good say a hand,"Your hand look is very good ah ", leng Buding cast going out also have power one sentence very much so, if these parts accident is differ in what outside going out, enter is honest do not have the mouth below the law, that or can undertake eulogizing with respect to adjunct of a few surface layer, e.g.,"It is really good that your hair pledges, inherent, follow your father?"

假如女孩长的漂亮，你就直接夸她漂亮，即使她正面不漂亮，你还可以夸她侧面，顶面，底面，或者某个角度，甚至是背面漂亮，假如三百六十一度都不漂亮，你就说他某个表情，某个瞬间漂亮，假如实在任何时间任何角度都没法忍了那你也不要放弃，更不要硬夸她漂亮，那样似乎在讽刺人家，你可以说她身材好啊，或者最少一部分身材很好，胸好就说胸好，胸不行说腰，腰不行说臀，臀不行说腿，腿不行说胳膊，胳膊不行说手，&你手形很不错啊&，冷不丁的抛出往这么一句也是很有杀伤力的，假如这些部分都是非不一里出外进的实在没法下嘴，那还是可以就一些表层附属物进行歌颂，比如说，&你发质真好，天生的吧，随你爸爸吧？&

In the gold I do not know when to disappear, but regret is gold, I do not know is the gold or the ignorance of fools gold, or gold, the stupid, because the life of a people to get through, obviously have a look at light, but suddenly disappeared , this has been considered to be friends, the twinkling of an eye has become a fantasy, too naive individual gold each picked him as a diamond stone, but I do not know it was not a stone that suddenly disappeared, the stones told of his dream of gold , gold stone, he also told of the plans, may God缓过gold has not disappeared in the sea to stone, and gold found along the way that people had not thought of lost gold and lost a stone but it is also touch gold He was no light, he also lost the value of gold as a financial one for the mud Pakistan, gold has lost a stone has become a mud Pakistan, and Pakistan that the mud has to be done Have you ever thought of mud Pakistan, and Pakistan has no mud to become the sun above the earth, he knew that one day, sooner or later will become the sun, gold may be done, and may not do, you may also be less than a lifetime, then how do find a rock, or you have to rely on their parents ?

在金子不知到的时候消失，却是让金子感到后悔，不知是金子的无知还是金子的傻，还是金子的笨，一辈子就因该一个人度过，看着明明中有了光芒，却突然消失，本认为是有了朋友，转眼却成为了幻想，金子个人太天真了，每次捡到石头就把他当做钻石，却不知那是不是突然之间那石头消失了，石头告诉金子他的梦想，金子也告诉了石头他的计划，可在金子还没有缓过神来石头消失在海里了，金子以为找到了一路人，却不曾想过要失去，一但金子失去的石头，那摸金子也就没有他原来的光芒，也就失去了他的价值，金子一为财务一为烂泥巴，金子失去了石头就成为了烂泥巴了，那这个烂泥巴有没有想过一直要做烂泥巴了，没有烂泥巴一直想要成为地球上面的太阳，他知道迟早有一天会成为太阳，金子可能作到了，可能没作到，可能一辈子也作不到，那摸石头怎么办了，还是一直依靠父母吗？

I have a lot to learn from him, I want to have iron will and indomitable spirit like him; I am a bit weak-willed and give up easily, I do not have a strong perseverance, so I want to have an unswerving spirit just like him.

他身上实在有我许多要学习的，我要像他一样有钢铁般的意志和毅力，我的意志有点薄弱，动不动就放弃，毅力也不算强，所以一定要跟他一样有钢铁般的意志和毅力。

You are gonna have a lot of unskilled laborers, you are gonna have a lot of bricklayers, you are gonna have a lot of people that have some sort of skill, but they are not gonna be required to know more than a whole lot.

你逍遥有许多没有技术的劳动者，你将要许多的砖匠，你将要许多有某种技能的工人，除此之外你没有被要求知道更多了。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