查询词典 go to sleep

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

When the mind apprehends the essence of a thing (quod quid est; tò tí en enai), the external object is perceived without the particular notes which attach to it in nature, and it is not yet marked with the attribute of generality which reflection will bestow on it.

当铭记apprehends的本质的东西（狱吏嚼1-5 ；德州仪器恩enai ），外部对象被认为没有特别注意到它重视它的性质（中存在singularibus ），这是没有标明属性一般性的反映将赋予它

objective to study the correlation among psychosomatic health factors,depression,anxiety and sleep status in college students,to analyze influence factors in sleep status.methods with questionnaire opened in-vestigation,200college students were evaluated using cornell medical index,self-rating depression,self-rating anxiety scaleand pittsburgh sleep quality index.stepwise regression analysis was used.re-sults total score of sds was35.55±7.8,and sas was0.48±0.9.each score of cmi was higher than normal range,the highest was digestion system,next was respiration system,then,fatigue,eyes and ears,anxiety,sensitivity,tension,maladjustment in turn.total average score of psqi was6.32±3.6,ordinary sleep were115cases（57.5%）,good and bad sleep were42（21%）and43（21.5%）cases respectively.influence factors in total score of psqi were sas,cmi,respiration system,anxiety,past healthy,digestion system,fatigue,sensitivity,sds and malad-justment in turn,using stepwise regression analysis,total score of psqi as dependent variable,each factor score of cmi,total score of sds and sas as independent variables.conclusion problems of psychosomatic health,anxiety and depression could both lead to sleep disorder.

目的 研究在校大学生心身健康因素及抑郁焦虑等与睡眠状况的相关性，并对影响睡眠状况的有关因素进行分析。方法采用问卷式的开放性研究，对在校的200名大学生进行康奈尔心身健康问卷、自评抑郁量表、焦虑自评量表和匹兹堡睡眠质量量表的测定，采用逐步回归分析方法。结果 sds总分为35.55±7.8、sas总分为0.48±0.9，cmi评分：消化系统最为严重评分为2.52，其次为呼吸系统、疲劳感、眼和耳、焦虑、敏感、紧张、不适应等，评分均高于正常常模。psqi总均分为6.32±3.6，一般睡眠有115例占57.5%，睡眠质量较好42例占21.0%，睡眠质量较差43例占21.5%。评估对睡眠状况的影响程度，以psqi总分为因变量，选择cmi各因子分和sds、sas总分作为自变量，进行多因素逐步回归分析，进入方程的因素依据标准化偏回归系数，影响psqi总分的因素依次为sas总分、cmi总分、呼吸系统、焦虑、既往健康、消化系统、疲劳感、敏感、sds总分、不适应（f=226.8；p.01；r=0.73）。结论心身健康问题和焦虑抑郁可导致睡眠障碍。

N6 Go go go go Go go go shawty It''s your birthday We gon party like it''s yo birthday We gon sip Bacardi like it''s your birthday And you know we don''t give a ** It''s not your birthday Go go go go Go go go !

小甜心，这是你的生日我们聚在一起就象这是你的生日！我们喝百加德就象这是你的生日！你知道其实我们也不在乎这是不是你的生日！

Go go go go Go go go shawty It''s your birthday We gon party like it''s yo birthday We gon sip Bacardi like it''s your birthday And you know we don''t give a ** It''s not your birthday Go go go go Go go go !

小甜心，这是你的生日我们聚在一起就象这是你的生日！我们喝百加德就象这是你的生日！你知道其实我们也不在乎这是不是你的生日！

Http://wenny.tloo.cn/indaclub.mp3 Go go go go Go go go shawty It''s your birthday We gon party like it''s yo birthday We gon sip Bacardi like it''s your birthday And you know we don''t give a ** It''s not your birthday Go go go go Go go go !

小甜心，这是你的生日我们聚在一起就象这是你的生日！我们喝百加德就象这是你的生日！你知道其实我们也不在乎这是不是你的生日！

Out where the river broke The bloodwood and the desert oak Holden wrecks and boiling diesels Steam in forty five degrees The time has come To say fair's fair To pay the rent To pay our share The time has come A fact's a fact It belongs to them Let's give it back How can we dance when our earth is turning How do we sleep while our beds are burning How can we dance when our earth is turning How do we sleep while our beds are burning The time has come To say fair's fair To pay the rent, now To pay our share Four wheels scare the cockatoos From Kintore East to Yuendemu The western desert lives and breathes In forty five degrees The time has come To say fair's fair To pay the rent To pay our share The time has come A fact's a fact It belongs to them Let's give it back How can we dance when our earth is turning How do we sleep while our beds are burning How can we dance when our earth is turning How do we sleep while our beds are burning The time has come To say fair's fair To pay the rent, now To pay our share The time has come A fact's a fact It belongs to them Let's give it back How can we dance when our earth is turning How do we sleep while our beds are burning

