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Materials and Methods: There were 91 prostate cancer patients included in this study. We analyzed the characteristics of each item of the EORTC QLQ-C30 and EORTC QLQ-PR25 by CTT and IRT. The infit statistics of Rasch model was used to examine the unidimensionality of each domain, and also evaluate the item difficulty, the range of item threshold, item targeting and the reliability of the two questionnaires. Furthermore, patients were measured before therapy and at 1, 3 and 6 months after the start of therapy and then compared each health-related quality of life score of the post-therapy groups with the baseline scores. Finally, the item psychometric properties were examined for different groups stratified by age and disease severity.

材料与方法：本研究共计收案91名摄护腺癌患者，利用传统测量与项目反应理论（item response theory， IRT）比较分析问卷各题目的特质，以适合度指标检验各向度是否符合单一向度的假设，并检验每一题目的难度、门槛值范围、适中性，以及问卷的信度；然后，再检验各题目在治疗前后、不同疾病严重度或不同年龄族群中之心理计量特质是否相同。

The results showed:(1) MP polymerase chain reaction test showed positive results in the bronchoalveolar lavage fluid from all of the MP-infected rats (infectious group, n=4), while they were all negative in BALF from the control group (n=4,P＜0.05) and from those rats both infected with MP and, at the same time, treated with erythromycin (treating group n=4,P＜0.05). Bacterial cultures of the bronchial and lung tissue were negative in all three groups. Using transmission electron microscope the widened interalveolar septa with increased amount of collagen were found in the infectious group, while there were no obvious abnormalities in the other two groups.

结果显示：(1)感染组动物(n=4)支气管肺泡灌洗液肺炎支原体-PCR检测均为阳性，而对照组(n=4)和感染加红霉素治疗组动物(n=4)均为阴性(P＜0.05)；三组动物的支气管和肺组织常规细菌培养结果均为阴性；感染组动物透射电镜检查见肺泡间隔增宽，其中有较多胶原纤维堆积，其余两组则未见明显异常。

Methods Forty-eight patients with malignant pleural effusion were randomly divided into two groups, 25 patients were treated with IL-2 and carboplatin by intrapleural injection in treatment group, and 23 patients were treated with carboplatin by intrapleural injection only in control group. The changes in volume of pleural effusion and side effects were observed in two groups.

将48例恶性胸水患者随机分为治疗组和对照组，治疗组25例应用IL-2加卡铂胸腔灌注，对照组23例单纯应用卡铂治疗，观察治疗前后胸水变化和副作用。

Except for control group, rats in the other groups were intratracheally administered with bleomycin. Animals in pulmonary fibrosis model groups were sacrificed on day 3, 7, 14, 28 and 56. The sections of the right lung were stained by HE, Masson and sirius red.

除N组外，其余各组采用气管内注入BLM致大鼠肺纤维化模型，分别于3、7、14、28、56 d处死各组大鼠，右肺行苏木精-依红、Masson胶原及天狼猩红染色，测定左肺羟脯氨酸的含量。

Except for control group, rats in the other groups were intratracheally administered with bleomycin. Animals in pulmonary fibrosis model groups were sacrificed on day 3, 7, 14, 28 and 56. The sections of the right lung were stained by HE, Masson and sirius red. The left lung was weighed and its hydroxyproline content was assayed. The mRNAs of TGF-β1, MMP-9 and TIMP-1 in the lung homogenate were measured by semi-quantitative RT-PCR.

除N组外，其余各组采用气管内注入BLM致大鼠肺纤维化模型，分别于3、7、14、28、56d处死各组大鼠，右肺行苏木精－依红、Masson胶原及天狼猩红染色，测定左肺经脯氨酸的含量RT-PCR法半定量测定转化生长因子－1(TGF-β1)、基质金属蛋白酶－9(MMP-9)和基质金属蛋白酶组织抑制物－1(nMP-1)mRNA在肺内的表达。

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准确的说，今天的主题应该二个：1、借助节日的生气，让你的流量火起来2、个人应该做什么样的网站谈不上什么讲课，应该是和大伙交流一下我的经验好了废话不多说了，下面开始经常在坛子里或者群里看到有些人为了增加几个IP，烦的要死甚至有些新站长为了增加IP，竟然花钱买流量而买来的流量还都是假流量，结果花了钱，还没有得到有用的IP访问既然那么多人想要更多的IP访问，今天我就叫大伙怎么样获得更多的流量中国有很多节日，比如：国庆\圣诞\元旦\春节等等而每个节日的气氛都很浓

Methods: According to the mechanism of cough reflex, the c-fibres's role in the respiratory system, and the principle of isosterism. Here, a peripheral antitussive LD was regarded as a lead compound. Amino functional groups, as substituents at the 1-hydroxy group of the racemate of LD, were introduced into the structure of the molecule. These novel compounds were confirmed by 1H-NMR, MS spectrum. Their antitussive activities were studied on mice in sequential method. The EDT50, the stimulating time that caused cough by NH3 on half of mice, were measured. Then could caculated the ratio R between the EDT50 of the treated groups and control group.

