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Research Center for Genomic Medicine, Department of Radiobiology,School of Public Health, Jilin University, Changchun 130021,China

吉林大学基因组医学研究中心吉林大学公共卫生学院放射生物学教研室,吉林长春130021

Research Center of Genomic Medicine, MH Radiobiology Research Unit, School of Public Health, Jilin Univesity, Changchun 130021,China

吉林大学公共卫生学院基因组医学研究中心卫生部放射生物学重点实验室,吉林长春 130021

The new project will involve a transdisciplinary team of immunologists, allergy physicians, otorhinolaryngology surgeons, and genomic scientists.

这个新项目将需要一个由免疫学家、变态反应医师、耳鼻咽喉外科医师和基因组科学家组成的跨学科的研究团队。

The new project will inole a transdisciplinary team of immunologists, allergy physicians, otorhinolaryngology surgeons, and genomic scientists.

这个新项目将需要一个由免疫学家、变态反应医师、耳鼻咽喉外科医师和基因组科学家组成的跨学科的研究团队。

Objective To detect the methylation levels of genomic DNA in patients with systemic lupus erythematosus.

目的:检测系统性红斑狼疮患者基因组DNA甲基化的水平,探讨其在SLE发病中的意义。

Multiple genetic changes have been found in ESCC,but little is known about major oncogenes and tumor suppressor genes involved in this disease.To surveying chromosome imbalances in this disease,we analyzed statistically high-frequency chromosomal changes of ESCC from the previous studies by multicolour fluorescence in situ hybridization and comparative genomic hybridization.

为鉴定与食管癌关系密切的基因,本研究从染色体畸变的角度出发,在实验室前期工作及相关文献的基础上,统计分析食管癌染色体畸变谱,发现3、5、8号染色体重排及着丝粒断裂再重组可能是最常见的结构改变,3q、8q增益是最常见的数目异常。

The algorithm is based on a data structure that holds in RAM the index of the genomic positions of 'seed' words (typically 11 and 12 bases) as well as an index of the precomputed scores of short words (typically seven and eight bases) aligned against each other.

该算法是基于内存中容纳的&种子&词(通常11和12碱基)的基因组位置的索引,及互相比对的短词(通常7和8碱基)的预先计算的值的一个数据结构。

After building the genomic index, the program scans every query sequence performing three steps:(1) it finds matching seed words in the genome;(2) for every match checks the precomputed alignment of the short flanking regions;(3) if passes step 2, then it performs an exact dynamic alignment of a narrow region around the match.

构建完基因组索引后,程序扫描每个查询序列,运行3个步骤:(1)在基因组中发现匹配的种子词;(2)对于每个匹配,检查短片段的两边区域的预先计算的比对;(3)若满足步骤2,然后围绕匹配运行一个窄区域的精确的动态比对。

The work, reported in the 12 December issue of Science ,"is a valuable start to the genomic approach to identify 'humanness,'" says Ajit Varki, a glycobiologist at the University of California, San Diego, who adds that comparing human and chimp genes to the genome of a closer relative than mice, such as another great ape, would reveal even more genes that defined the branches of the primate family tree.

这项研究发表在12月12日期的《Science》上,是通过基因组学方法识别&人性&的重要起点,加州大学圣地亚哥分校的生物学家Ajit Varki称赞道。他补充说,将人类和黑猩猩的基因与比小鼠亲缘关系更近的物种的基因组进行比较,如另一种类人猿,将会揭示更多定义灵长类进化树分支的基因。

The research region focus on the genomic sequencing, disease genomics, functional genomics, bioinformatics.

其主要研究领域是基因组测序,疾病基因组,功能基因组和生物信息学。

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