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The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

Hey yo jim man why don't ya, you don't you kick some of that you know you know how you do it man it's a trip people don't even believe were together right now but tell your story you know the one i like say it for me riders on the storm riders on the storm into this house we're born (into this house we're born) into this world we're thrown (into this world we're thrown) like a dog without a bone an actor out on loan riders on the storm there's a killer on the road his brain is squirmin' like a toad take a long holiday let your children play if ya give this man a ride sweet family will die killer on the road, yeah goin' off of this off of that with the lizard king bumpin' in the back how bout that driftin', liftin', swiftin', coastin', testaroastin' but the wheels won't stop 200 on the highway fresh up off the block he's a rider, na he's a killer dresses in all black but his hat says stealla pedal to the metal i gotta go hard drive by and say hello hey fredwreck you my mello now let me here what i sound like acapella wow ride dip swish now bring it back just like this like a dog with out his bone unlike a g with out his chrome it's hard to imagine the homey dog in a jag and he's checkin' for the checkered flag comin' in first never in last cause my car to fast i neva eva run out of gas cause i just to clean i do it upper class so fasten your seat belts its so hot it will even make heat melt so get a bowl and roll and ride slip through the slip and slide like a dog without a bone an actor out on loan riders on the storm there's a killer on the road his brain is squirmin' like a toad take a long holiday let your children play if ya give this man a ride sweet family will die killer on the road, yeah need for speed i'm trying to take the lead hold on little homey before you run into the trees i've seen thinks that i would have never saw before hey yo jim let'em in, let'em in open up my back tire smokin' the whole street and now the police wanna flash there lights and chase the dogg all night but i won't pull over nor give up cause i just don't give a fuck yeah from the side boy where we was born and raised straight up to ride boy continuously, we get to an expeditiously keep the light on east side on snoop dogg and the doors and yeah we bout to ride on riders on the storm riders on the storm into this house we're born into this world we're thrown were thrown

嘿摇摇弯轨机人为什么不唉，你不你踢一些那你知道你知道如何你这样做人这是一次旅行人们甚至不相信是在一起此时但告诉你的故事你知道那个我像为我说它骑士在暴风雨上骑士在暴风雨上入这房子我们是出生入这世界我们是扔像个狗没有一根骨头一个演员那儿有一个杀手在路上他的大脑是squirmin'像个癞蛤蟆采取一个长的假期让你的孩子们玩如果唉给这人一个乘甜家将死凶手在路上，是呀去'离开对于这离开关于那和蜥蜴国王 bumpin'在后面如何拳击比赛那 driftin'，liftin'，swiftin'，coastin'，testaroastin'但是这个车轮不会停止两百在公路上新鲜向上远离块他的一个骑士，娜他的一个杀手衣服在纯黑但他的帽子说stealla 踩踏板金属我有去难驶过和问好嘿fredwreck 你我的梅洛现在让我这里什么我听起来像acapella 哇骑现在倾斜豪华带来它回来只是这样像个狗与出来像个狗没有一根骨头一演员借出的骑士在暴风雨上那儿有一个杀手在路上他的大脑是squirmin'像个癞蛤蟆采取一个长的假期让你的孩子们玩如果唉给这人一个乘甜家将死凶手在路上，是呀需要速度我是试图着先鞭继续小像家一样在你未碰撞树木我已经看到想那我从来不锯在以前嘿摇摇弯轨机让'em 在，让'em 在开发我的后面疲劳smokin'一街一巷那么警察要闪光那儿灯光和追逐道格整夜但我不会拦截也不放弃造成我只是不给一个性交是呀自边男孩我们在那里出生和提升直直至骑男孩骑士在暴风雨上骑士在暴风雨上入这房子我们是出生入这世界我们是扔我的翻译不太标准别见怪

Cause girl I've never been more sure (that baby, it's you) This ring here represents my heart And everything that you've been waiting for (just say "I do") Yeah, because I can see us holding hands Walking on the beach, our toes in the sand I can see us on the countryside Sitting on the grass, laying side by side You could be my baby, let me make you my lady Girl, you amaze me Ain't gotta do nothing crazy See, all I want you to do is be my love (So don't give away) My love (So don't give away) My love (So don't give away) Ain't another woman that can take your spot, my love (So don't give away) My love (So don't give away) My love (So don't give away) Ain't another woman that can take your spot, my love Ooooh, girl My love My love Shorty, cool as a fan On the new once again Still has fan from Peru to Japan Listen baby, I don't wanna ruin your plan If you got a man, try to lose him if you can Cause your girls real wild through your hands up high Wanna come kick it wit a stand up guy You don't really wanna let the chance go by Because you ain't been seen wit a man so fly Friend so fly i can go fly Private, cause I handle mine Call me candle guy, simply because I am on fire I hate to have to cancel my vacation so you can't deny I'm patient, but I ain't gonna try You don't come, I ain't gonna die Hold up, what you mean, you can't go why?

