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Methods: The health adult human primary hepatocyte microsome was randomly divided into 12 groups for control and itraconazole with different concentrations in the range of clinical drug blood concentration, each group have 10 samples. Control groups were added culture fluid, itraconazole groups were added itraconazole with different concentration respectively, after cultured 30 minutes, substrates (phenacetin for CYP1A2, testosterone for CYP3A4) were added and cultured for another 40 minutes.

采用健康成人肝细胞微粒体,分为对照组和不同浓度的伊曲康唑组,共12组,每组10个样本,伊曲康唑组分别加入血药浓度范围内不同对应浓度的伊曲康唑,对照组仅加入培养液,孵育30 min后,再加入CYP450同工酶1A2和3A4的相应底物再孵育40 min。

And then with the help of the IP -groups' constructions, studies will be centered on its nature, and its relations with the finite solvable subsimple group and the finite groups in which every element has prime order and applying the two principles on IP -groups.

随后利用IP -群的结构,重点来研究其性质,指出它与可解有限次单群、质元群之间的包含关系,并且将质元群中的两个重要性质推广到IP -群中。

The the pupation peak of the univoltine groups and the bivoltine groups were obvious,but the trivoltine groups were not obvious.

一、二化性的种群化蛹盛期较明显,而三化性的种群则无明显的化蛹盛期。

The difference between the test groups and the control group was statistically significant. It could be deduced that all the insecticides tested in this experiment damaged the spiders′ intestinal mucosa, compromising its function as a barrier and letting large molecules such as FTIC-D more easily penetrate. Among the insecticides, pyrethrin and Bt preparation are bio-insecticides, and the FITC-D concentrations of the spiders exposed to these two bio-insecticides were more than those of the spiders exposed to the chemical insecticides imidacloprid and dipterex. The difference between the bio-insecticide groups and the imidacloprid group was significant, but there was no significant difference between the bio-insecticide groups and the dipterex group.

结果表明:4种杀虫剂处理后拟环纹豹蛛血液中的荧光素浓度远高于对照组,各个处理组拟环纹豹蛛血液样本中的荧光素浓度均与对照组存在极显著差异,可见4种杀虫剂均将对拟环纹豹蛛肠黏膜的屏障功能造成损伤,导致大分子物质易于通过;其中1.5%除虫菊素水乳剂三保奇花和Bt制剂强杀处理后拟环纹豹蛛中肠黏膜的通透性高于仿烟碱类化学杀虫剂吡虫啉处理组,差异达到显著水平,但与有机磷杀虫剂敌百虫处理组差异不显著。

The results show that: the functional groups in coal are the function of coal rank , and the yields of CO 2, H 2O and CO are related to the content of carboxyl, hydroxyl and other oxygen containing groups such as ether groups in coal, and Tar and CH 4 are related to the aliphatic CH, the char yields to the aromatic CH.

借助化学分析和FTIR光谱分析对我国煤化程度不同的18 种煤中官能团的研究表明:煤中官能团含量与煤化程度有关;煤中羧基、羟基及醚键等其他含氧官能团的含量与热解生成物CO2、H2O 和CO 的产率有关,脂肪—CH 的含量与甲烷和焦油的产率相关联,芳香—CH 的含量与热解半焦产率有关。

Value is the product of the relationship of demand and supply between subjects and objects Subjects consist of three levels such as human totality,groups subjecting to the human totality,and human individuals Coresponding to it,objects include the outside world with respect to human totality(groups+individuals+the world outside human being),the outside world with respect to human groups,and the outside world with respect to human individuals Therefore,things possess value,so do human beings Because humans themselves are the unity of subjects and objects,humans have selfvalue The reciprocal function of the factors constituting value decides the production of value,promote the changes of value,which is the basic subject of thelaw of value The three factors which have influence on the changes in value are the demand of subjects.the character of objects.and practice The origin of the conflicts of value concepts lies in the differences and opposites of the living conditions of human subjects The direct originis the differences and opposites of value objects Therefore,in order to gradually eliminate the conflicts of human value concepts,the differences of the living conditions of human subjects must be eliminated thoroughly

价值是主客体之间需要与满足关系的产物。主体有人类整体、人类整体之下的群体以及人类个体三个层次,与之相应,客体也包括与人类整体相对的外部世界(群体+个体+人以外的世界)、与人类群体相对的外部世界以及与人类个体相对的外部世界。因而不仅物具有价值,人亦有价值。由于人自身是主客体的统一,因而人还有自我价值。构成价值的各个要素相互作用决定价值的生成、推动价值的变化,这是价值规律的基本内容。影响价值变化的主要有主体需要、客体属性及实践三个要素。价值观念冲突的最终根源在于人类主体生存条件之差别和对立,直接根源则在于价值客体的差别和对立。因而要逐步消除人类价值观念的冲突就必须从根本上消除人类主体生存条件方面的差别做起。

In some embodiments where adhesion and alkali removability need to be independently controlled it is preferable that the carrier vehicle comprises two or more types of metal chelating groups wherein at least one of the metal chelating groups is an acid group and at least one of the metal chelating groups is not an acid group.

