查询词典 glycocholic

Glycocholic acid is a kind of glycol-conjugated bile acid which exists in many animals'bile. It is one of main component of bile acid and was synthesized from cholalic acid and glycine in liver.

甘氨胆酸是胆汁酸的主要成分之一，属于结合型胆汁酸，在肝脏中由胆酸和甘氨酸结合而成。

The optimum condition was determined via orthogonal experiments, and the result shows that the technology of bile extraction and purification adopts 10L chromato bar with 3L bile, gel silica as fixed phase, the mixed chloroform and isopropanol as mobile phase, gradient elution with mobile phase (the mobile phase ratio in extraction of cholalic acid and glycocholic acid is 4:1 , and then becomes 3:2 in extraction of glycocholic acid and glycocholic acid), and eluting velocity of 3～5mL/s .

采用正交试验筛选了柱层析最佳条件，以容积为10L的层析柱进行分离纯化，固定相为硅胶，流动相为氯仿和正丁醇混合溶剂，一次装样量3000mL胆汁，流动相采用梯度洗脱，先按4：1比例分离胆酸和甘氨胆酸，然后按3：2比例分离甘氨胆酸和牛磺胆酸，流动相洗脱速度为3～5mL/s。

These three kinds of Bile extraction were qualitatively detected by using the paper chromatography and infrared spectral scanning method, and the results show that These extractions have the same Rf value and infrared spectra's characteristic absorption peak as choleic acid, glycocholic acid and taurocholic acid standard preparation which can prove that These three kinds of Bile extraction are choleic acid, glycocholic acid and taurocholic acid respectively.

采用薄层层析法和红外光谱扫描法对提取物进行定性检测，结果证明三种提取样品分别与胆酸、甘氨胆酸及牛磺胆酸标准品显色斑点Rf值相同，红外光谱特征吸收峰均一致，表明提取出的三种样品分别为胆酸、甘氨胆酸、牛磺胆酸结晶体。

The study on the extracting small experiment of Choleic acid, Glycocholic acid and Taurocholic acid.The extracting small experiments of Choleic acid, Glycocholic acid and taurocholic acid were studied by adopting deproteinizatio, depigmentation, extraction and column chromatographic fractionation.

提取胆酸、甘氨胆酸、牛磺胆酸的小试工艺研究采用脱蛋白、除色素、萃取、柱层析分离等方法开展了从牛羊混合胆汁中分离、提取和纯化胆酸、甘氨胆酸及牛磺胆酸三种有效成分的小试提取工艺研究。

Results:Natrium glycocholic acid and natrium glyceric acid had strong accelerating action.

以甘珀酸钠和甘氨胆酸钠为促进剂可制成有效的肺吸入胰岛素气雾剂。

Methods:Six surfactants－bean phospholipid,pulmonary surfactant,rhamnose,imidazoline,natrium glycocholic acid and natrium glyceric acid were chosen as accelerator to made into insulin solutions,and then use tween－80 and span－80 as matrix to made insulin aerosols,which were ultrasounicly nebulized and inhaled by SD rats through nose.

选用豆膦脂、肺表面活性剂、鼠李糖、咪唑啉、甘氨胆酸钠和甘珀酸钠六种表面活性剂为促进剂，制成胰岛素溶液，再以吐温－80、司盘－80做基质制成胰岛素气雾剂，经超声雾化，自SD大鼠鼻腔吸入，分别检测其血糖降低程度。

This method has the convenient,stable, accurate and pragmatic characteristics and is suitable to analyze the glycocholic acid content.

该方法具有简便、稳定、准确、实用的特点，适用于甘氨胆酸含量的分析。

The study on pharmacokinetics of Glycocholic acid in rats Solid extraction -reversed-phase high performance liquid was used to detect the concentration of glycocholic acid in blood serum,liver, kidney and brain tissue in rats.

甘氨胆酸在大鼠体内的药代动力学研究采用固相萃取-反相高效液相色谱法测定了大鼠血清及肝、肾、脑组织中甘氨胆酸的含量。

As the results showed that the significant relation between TCBA and calcium or magnesium, mainly between glycocholic, glycochenocholic or taurocholic acids and calcium or magnesium, could be found in all three groups but there was not any obvious relation between TCBA and ferrum or zinc except between glycocholic acid and zinc in gallbladder stone group.

由此可见前列腺素在胆结石形成中占有重要地位。花生四烯酸是合成前列腺素的前体，它在环氧化酶作用下形成前列腺素。本研究证实在成石性胆囊胆汁中花生四烯酸的含量（0.09%）和阳性率（71.74%）明显高于对照组（0.02%，21.42%），P.05。说明成石性胆汁为合成前列腺素提供了前体物质。

The results manifest that the concentration of glycocholic acid has satisfactory linear correlation whith peak area, regression equation: Y= 39579X + 57823,R2=0.9984;The lowest detected concentration is 0.02μg/mL with S/N=3 ; Average recovery rate is 98.49%; RSD为0.52%～2.00%in day, RSD为0.74%～4.98%between days;The average recovery rate is 99.35%, RSD is 2.24% in the first team, and it is 100.87%, RSD is 4.73% in the second team at the stability test. When the concentration of glycocholic acid was detected in the liver, kidney and brain tissue, corresponding tissue concentration was calculated by preparing the standard curve with the glycocholic acid standard preparation in vitro, but the result can only reflect the relative chang law of the concentration of glycocholic acid in tissue but not in real tissue. The result of tissue stability experiment is consistent with that of the serum experiment.

结果表明，在0.15625～10.0μg/ml范围内血清中甘氨胆酸浓度与峰面积呈良好的线性关系，回归方程Y= 39579X + 57823，R2=0.9984；以信噪比S/N=3为标准，最低检测浓度为0.02μg/ml；平均回收率为98.49%；日内RSD为0.52%～2.00%，日间RSD为0.74%～4.98%；稳定性试验第一组的平均含量为99.35%，RSD为2.24%，第二组的平均含量为100.87%，RSD为4.73%；测定了肝、肾、脑组织中甘氨胆酸含量，采用体外甘氨胆酸标准品制备标准曲线的方法计算了相应的组织浓度，其结果仅反映组织中甘氨胆酸浓度的相对变化规律，不能体现真正的组织浓度值，但对组织样品的稳定性进行了较细致的考察，其结果和血样结果基本一致。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。