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Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

Objectives To study the expressions of STAT1 and PDGF in lung tissue of pulmonary fibrosis model induced by bleomycin in rats, and discuss the possible mechanism.Methods Thirty Wistar rats were randomly divided into two groups (15 in each group), they were bleomycin group and control group.①The BLM group was intratracheally instilled with belomycin (5mg/kg);② NS group was intratracheally instilled with saline (5mg/kg).

目的 观察肺纤维化鼠肺组织信号转导和转录活化因子1（STAT1）和血小板源性生长因子表达的变化，探讨其在肺纤维化的作用机制方法 30只Wistar大鼠随机分博莱霉素组和对照组，①BLM组：气管内灌注BLM（5mg/kg）诱导肺纤维化；②NS组：气管内灌注NS。

A chromium free conversion coating at least equivalent in corrosion protective quality to conventional chromate conversion coatings can be formed on metals, particularly cold rolled steel, by a dry-in-place aqueous acidic liquid comprising: a component of anions, each of said anions consisting of at least four fluorine atoms and at least one atom of an element selected from the group consisting of titanium, zirconium, hafnium, silicon, and boron, and, optionally, ionizable hydrogen atoms, and optionally, one or more oxygen atoms; a component of cations of elements selected from the group consisting of cobalt, magnesium, manganese, zinc, nickel, tin, zirconium, iron, and copper; the ratio of the total number of cations of this component to the total number of anions of component being at least 1:5; sufficient free acid to give the composition a pH in the range from 0.5 to 5.0; a component selected from the group consisting of phosphorus-containing inorganic oxyanions and phosphonate anions; and a component selected from the group consisting of water-soluble and water-dispersible organic polymers and polymer-forming resins and, preferably, also including a component selected from the group consisting of tungstate, molybdate, silicotungstate, and silicomolybdate anions.

通过对包含以下成分的含水酸性液体进行干燥，可以在金属上形成无铬的转换涂层，该涂层与普通铬酸盐转换涂层相比，至少在抗腐蚀质量上等效：$_一种阴离子成分，所述各个阴离子包括至少4个氟原子，至少选自钛、锆、铪、硅与硼元素中的1个原子。任选地可离解的氢原子，任选地1个或多个氧原子；$_一种选自钴、镁、锰、锌、镍、锡、锆、铁与铜元素的阳离子成分，上述成分的阳离子总数与成分内的阴离子总数之比至少为1∶5；$_足够的游离酸以使该组合物的pH值在0.5～5.0的范围内；$_一种选自含磷的无机含氧阴离子与膦酸盐阴离子的成分；$一种选自水溶性与水可分散性有机聚合物与聚合物形成的树脂的成分，优选还包括一种选自钨酸盐、钼酸盐、钨硅酸盐与钼硅酸盐阴离子的成分。

Twelve hours latter,uterine vessels formation was revealed by tannin-Fe lavement solution.Results The uterine vessel formation of rats in the model group showed that varices,tetanic shape,the density of all levels vessel net increased obviously and its twist,serpentine shape decreased markedly,while that in the large,middle dosage Gongning groups displayed absolute contrarily and fit like a glove with the normal control group.The uterine vessel formation of rats in the small dosage Gongning group and indomethacin group also showed the same transformation as it in the model group.

结果 模型组大鼠子宫各级血管扩张增粗，走行僵直，螺旋状和蜿蜒状走行消失或明显减少，血管形成的各级血管网密度增加，分布不均；消炎痛组、宫宁小剂量组子宫血管仍存在较明显的血管腔扩大、走行僵直和血管网密度增加，宫宁大、中剂量组子宫血管构筑的异常改变消失或明显改善。

The clinical characters of oligodontia concluded from this study are following:(1) There is significant difference that more teeth absent and more existent teeth anomalies in patients of oligodontia/S group than in patients of oligodontia/I group, and the peg-shaped upper lateral incisor is the most frequently affected teeth with shape anomaly.(2) Both of the two groups have no significant differences in number of teeth missing between maxilla and mandible as well as that between left and right side.(3) The distribution of teeth missing is bilateral symmetry in both groups, but the frequency of teeth lost are different: excluding the third molar, in oligodontia/I group, the lower second premolar is the most frequently congenitally missing tooth followed by the upper lateral incisor, while in oligodontia/S group, the most frequently missing teeth are mandibular canine and maxillary lateral incisor. Nevertheless, the first molars are the most stable teeth in both groups.(4) In oligodonita/I group, the mean mesiodistal dimensions of all type of existent teeth are significantly smaller than normal value. It is implied that oligodontia is not an isolated phenomenon, but is related to a complex of other dental changes.

对于口腔多个恒牙先天缺失的临床特点有以下初步结论：(1)综合征型先天缺牙患者较单纯型先天缺牙患者恒牙缺失数目更多，平均分别为23.9个和14.9个，且现存牙齿有更多的形态异常，分别为7／10例（70％）和6／22例（27.3％），其中最常见的是上颌侧切牙畸形；(2)两种类型的多个恒牙先天缺失患者的缺牙数目在上下颌及左右侧之间均无差别；(3)两种类型的多个恒牙先天缺失患者在缺失牙位上均呈对称分布，但在具体牙位上有所差异：不计第三磨牙，单纯型先天缺牙最常缺失的牙位是下颌第二双尖牙、其次为上颌侧切牙；而综合征型先天缺牙最常缺失的牙位是下颌尖牙和上颌侧切牙；无论何种情况，第一磨牙均为牙列中最稳定的牙齿；(4)在单纯型先天缺牙患者中，现存恒牙的牙冠宽度较国人正常值偏小，差异显著，提示牙齿形态与多个牙先天缺失有一定相关性。

Objective To detect the effect of cyclophosphamide administered by means of metronomic chemotherapy combined maximum tolerated dose chemotherapy on the angiogenesis, carcinogenesis and metastasis of Lewis lung cancer on C57BL/6 mouse model. Method The mice were randomly divided into four groups:（1）metronomic chemotherapy group,（2）MTD group,（3）combination group（metronomic chemotherapy combined MTD group）,（4）control group.

