查询词典 genetic disease

On this basis, according to historical data, apply ANN and differential simulation method to get the quantitatively correlative relations between each production and its own influence factors, and introduce the new methods of prediction for dynamic indexes with gas-field development (The combinatorial prediction method based on fuzzy comprehensive evaluation, the method of ANN to select optimally combinatorial prediction models and the ANN prediction method based on genetic algorithm).(2) Base on mathematical programming, combine with quantitative economics and techno-economics, introduce economical indexes to establish production"s distribution optimal model, production"s constitution optimal model and measured production"s constitution optimal model, including multi-objective models and five-years models. Upon this, the optimal project for all gas field and each gas-collected factory can be got. Also, introduce the time value of capitals to improve on these models.(3) Base on the optimal solution theory and algorithm theory for the nonlinear programming problem, introduce the SUMT algorithm and genetic algorithm to study how to solve the models, and on the basis of normal genetic algorithm, make use of auto-adaptively modulating method to improve on normal genetic algorithm; Base on algorithm"s convergence theory and calculation"s complexity theory to analyze seriatim SUMT algorithm"s convergence and genetic algorithms convergence, and compare performance with each other.

在此基础上，利用神经网络方法和微分模拟方法根据历史数据得到各分项产量与其影响因素之间的定量关联关系，并引入气田开发动态指标新的预测方法(基于模糊综合评判的组合预测方法、神经网络优选组合预测模型预测方法以及基于遗传优化的神经网络预测方法)；(2)以数学规划为基础，结合数量经济学和技术经济学，引入经济指标建立产量分配优化模型、产量构成优化模型、措施产量构成优化模型、气田开发多目标规划模型以及五年规划模型，进而获得全气田及各采气厂的最优方案，并引入资金时间价值对五年规划模型进行改进；(3)以非线性规划问题的最优解及算法理论为基础，引入SUMT算法以及遗传算法对模型的求解进行研究，并在原有的遗传算法基础上，引入自适应调整方法对遗传算法进行改进；以算法的收敛性理论和计算复杂性理论为基础，逐一分析SUMT算法以及遗传算法的收敛性，并比较三种算法的优劣性。

The 54 accessions were classified into five major groups:Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ by cluster analysis using UPGMA, which showed significant relationship with the origin regions of accessions. Genetic differentiation between and within eight eco-geographical groups of C.dactylon was estimated by Shannon's diversity index, which showed that 63.81% genetic variance existed within group, and 36.19 % genetic variance was among groups, indicating rather large genetic distances among those germplasm, and there was a correlation between genetic differentiation and eco-geographical habits among the groups.

聚类分析结果表明，52份材料可聚为5类；基于Shannon多样性指数估算了8个狗牙根生态地理类群内和类群间的遗传分化，类群内的遗传变异占总变异的63.81%，类群间的遗传变异占总变异的36.19%，表明这些抗源材料遗传差异较大，各生态地理类群间的遗传分化与其所处的生态地理环境具有一定的相关性。

Moreover, the actual allele frequency of most varieties deviates far from Hardy-Weinberg equilibrium. All PPB、na 、I、h、Gi and Fst have proved to be the references to elucidate that ISSR is a most powerful tool to analyze genetic diversity, compared with the RAPD marker and the allozyme marker is less strong ordinally. We could divided the 70 samples into A, B, C, D and E five groups using three methods according to genetic distance clustering. There is a bit displacement for few varieties in different clustering maps, but the most are similar to morphological analysis despite that there is still a great difference among cultivars in the same one group. The above results imply that the three methods have the different sensitivity and resolution in genetic distance analysis of close varieties. The Mantel test indicates that the results from the three kinds of markers have the significant correlation, which demonstrates that the number of the used three kinds of markers is enough to exactly detect the diversity of all 70 samples to ideal extent. And these methods can be used to evaluate the diversity of the whole group using the miscellaneous samples instead of the individual sample, of the Gerbera jamesonii are mainly from tissue culture plants. In conclusion, the above study results provide a reference for the application of three kinds of molecular markers to molecular marker-assisted breeding of flower. 2. The genetic diversity among the eight introduced cut-flower varieties of Ranunculus asiatica was analyzed by the ISSR markers. Based on the genetic clustering tree, all the colorful flower varieties are clustered into one group, and the white flower varieties into another group. Moreover, among the former group the yellow flower varieties are clustered into one sub-group, and the reddish flower varieties, such as rose color, pink, nacarat, are clusetered into another sub-group.