根据咳嗽反射的机制及C-纤维在呼吸系统的作用，以外周镇咳药左羟丙哌嗪为先导化合物，依据电子等排原理，在其结构中引入氨基以取代羟丙哌嗪分子中1位的羟基，设计一系列未见报道的化合物（01-15）；并采用了一条适宜的路线进行合成，通过1H-NMR、MS确证结构；采用&序贯法&实验进行新化合物的镇咳活性研究，动物模型采用氨水引咳小鼠，获得引致半数小鼠咳嗽的氨水刺激时间（EDT50）及给药组EDT50与对照组的比值R。

It is speculated that this components feedback adjusting the this receptor\'s expression through receptor-binding with 5-HT3A receptor.3.3 Effection of Iridoids composition of Valeriana jatamansi Jones on THP1 mRNA expression of IBS rats induced by chronic stressMethods:Animals were randomly divided into 6 groups:normal group,model group, OSD group,FXT group,MSP group and Iridoids composition of Valeriana jatamansi Jones groups.

表明蜘蛛香环烯醚萜不影响色氨酸羟化酶的转录表达。3.1.3蜘蛛香环烯醚萜对5-HT受体的影响目的：探讨蜘蛛香环烯醚萜对慢性应激所致IBS大鼠5-HT3受体mRNA表达的影响方法：动物随机分为对照组、模型组、昂丹司琼组、氟西汀组、蜘蛛香环烯醚萜24.92mg/kg、12.46mg/kg、6.23mg/kg组，除对照组外，其余各组进行慢性应激实验。

Sugar water choosed degree have no significant change. It means that Iridoids composition of Valeriana jatamansi Jones has central inhibitory action.2.2 Effection of Iridoids composition of Valeriana jatamansi Jones on weight and food intake of IBS rats induced by chronic stressAnimals were randomly divided into 7 groups:normal group,model group, OSD group,FXT group and Iridoids composition of Valeriana jatamansi Jones groups in quantiy of 24.92mg/kg,12.46mg/kg,6.23mg/kg.

蜘蛛香环烯醚萜可以减缓正常小鼠的胃肠运动和利血平化小鼠的胃肠功能亢进，降低慢性应激所致IBS模型大鼠的内脏敏感性，显著减少了IBS模型大鼠的排便数量，从而改善腹泻型IBS的临床症状。2蜘蛛香环烯醚萜对神经系统功能的影响目的：探讨蜘蛛香环烯醚萜对精神活动的影响2.1蜘蛛香环烯醚萜对慢性应激所致IBS大鼠精神活动的影响方法：动物随机分为对照组、模型组、昂丹司琼组、氟西汀组、蜘蛛香环烯醚萜24.92mg/kg、12.46mg/kg、6.23mg/kg组，除对照组外，其余各组进行慢性应激实验。

It is speculated that this components feedback adjusting the this receptor\'s expression through receptor-binding with 5-HT3A receptor.3.3 Effection of Iridoids composition of Valeriana jatamansi Jones on THP1 mRNA expression of IBS rats induced by chronic stressMethods:Animals were randomly divided into 6 groups:normal group,model group, OSD group,FXT group,MSP group and Iridoids composition of Valeriana jatamansi Jones groups.

表明蜘蛛香环烯醚萜不影响色氨酸羟化酶的转录表达。3.1.3蜘蛛香环烯醚萜对5-HT受体的影响目的：探讨蜘蛛香环烯醚萜对(来源：ABC论文aaaaaa网www.abclunwen.com)慢性应激所致IBS大鼠5-HT3受体mRNA表达的影响方法：动物随机分为对照组、模型组、昂丹司琼组、氟西汀组、蜘蛛香环烯醚萜24.92mg/kg、12.46mg/kg、6.23mg/kg组，除对照组外，其余各组进行慢性应激实验。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。