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Objective to evaluate the functional recovery of acute spinal cord injuried rats treated with exogenous wnt-3a signal protein administration and to explore its mechanism.methods moderate spinal cord contusion injury was made in 40 adult sprague dawley rats at t10.twenty rats served as contusion controls(group 1).twenty rats were treated with wnt-3a for three days after injury (group 2).the functional recovery of the rats was observed through basso,beattie,bresnahan open field locomotor score.rats were killed at 14 or 28 days after injury,then spinal cords were removed for histopathological examinations,and the expression of the bromodeoxyuridine plus neural cell markers was stained with immunohistochemical method.results rats of two groups receiving a contusive injury recovered substantial function within 1 week.by 28 days,rats in groups 2 scored 7.0 points better on the bbb scores than rats in group 1 group 2=16.94,after 28 days vs.

目的 研究外源性wnt-3a信号蛋白对脊髓损伤的修复作用,并探讨其作用机制。方法取40只成年雌性sd大鼠在t10节段制备适度脊髓挫伤模型。随机从中取20只为损伤对照组(group 1),另外20只为损伤治疗组(group 2)。脊髓损伤3天后用wnt-3a蛋白治疗。这些大鼠的功能恢复通过basso、beattie、bresnahan开放视野运动评分来观察。这些大鼠分批在损伤后14天或28天被处死,取出损伤节段脊髓用来组织病理学检查,同时用5-溴脱氧尿嘧啶核苷和神经细胞标记物进行免疫组化染色。结果两组大鼠在伤后一周运动功能有明显的恢复。不过,到损伤后28天,我们观察发现,损伤治疗组中的大鼠bbb评分比损伤对照组中的评分高出7.0分左右(group 2∶16.94±1.18,group 1∶9.89±1.29;p.05),光镜和电镜检查发现wnt-3a蛋白对髓鞘形成和轴突再生有一定的修复效果。

A term that originally referred to the process by which two or more languages converge to form a new language when different cultural groups interact over an extended period, creolization has been gradually extended to describe the transformations undergone in various aspects of culture when two or more groups come into prolonged contact.

最初这个术语指的是当不同的文化群体长时间相互影响后,两种或更多种语言汇合而形成一种新语言的过程。后来这个词的词义逐渐扩展,用来表达两个或更多的群体经过长时间的接触,其文化在诸多方面所产生的变形。

In commonly cribble and ultra-fine powder group, heavy, middle and slight dose groups were included. Every heavy, middle and slight dose groups mice were administered with the pulyis by gavage every day at 0.6mL, 0.4mL, 0.2mL and every NS group mouse were ig 0.4mL NS every day.

低、中、高剂量组小鼠分别灌服1∶1的&促免散&粗粉、微粉煎液0.2mL/只/天、0.4mL/只/天和0.6mL/只/天,生理盐水对照组小鼠灌服生理盐水0.4mL/只/天,共灌药6天。

To study the effect of avilamycin and narasin on the intestinal microflora of Cyprinus carpio, the concentrations of avilamycin of both groups were 4mg/kg and 8mg/kg feed respectively, and the concentrations of narasin of both groups were 20mg/kg and 40mg/kg feed respectively.

在研究阿维拉霉素和甲基盐霉素对鲤肠道菌群影响的试验中,各组饲料中添加阿维拉霉素的浓度分别为4mg/kg、8mg/kg基础饲料;添加甲基盐霉素的浓度分别为20mg/kg、40mg/kg基础饲料。

Six weeks after drug intervention,we found,in ADM+Res group,the mean tumor volume of MCF-7/ADM cells implanted tumor was 1.203±0.338 cm~3 with statistical significance to compare with other groups(P<0.05),decreased about 50.58%compared with the mean tumor volume of ADM alone group1.979±0.307 cm~3the result of the mean tumor weigh was alike to the mean tumor volume; compared with the control,Res could relieve weigh loss(P<0.05,and the toxicity of treatment was not obvious;Microscopic examination showed that there was massive area of cytoclasis and apoptosis in the tumor tissue of the combination group comparing with other groups.

实验结果提示用药6W后,ADM+Res组移植瘤体积(1.203±0.338)cm~3明显小于其余各组,抑瘤率为50.58%,与单用ADM组(1.979±0.307)cm~3相比有差异P<0.05肿瘤重量的结果与瘤体结果类似;未观察到用药后的毒副作用;经不同处理后,单独注射Res组小鼠体重较生理盐水组及ADM组有所增加(P<0.05,而ADM+Res组治疗前后体重无差异P>0.05HE结果显示与其他组相比,ADM+Res组肿瘤组织中出现大片坏死区域。

Methods 122patients undergoing percutaneous coronary intervention were ran-domly divided into two groups,61patients in artificial compression bandaging group and the other61patients in direct bandaging group.The incidence of bleeding complications and decannulation compression time were observed in both groups.

进行冠脉介入检查治疗的122例患者,随机分为人工压迫包扎组(61例)和直接包扎组(61例),观察住院期间出血性并发症发生率和拔管压迫时间。

Both groups have the same treatment course of 6 months. By cardiac ultrasonic contrast, both groups were examined before discharge and 6 months after the discharge the LVEDd, LVEF, the peak value of tachogram at prediastole, the peak value of tachogram at diastasis period and calculated the value of E/A.

应用心脏超声检查2组患者AMI后(14±2)d及1个疗程后左室舒张末径、左室射血分数、二尖瓣舒张早期血流速度峰值、二尖瓣舒张晚期血流速度峰值,并计算E/A。

As compared to isop, the coexistence of electron-donating -OH,-C(CH_3_3 or electron-withdrawing groups (-NO_2) groups in the dicarboxylate derivatives has a significant effect on the molecular self-assembly.

同间苯二甲酸相比较,含有取代基的5-羟基间苯二甲酸、5-硝基间苯二甲酸和5-叔丁基间苯二甲酸在一定程度上影响着配位聚合物的自组装。

During the process of the experiments, in order to make the modified resin got a good balance of reactivity and hydrophilicity, the relatively content of epoxy groups and hydrophilic groups in the modified resin was adjusted by changing the dosage of diethanolamine.

在实验中,通过改变二乙醇胺用量,控制改性环氧树脂分子中环氧基和极性基团的相对含量,使改性树脂的反应性和亲水性达到合理的平衡,解决了以往化学改性法不能二者兼得的问题。

When the resulting nitro compounds was reduced over 5% Pd/C catalyst, the nitro phosphinic acids required more catalyst that the esters nitro phosphinic acid, and dinitro compounds required more catalyst than mono-nitro compounds in the case of all nitro groups completely changed into amino groups.

用5%Pd/C作催化剂,将上述硝基物还原时发现,次膦酸形成的硝基物比次膦酸酯形成的硝基物需要更多催化剂才能使硝基全部还原成氨基;二硝基化合物比单硝基化合物需要更多的催化剂。

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