目的 探讨环磷酰胺节律化疗联合最耐受量化疗对小鼠Lewis 肺癌肿瘤生长、血管生成和远处转移的影响方法荷瘤小鼠随机分4组：分别（1）CTX节律化疗组；（2）MTD组；（3）联合组（CTX节律化疗联合MTD化疗）；（4）对照组。

Effects on reproductive performance: The normal delivery of group B,C and D were 80%、93.33%、93.33%,respectively,were improved by a certain extent comparing with the control group; The mean birth weight of calves were not significantly different between the trial and control groups.But numerical datas shown that supplementing Zn-Met in dietary had the tendency to increase the birth weight of calves; Supplementing Zn-Met in dietary can make dairy cows express empathema earlier,and significantly(P.05).Among the trial groups,the advanced extent of the group C was comparatively large(5.8d);The oestrous cycles were all in normal range and not significantly different; The levels of serum PRL of group B,C and D were significantly(P.05) 1.46 ng/ml、3.08 ng/ml、3.45 ng/ml higher than the group A.

对繁殖性能的影响：添加蛋氨酸锌组的正常分娩率为80％、93.33％、93.33％，较对照组(73.33％)有一定程度的改善；试验组犊牛初生重与对照组犊牛初生重差异不显著(P＞0.05)，但数据结果显示，日粮添加蛋氨酸锌有使犊牛初生重增加的趋势；日粮添加蛋氨酸锌可使奶牛产后发情提前，且差异显著(P＜0.05)，其中，添加蛋氨酸锌240mg／kg组提前的幅度较大，提前了5.8d；试验组发情周期与对照组差异不显著(P＞0.05)，均在正常范围之内；B、C、D组血清促乳素含量均比对照组高，且差异显著(P＜0.05)，依次增加1.46ng／ml、3.08ng／ml、3.45ng／ml，试验组B与C、D两组间也达到显著差异(P＜0.05)。

The natural enemies group, neutral arthropod group and phytophagy arthropod group of the two sub-systems were respectively analyzed and have found that all types of arthropods of the two sub-systems can be divided into three different types of groups. The first group is which living in two habitats and the species current is few impacted by the changes of habitats; The second group is which can living in two habitats in turn ,but can transfer to another in the time the habitats was deeply disturbed ;The third one can only living in one habitats and can make the another habitats as a temporary habitats.

两个亚系统的天敌类群、中性节肢动物类群、植食性节肢动物类群分别进行分析发现两个亚系统的各类群节肢动物均可划分为三种不同类型，第一种为栖居于两种生境且物种流受生境变化影响较小类群；第二种为可依次栖居于两个不同生境，生境的变化对其物种流产生较大影响；第三种为栖居于某一单一生境，但可将另一系统作为某一虫态的临时栖境。

Methods: 48 cases of postmenopausal osteoporosis which were selected from certaindiagnostic standard were randomly divided into two groups: the treatment group(24 cases) andthe control group(24 cases), as a result,,only 42 cases which have full and complete data. Thetreatment group was 20 cases, those who were treated by embedding thread at pishu(BL20)and shenshu(BL23), every two weeks, lasting twelve weeks, while the control group was 22cases, no any treatment for comparison with the treatment group, lasts twelve weeks.

将48例符合病例选择标准的绝经后骨质疏松患者随机分为治疗组和对照组各24例，结果资料完整者42例，其中治疗组20例，予脾肾俞穴位注射埋线法治疗，每2周1次，连续12周；对照组22例，选择空白对照，连续观察12周。

RESULTS: During 10 - 12 weeks, in cuntrol group: The defect area was repaired by white and soft tissue that had no resistance to press. The repaired tissue was still lower than the surrounding articular surface with clear boundary. By histological observation, it was found that the defect was repaired by the mechanism similar to inflammatory reaction and the defect is ultimately filled by the hyperplasia of hyaline degenerative fibrous tissues. In filling group: the defect was repaired by semi-transparent, smooth, textured tissues with polish that had resistance to press as well as elasticity. The repaired tissue was almost similar to the shape of the surrounding cartilage,difficult to be distinguished. After histological observation, it was found that there was no inflammatory reaction, but active hyperplasia of inner bonetissue and cartilage tissues; a lot of osteoid tissues and trabeculation were found. Newlborn cartilage was fused with surrounding cartilage tissue and connected with surrounding tissues.

结果：10～12周，对照组：缺损区由白色、质软、按压无阻抗的组织修复，修复组织仍低于周围关节面，边界仍清晰可辨，组织学以类似炎症反应的机制修复缺损，最终以透明变性的纤维组织的增生来填补缺损部位；填充组：缺损区由半透明状、质韧光滑有光泽，按压有阻抗并有弹性的组织修复，修复组织与周围软骨外形上已基本相似，不易区分，组织学未见有炎症反应的过程，内骨组织和软骨组织增生活跃，并可见大量类骨组织和骨小梁形成，新生软骨和周围软骨组织融合，并与周围组织连接。

The visit of all these marauders must be anticipated, and measures taken to prevent their depredation .

应该预料到这些抢劫者的侵袭，并制定防范他们抢劫的措施。

It is no effect of him whatever threaten or speak the sense.

无论是恐吓还是讲道理对他都不起作用。