我和你男朋友我们不不是领带当我不是的时候，你说你 wanna 踢它如此高度好吧，宝贝我不是你的家伙是明显的不是 gon'谎言，我感觉你的空间但是忘记你的脸，我发誓我意志相同的标志，无论何处的相同子弹我寒冷仅仅带给机智我双，我意志我能看见我们把持手海滩上的步行，沙子的我们足趾我能在乡下地方之上看见我们草上的就坐，并排放置你可能是我的宝贝，让我使你成为我的淑女少女，你使吃惊我不是必须什麽也不做发狂的看见，我想要你做的全部是我的爱我的爱我的爱不是能带你的地点，我的爱另外的一个女人我的爱我的爱不是能带你的地点，我的爱另外的一个女人 Ooooh，少女我的爱我的爱

She is not in the washroom and then stopping, because it is finally his own point of view that he cares about and not hers, and with this firmly in mind, and a light, confident step, such as you might find in the works of Bulwer-Lytton, he enters the space she occupies so prettily and, taking her by the hand, proceeds to tear off the stiff white hospital gown (but no, we cannot have that kind of pornographic merde in this majestic and high-minded sentence, which will probably end up in the Library of Congress)(that was just something that took place inside his consciousness, as he looked at her, and since we know that consciousness is always consciousness of something, she is not entirely without responsibility in the matter) so, then, taking her by the hand, he falls into the stupendous white puree of her abyss, no, I mean rather that he asks her how long it has been since her last visit, and she says a fortnight, and he shudders, and tells her that with a condition like hers (she is an immensely popular soldier, and her troops win all their battles by pretending to be forests, the enemy discovering, at the last moment, that those trees they have eaten their lunch under have eyes and swords)(which reminds me of the performance, in 1845, of Robert-Houdin, called The Fantastic Orange Tree, wherein Robert-Houdin borrowed a lady's handkerchief, rubbed it between his hands and passed it into the center of an egg, after which he passed the egg into the center of a lemon, after which he passed the lemon into the center of an orange, then pressed the orange between his hands, making it smaller and smaller, until only a powder remained, whereupon he asked for a small potted orange tree and sprinkled the powder thereupon, upon which the tree burst into blossom, the blossoms turning into oranges, the oranges turning into butterflies, and the butterflies turning into beautiful young ladies, who then married members of the audience), a condition so damaging to real-time social intercourse of any kind, the best thing she can do is give up, and lay down her arms, and he will lie down in them, and together they will permit themselves a bit of the old slap and tickle, she wearing only her Mr.

然后阻止，因为到最后那是他自己的关心的观点而不是她的，在他的脑子里根深蒂固，他自信地走了一步，这就像你也许会在布尔沃？里顿的作品中看到的一样，他进入兴高采烈地进入她占有的空间，抓住她的手，开始撕开他白色僵直的病号衣（但是我们没有在他冠冕堂皇的充满智慧的语句中发现那种带有色情的废话，那也许会在国会图书馆中绝迹）（在他的意识中有一些东西正在被替代，当他看她的时候，就如我们知道的意识始终是意识，她在这个事情中不是完全没有责任的），所以，然后抓起她的手，他掉进了她深渊的巨大白色水中，不，我想他问她自从她上回来已经多久了，她说有两个星期了，他战栗着告诉她她现在的情况（她是一个非常受欢迎的女兵，她的部队通过埋伏在森林里赢得了所有的战斗，在最后的时刻敌人发现了，那些他们吃掉他们午餐的树有了眼睛和剑）（这使我想起了一八四五年罗伯特？乌丹的演出，叫做《奇幻橘子树》，在其中罗伯特？

She is not in the washroom and then stopping, because it is finally his own point of view that he cares about and not hers, and with this firmly in mind, and a light, confident step, such as you might find in the works of Bulwer-Lytton, he enters the space she occupies so prettily and, taking her by the hand, proceeds to tear off the stiff white hospital gown (but no, we cannot h39e that kind of pornographic merde in this majestic and high-minded sentence, which will probably end up in the Library of Congress)(that was just something that took place inside his consciousness, as he looked at her, and since we know that consciousness is always consciousness of something, she is not entirely without responsibility in the matter) so, then, taking her by the hand, he falls into the stupendous white puree of her abyss, no, I mean rather that he asks her how long it has been since her last visit, and she says a fortnight, and he shudders, and tells her that with a condition like hers (she is an immensely popular soldier, and her troops win all their battles by pretending to be forests, the enemy discovering, at the last moment, that those trees they h39e eaten their lunch under h39e eyes and swords)(which reminds me of the performance, in 1845, of Robert-Houdin, called The Fantastic Orange Tree, wherein Robert-Houdin borrowed a lady's handkerchief, rubbed it between his hands and passed it into the center of an egg, after which he passed the egg into the center of a lemon, after which he passed the lemon into the center of an orange, then pressed the orange between his hands, making it 56aller and 56aller, until only a powder remained, whereupon he asked for a 56all potted orange tree and sprinkled the powder thereupon, upon which the tree burst into blossom, the blossoms turning into oranges, the oranges turning into butterflies, and the butterflies turning into beautiful young ladies, who then married members of the audience), a condition so damaging to real-time social intercourse of any kind, the best thing she can do is give up, and lay down her arms, and he will lie down in them, and together they will permit themselves a bit of the old slap and tickle, she wearing only her Mr.