在有些体现在附着力和碱取出需要独立控制,这是可取的,承运人车辆由两个或两个以上的金属类型螯合组其中至少有金属螯合集团之一,是一种酸组和至少一个金属螯合组不是一个酸组。

To produce the scientific evidence for developing and manufacturing new antitumor drugs.Methods: 1 The inhibitory effect on cell growth of Hela was measured by MTT assay in treated or untreated groups (3.125, 6.25, 12.5, 25, 50μg/ml TAM and control) for three different treatment times (24h, 48h and 72h).2 Apoptosis and cell cycle were measured by FCM in four experimental groups (0, 4, 16, 40μg/ml TAM) for 48h.3 Adopting Wright and Giemse's staining to observe the morphology of Hela cells which treated with 40μg/ml TAM.4 Using invasion experiment to detect the Hela cells'invasive abilities which treated with 40μg/ml TAM.5 The protein expressional levels of P-ERK, ERK, C-myc and Cyclin D1 in Hela cells untreated or treated with 4, 16, 40μg/ml TAM for 24h were measured by Western blot.6 Expression of anti-apoptotic gene bcl-2, apoptotic gene bax and MMP-9 in Hela cells of four experimental groups (0, 4, 16, 40μg/ml TAM for 24h), were observed by revers transcription PCR.7 The protein expression of P-ERK, ERK, Bcl-2 and Bax in Hela cells treated with 40μg/ml TAM for 24h observed by laser scanning microscopes.

1采用四甲基偶氮唑蓝法检测不同浓度北豆根总碱(3.125、6.25、12.5、25、50μg/ml)处理不同时间(24、48和72小时)对Hela细胞增殖反应的抑制作用。2采用流式细胞技术(flow cytometry,FCM)检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用48小时,对Hela细胞凋亡及周期变化的影响。3瑞氏-姬姆萨染色后显微镜观察北豆根总碱(0、40μg/ml)作用24小时后Hela细胞形态学变化。4采用Transwell小室法检测北豆根总碱(0、40μg/ml)作用24小时后对Hela细胞侵袭性的影响。5采用免疫印迹方法检测不同浓度北豆根总碱(0、4、16、40μg/ml)作用24小时后,Hela细胞中磷酸化ERK、ERK、C-myc、CyclinD1的表达变化。6采用逆转录-聚合酶链反应(revers transcription PCR,RT-PCR)半定量检测北豆根总碱(0、4、16、40μg/ml)作用24小时,Hela细胞抗凋亡基因bcl-2、促凋亡基因bax、基质金属蛋白酶-9(MMP-9)的表达变化。7应用激光共聚焦显微镜(laser scanning microscope,LSM)观察北豆根总碱(0、40μg/ml)作用24小时后,Hela细胞内P-ERK、ERK、Bcl-2、Bax蛋白的表达变化。

Accuracy between two groups was calculated byχ~2 test.Calculate the average effective radiation dose of the 30 patients.Results In group A,seventeen patients underwent both DSCT coronary angiography and SCAG,among 255 segments of 17 patients,105 lesion sites of 70 segments were diagnosed stenosis or obstruction,of them,95 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 90.48%.The agreement of two methods have a high agreement(Kappa =0.853).In group B,13 patients underwent both DSCT coronary angiography and SCAG,among 195 segments of 13 patients,73 lesion sites of 57 segments were diagnosed stenosis or obstruction, of them,65 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 89.04%.The agreement of two methods have a high agreement(Kappa =0.835). There was no significant difference(χ~2=0.098,p>0.05) between the accuracy of two groups.The effective radiation dose of 30 patients was 3.67±0.43 mSv.Conclusion Compared with SCAG,prospectively ECG-gated transverse DSCT is a valuable examination to detect and diagnose coronary artery disease with a low dose coronary angiography.The accuracy of the DSCT is approximate to the SCAG.There was no significant difference between the accuracy of two groups.

结果200例患者均成功完成了适应性前瞻性心电门控双源CT冠状动脉血管成像;30例同期行SCAG检查的患者,A组17例:HR≤75 bpm,可评价冠状动脉节段255个,70个冠状动脉节段有105处不同程度的狭窄,95处狭窄程度与金标准SCAG相符,其阳性诊断准确率为90.48%;2种方法的诊断结果得到了较高的一致性(Kappa值=0.853)。B组13例;HR≥91 bpm,可评价冠状动脉节段195个,57个冠状动脉节段有73处不同程度的狭窄,65处狭窄程度与SCAG相符,其阳性诊断准确率为89.04%;2种方法的诊断结果得到了较高的一致性(Kappa值=0.835)。2个心率组间的诊断准确率无明显统计学差异(x~2=0.098,p>0.05)。30例患者的平均有效辐射剂量为3.67±0.43 mSv结论适应性前瞻性心电门控双源CT冠状动脉成像是一种有效减低辐射剂量的扫描方式,其诊断准确率与金标准SCAG相比得到较高的一致性,且高、低2个心率组间诊断准确率无明显统计学差异。

In order to inquire the causes of occurrence of lipoid pneumonia in rat that were raised in standard SPF animal reproductive area, we used self-reproducing standard SPF rats, male 50 and female 50. All of the rats were divided into 10 groups, raised in standard Barrier system, and fed the standard diets imported from U.S.A.. All animals were divided into 4 stages to sacrifice. Autopsy, histopathological and blood biochemical examination were made at each stage. The results reveal that no lipoid pneumonia were found to occur in the 5, 10 and 26-week-old groups of male and female rats. 40% of male and 60% of female were found to occur slight focal lipoid pneumonia in the 52-week-old groups of rats.

利用成大医学院实验动物中心生产的标准无特定病原大白鼠雌、雄各50只分成10组,在屏障系统中进行实验,使用美国进口的标准实验动物饲料餵食,在一年中分四期剖检,并做病理组织学及血液生化学观察,分析比较结果显示5,10及26周龄的雌、雄大鼠皆未发生类脂质性肺炎。52周龄雌大鼠有60%,雄大鼠有40%观察到患有轻度局部性类脂质性肺炎。

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The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因,如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务,你就做你的事好了。

Who is in possession of this?

这是谁的?