在哪里爆发的河流该bloodwood和沙漠橡树霍顿沉船和沸腾柴油蒸汽在45度现在时机已到如果说公平公正付房租我们的支付份额现在时机已到一个事实是事实它属于他们让我们回到我们怎么能跳舞时，我们的地球是转折点我们怎么睡觉，而我们的床燃烧我们怎么能跳舞时，我们的地球是转折点我们怎么睡觉，而我们的床燃烧现在时机已到如果说公平公正付房租，现在我们的支付份额四个轮子吓唬cockatoos 从金托尔东Yuendemu 西部沙漠的生命和呼吸在45度现在时机已到如果说公平公正付房租我们的支付份额现在时机已到一个事实是事实它属于他们让我们回到我们怎么能跳舞时，我们的地球是转折点我们怎么睡觉，而我们的床燃烧我们怎么能跳舞时，我们的地球是转折点我们怎么睡觉，而我们的床燃烧现在时机已到如果说公平公正付房租，现在我们的支付份额现在时机已到一个事实是事实它属于他们让我们回到我们怎么能跳舞时，我们的地球是转折点我们怎么睡觉，而我们的床燃烧

An algorithm is developed to differentiate sleep stages with respiration frequency and frequency of leg movements to differentiate sleep into four sleep stages including awake, deep sleep, light sleep and REM.

接著本研究即尝试发展一套判读睡眠阶段演算法，以呼吸频率变异系数和腿部动作频率两项外显行为讯号判读睡眠阶段，能将整晚睡眠区分为清醒、深眠、浅眠、 REM 等四个阶段。

Take em\' to the bridge Dirty babe You see these shackles Baby I\'m your slave I\'ll let you whip me if I misbehave It\'s just that no one makes me feel this way Take em\' to the chorus Come here girl Go ahead, be gone with it Come to the back Go ahead, be gone with it VIP Go ahead, be gone with it Drinks on me Go ahead, be gone with it Let me see what you\'re working with Go ahead, be gone with it Look at those hips Go ahead, be gone with it You make me smile Go ahead, be gone with it Go ahead child Go ahead, be gone with it And get your sexy on Go ahead, be gone with it Get your sexy on Go ahead, be gone with it

请带我去的桥梁肮脏的宝贝你看这些束缚宝贝我的奴隶我会告诉您鞭打我，如果我行为不当这只是没有人让我感到这种方式请带我去合唱团来到这里的女孩来吧，是与它去来到回来吧，是与它去贵宾来吧，是与它去我的饮料来吧，是与它去让我看看你的工作与来吧，是与它去看看那些臀部来吧，是与它去你让我微笑来吧，是与它去来吧孩子来吧，是与它去和你的性感来吧，是与它去让您的性感来吧，是与它去

My baby has been four months earlier he also slept well, since I used a small after him one sleep every night until dawn, there is a 11 o'clock the morning do not want to sleep out, the small approach is a post-natal crosstraining, freeclimber Canal zone, and so he gently fell asleep after his round, pay attention to other tight, because when kids go to bed, they will often吓醒themselves, will give one-handed scare effect, so one night down, certainly woke several times, round him, he will have a sense of security, note that this method is best before noon and evening, and normally he would sleep a little sleep, a moment to wake up on the other by You may wish to try, a lot of people, and that can be.

我孩子已四个月了，前段时间他也睡得不好，自从我用了一个小方法之后，他每晚都一觉到天亮，还有一个睡到早上十一点还不想出来了，这个小方法就是，拿一条产后的收腹带，等他睡着了之后轻轻的把他搂住，注意别太紧，因为宝宝睡觉的时候，自己会经常吓醒自己，一吓两手就会举起，这样一晚下来，肯定醒好几回，搂住他，他会有安全感，注意，这种方法最好在中午和晚上才用，平时他会睡一点小觉，一会儿就醒就别用了，你不防试试，好多人用了，都说可以。

Hanna: That's over now, isn't it?

都结束了，对吗

You must be ill. You look so pale.

你一定是病了，你的脸色苍白。