然后阻止，因为到最后那是他自己的关心的观点而不是她的，在他的脑子里根深蒂固，他自信地走了一步，这就像你也许会在布尔沃？里顿的作品中看到的一样，他进入兴高采烈地进入她占有的空间，抓住她的手，开始撕开他白色僵直的病号衣（但是我们没有在他冠冕堂皇的充满智慧的语句中发现那种带有色情的废话，那也许会在国会图书馆中绝迹）（在他的意识中有一些东西正在被替代，当他看她的时候，就如我们知道的意识始终是意识，她在这个事情中不是完全没有责任的），所以，然后抓起她的手，他掉进了她深渊的巨大白色水中，不，我想他问她自从她上回来已经多久了，她说有两个星期了，他战栗着告诉她她现在的情况（她是一个非常受欢迎的女兵，她的部队通过埋伏在森林里赢得了所有的战斗，在最后的时刻敌人发现了，那些他们吃掉他们午餐的树有了眼睛和剑）（这使我想起了一八四五年罗伯特？乌丹的演出，叫做《奇幻橘子树》，在其中罗伯特？

It is Red Nation and Grand Master nature to give of oneself; give ones' love away; give give give.

送出正是红族人或者大师的天性，他们不断将自己送出、不断将爱送出、不断送出送出送出。

Good times 打印此页歌手:eddie brickel Eddie Brickell Good Times You don't even have to try It comes easy for you The way you move is so appealing It could make me cry Go out driving with my friends In Bobby's big old beat up car I'm with a lot of people then I wonder where you are Good times, bad times, give me some of that Good times, bad times, give me some of that I don't want to say goodbye Don't want to walk you to the door I spend a little time with you I want a little more Good times, bad times, give me some of that Good times, bad times, give me some of that Good times, bad times, give me some of that

繁荣时期你不需要去试它将简单的向你冲来这种你移动的方法是多么吸引人它将使我哭和我朋友一起出去开车在Bobby的打的破车中我领先与许多人之后我想知道你在哪繁荣时期，不繁荣时期，给我一些那个我不想说再见不想走向你的门我花一些时间和你我想要更多的时间繁荣时期，不繁荣时期，给我一些那个繁荣时期，不繁荣时期，给我一些那个繁荣时期，不繁荣时期，给我一些那个

Because lecturer Wang always saying it recently, should sublease the apartment with us, and I call him uncle Wang according to the courtesy , focal point even if I want classics of watching, I extraordinary fearness household noisy, household noisy I nothing hear right away, so I must depend on Triratna, because the uncle Wang he become a Buddhist at all, what he believes is the Triratna that is always said, explain Buddha dharma to him, he will talk about the similar law that they always said, so really make me too bitter to say, certainly I know this it is hindered that is my family property, if miss obstacle, must learn to give up, that is to say that gives up one's own moral integrity , certainly perhaps a lot of people can not understand , in fact very simple , a reason for my meaning, what the string is fastenned is too tight, very apt to lose brokenly, the ones that fastenned are too too loose to spring the sound, so adjust just now very all right, what I say certainly it gives up to be Buddha Bodhisattva in the degrees of all living creature, can give up heads with the brain , certainly if you meet the greedy person , or ignorant person, the left eye of your charity, he wants the right eye, you are two holes of charity, even if he throws your eyes to the ground to step on rottenly , it is so discredited that will blurt out and scold and say, so say that you know , cross all living creature's thing , it is not really what common people can do in this, so I must have pieces of view think meet as me wholehearted to ask people of law , I willing charity everything certainly, but if the other side does not ask the law wholeheartedly , certainly the charity that I can not be silly and silly, I must do the view with reason , it is all right that I act dumb with him, that is to say that he acts dumb with me in meaning, I certainly can regard oneself as noble-minded and unwilling to swim with the tide too, Buddha Bodhisattva is it cross some three evil all living creature of dish to want sometimes, must put down the figure , go to put into animal's body , then go to follow the statement of one of three evil , the focal point is that I am not so great, I do the part of Theravada well first , or finish humanity first, ten is it do five exhortation well to good at first, three Ban 5 exhortation make and discuss well that Bodhisattva has feet to give up to give up, three Ban five exhortation finish anyway, you is it defend the doctrine god defend , so I it hopes to be too urgent what oneself force to have, I am only relaxed studies Buddha.

