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With an orthogonal experiment design , the telomerase inhibitors [azidothymidine , AZT 300 mg/ and lamivudine 150 mg/, per os , bid ,×2 weeks ] and X2irradiation [ total dose 10 Gy (2 Gy ×5) in 1 week ] were used to treat BALB/ c mice carrying breast cancer MA782 for evaluating the influence on peripheral blood cells , bone marrow nucleated cells and telomerase activity.

为了探讨端粒酶抑制剂联合X 线照射对荷瘤小鼠的骨髓抑制作用,采用正交实验设计,应用端粒酶抑制剂[AZT 300 mg/, lamivudine 150 mg/ ]联合X 线照射(2 Gy ×5次/ 1 周)处理移植性乳腺癌(MA782 )小鼠,观察其对骨髓有核细胞、外周血像及骨髓端粒酶活性的影响。

In the combined treatment of the craniopharyngiomas, it is very important to prevent the irradiation injury of the surrounding structures such as the optic nerve, chiasm, hypothalamus and vascular structures. In those structures, the optic nerve and chiasm are the most sensitive ones to the irradiation, and their ability to bear the irradiation is about 9 to 12 Gy. So if the irradiation dose is lower than 9Gy, the treatment will be safe. We have not found any report about the bearability and side effect of the hypothalamus related to the gamma knife radiosurgery.

在治疗过程中,预防病变周围的重要结构如视神经,视交叉,丘脑下部和血管结构的放射性副损伤是非常重要的,在这些重要结构中,视神经和视交叉对放射线最为敏感,其耐受能力约为9~ 12 Gy,因此如果对这些结构的放射剂量在9Gy以下,治疗将是安全的,目前尚无有关丘脑下部的耐受剂量和放射性损伤的文献报道。

Most tumors were response to the initial radiotherapy at the range of 55 to 65 Gy.

大部份的肿瘤在接受55-65 Gy的剂量后均有良好的反应。

Results : The median age was 58 year-old. The median radiotherapy dose of 24 patients was 54.5 Gy.

结果:全体 24 位病患其年龄中位数是 58 岁,接受放射线剂量中位数为 54.5 Gy (36~66 Gy)。

Patients usually received external beam irradiation 39.6 Gy to 61.2 Gy to the whole pelvis, and the vaginal cuff were boosted by intravaginal brachytherapy.

体外放射线剂量通常全骨盆腔接受39.6至61.2 Gy之肿瘤剂量,另外在阴道缝合缘再追加腔内近接治疗。

The MBP content of telencephalon tissue in control rats were 78~82 礸/ml, there were no difference in all the 2 Gy irradiated, 1 week and 1 month after 10 to 30 Gy irradiated groups.

髓鞘染色显示30 Gy照射后6月大鼠在胼胝体区有较典型的脱髓鞘病变存在。10~30 Gy照射后1~6个月各组在超微结构上也有不同程度的髓鞘异常。

However, the size and number of colonies are less than which in anaerobic TYL medium. It can not grow in aerobic TYL and TYG media. Bifidobacterium longum can tolerate radiation dose as high as 80 Gy, which is the total dose in clinical radiotherapy. Therefore, Bifidobacterium longum has the potential to be the vector for cancer gene therapy combining radiotherapy. Besides, this is the first study to investigate the tolerance of X-ray radiation for Bifidobacterium longum.

此外,从本研究中得知Bifidobacterium longum可耐受高达80 Gy的辐射剂量(单次照射,存活分率为22 %;以分次照射每次给予2 Gy来估算,存活分率为67%),此剂量为临床放射治疗一般给予的总剂量,因此证实Bifidobacterium longum有很大的潜力做为癌症基因治疗合并放射治疗的载具,本研究也是首篇调查Bifidobacterium longum对放射线耐受性的研究。

The test of white blood cell count was finished by the different number of bifidobacterium suspension coloclysis and general irradiation with 5.0 Gy γ ray to establish acute radiation damage pattern.The 30 survival rate was tested and reported after the bifidobacterium suspension coloclysis of 1×109CFU/ml and 5.0 Gy ray to establish acute radiation damage pattern number in every day.

WBC计数:用不同数量级浓度的双歧杆菌菌悬液对小鼠灌肠28 d后,5.0 Gy照射后3 d、6 d和10 d采取小鼠外周血检测WBC数。30 d小鼠生存率:用1×109CFU/m l双歧杆菌菌悬液灌肠28 d后,用一次性8.0 Gy60Coγ射线全身照射,建立急性放射损伤模型,每日上下午各观察小鼠1次,记录死亡动物数和死亡日期。

Marginal dose of 10-12 gy to isodose line of 40-60% was delivered to the lateral temporal cortex, and 16-20 gy to 50% to the homolateral amygdale and hippocampus.

颞叶外侧皮质靶区边缘剂量10~12 gy,等剂量曲线40%~60%;加行同侧海马、杏仁照射,边缘剂量16~24 gy,等剂量曲线50%。

Methods Fifty-five pure-blooded New Zealand rabbits were randomly divided into the control group, and 20 Gy and 30 Gy irradiated groups (left lung exposed to 6 MV X-ray generated by linear accelerator, 2 Gy/min).

方法将纯种新西兰白兔55只分为对照组、20和30 Gy照射组(照射组再各分5个亚组),5只/组。

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