最近因为一贯道的王讲师，要跟我们分租公寓，而我也是依照礼数称他王叔叔，重点就是我要看经典，我非常的怕人家吵，人家一吵我就什麼也听不到，因此我必须要依靠三宝，因为这位王叔叔他根本没有皈依三宝，他所信的是一贯道的三宝，跟他讲佛法，他都会讲到他们一贯道的相似法，因此真的让我有苦说不出，当然我也知道这都是我的业障，如果不想被障碍，就必须要学会舍，也就是说舍掉自己的德行，当然我的意思可能很多人会听不懂，其实很简单，就是一个道理，弦旋的太紧，很容易断掉，旋的太松会弹不出声音，因此就是调的刚刚好就好，当然我所说的舍就是佛菩萨度众生的时候，可以舍掉头目随脑，当然如果你遇到贪心的人，或者愚昧无知的人，你布施左眼，他要右眼，你两眼都布施，他就是把你的眼睛丢到地上踩烂，还会随口骂说这麼臭，所以说这你才知道，渡众生这一件事情，真的不是一般人可以办到的，因此我必须要有个观想，当我遇到真心求法的人，我当然愿意布施一切，但是如果对方不是真心求法，当然我不可能傻傻的布施，我必须要随缘做观，我跟他装傻就好，意思就是说他跟我装傻，当然我就是不能太自命清高，有时候佛菩萨要渡一些三恶道的众生，都必须要放下身段，去投入畜生身，然后去跟三恶道的说法，重点就是我没有那麼伟大，我先把小乘的部分给做好，或者先把人道做好，先把五戒十善做好，三皈五戒做好再谈菩萨戒具足戒，反正三皈五戒做好，你就会有护法神守护，因此我不希望把自己逼的太紧，我只要轻松的学佛。

The latter is chlorinated in the side chains under free-radical conditions to give 2,4-dichloro-5-fluoro-3-dichloromethyl-1-trichloromethylbenzene. The latter is hydrolysed via 2,4-dichloro-5-fluoro-3-dichloromethylbenzoic acid, which can be isolated if necessary, to give 2,4-dichloro-5-fluoro-3-formyl-benzoic acid, the aldehyde group of which is reacted to give 2,4-dichloro-5-fluoro-3-N-hydroxyiminomethyl-benzoic acid, from which, with simultaneous conversion of the carboxyl group into the chlorocarbonyl group, water is eliminated using an acid chloride to give the nitrile 2,4-dichloro-3-cyano-5-fluoro-benzoyl chloride.

随后，在游离基条件下进行侧链的氯化，得到2，4-二氯-5-氟-3-二氯甲基-1-三氯甲基苯、后者被水解，经过2，4-二氯-5-氟-3-二氯甲基苯甲酸(如果需要此化合物可以分离)，得到2，4-二氯-5-氟-3-甲酰苯甲酸，将其醛基反应，得到2，4-二氯-5-氟-3-N-羟基亚氨基甲基苯甲酸，用酰氯从其中除去水，同时将羧基转化为碳酰氯，得到一种腈，即2，4-二氯-3-氰基-5-氯-苯甲酰氯。

On the other hand, beautiful thoughts of all kinds crystallize into habits of grace and kindliness, which solidify into genial and sunny circumstances; thoughts of courage, self-reliance, and decision crystallize into manly habits, which solidify into circumstances of success, plenty, and freedom; gentle and forgiving thoughts crystallize into habits of gentleness, which solidify into protective and preservative circumstances; loving and unselfish thoughts crystallize into habits of self-forgetfulness for others, which solidify into circumstances of sure and abiding prosperity and true riches.

截然相反的是，各种美好的思想会转变成坚强的习惯，它们会促成充满欢乐的环境；勇敢，自信与果断的思想会转变成坚强的习惯，它们会巩固充满成功，富足与自由的环境；文雅，宽大的思想会转变成温和的习惯，它们能进一步推进安全的，有保障的环境；充满爱心的，慷慨的思想转变成无私的习惯，它们会形成稳定，繁荣，真正富足的环境。——摘自《痛苦是错误思想的结果》詹姆斯。艾伦

The circulation, consumption and reproduction of the trilogy have not only testified to its historical significance and literariness, but also invested it with new meanings.

该三部曲的流通、消费与再生产不仅验证了其历史意义及文学性，而切还赋予它以新的意义。

If he thought that he could buy me off, he would be wrong.

如果他认为他可以收买我，那他就大错特错了。