由三种分子标记的分析结果可以看出，等位基因平均值、观察杂合度、Fis值、Fit值皆较高，表明非洲菊等位基因较丰富，杂合基因偏多，且绝大部份品种的实际等位基因频率在品种内偏离了Hardy-Weinberg equilibrium；PP8、na、Ⅰ、h、Gi及Fst皆表明，ISSR检测遗传多样性的能力最强，其次是RAPD，等位酶最低；根据遗传距离进行聚类，三种方法都把70个品种分成A、B、C、D、E五个大组，每一组中除少数品种发生位移外，大部份品种分类结果相似，且与形态分析结果有相似性，但在每一组中，品种间的聚类差别较大，表明这三种方法在近距离品种间检测遗传变异时灵敏度及分辨力不同；Mantel检测表明，三种标记的分析结果有显著相关性，表明所用的三种分子方法的标记数量已经可以相对无偏地检测到70个品种间遗传变异；非洲菊为组培苗，三种标记的检测结果皆表明，混合样品可以作为个体样品的代表，对整个居群的遗传多样性进行评价；这些研究结果可为三种分子标记方法在花卉分子辅助育种中的进一步应用提供借鉴。

In this study, genetic analyses were conducted to determine the genetic basis in an elite resistant inbred line Siyi with complete resistance to maize dwarf mosaic. A new genetic model, two dominant complementary genes conditioning the resistance, were found by Mendelian genetic analysis based on parents, F1, F2 and backcrosses in three successive years' field trails. The two genes were further mapped near the centromere of chromosome 3 and 6, respectively by tightly linked microsatellite markers using 242 plants from F2 generation. The resistance gene on chromosome 3 is 1.0 cM apart from the flanking markers phi053 and umc1527, respectively. Whereas the linkage distance between two flanking markers bnlg1600 and phi075 and resistance gene on chromosome 6 was 1.0 and 4.0 cM, respectively. Genotypic analysis of the plants from testcross and F3 populations supported the new genetic manners.

课题组通过连续三年的抗病鉴定，在国内种质资源中筛选出一份综合农艺性状优良、配合力较高的自交系四一，三年的表型遗传研究和两年的分子标记工作，发现四一中的玉米矮花叶病抗性是由两对显性互补基因控制的，进而利用F2作图群体，把发现的两个基因定位在第三和第六染色体的着丝点附近，并获得了双侧紧密连锁的分子标记连锁图谱，其中第三染色体上的分子标记UMC1527和phi053从抗病基因双侧逼近1 cM，而第六染色体上的分子标记phi075、bnlg1600从抗病基因双侧分别逼近4 cM和1 cM；利用B2群体、F2：3家系、BC3F1群体和带有第三、第六染色体抗病基因以及两个抗病基因的近等基因系，进一步证实了四一中成株期抗性是由两个显性互补基因控制的。

ABSTRACT It is because that the excellent acceptors for maize transgenic engineering are insufficient in our country, especially in the southwest mountain areas of china and hereditary variation regularity for the two characters such as efficiency of embryonic callus induction and number of regenerating plant (these two characters were abbreviated to the nduction efficiency and number of regenerating in the following of the paper, respectively), which hint the maize culturing capacity, is not very clear. Therefore, aiming at picking out superior acceptors, we had made systematic researches on the two characters with combing traditional quantitative-character genetic analyzing methods such as single-factor genetic mating design, diallel crossing genetic design, genetic effect analyzing method and the modern molecular locating method such as QTLs'. The main results are followed.(1) 50 superior inbred lines and about 30 crosses in our country, especially in the southwest of China were used for identifying and selecting the superior genotypes in the above two investigated characters under the same culturing condition in 2000 and 2001. There was very significant difference among the genotypes in the both characters. But the two characters were not certainly related. Some genotypes such as 18-599 and 18-599 were very good in them. For some ones such as zong 31, induction was higher than 18-599 and 18-599 in the efficiency, but it was only 1/3 to the later in regenerating number. In some genotypes such as S37, R08, R15, P138, A318, induction efficiency was just about 3% and scarcely any regenerating plants were got. On the whole, hybrids acted better than inbreeds in the both characters.(2) Two kind of inbreeds were selected as parents of the Griffing's method 1. 18-599 and 18-599 and the inbred line zong 31 are one kind because they are not only superior in the characters of maize cross breeding, such as CA, resistance to disease and the important agricultural characters, but also excellent in transformation characters as the induction and regeneration.

针对我国、特别是西南山地所需玉米转基因工程育种优良受体极为匮乏和反应玉米幼胚培养能力的2个主要性状，即玉米幼胚胚性愈伤组织诱导率和胚性愈伤组织绿苗发生数的遗传变异规律十分不清楚的实际情况，本研究从筛选玉米转基因工程所需要的优良受体入手，采用单因素遗传交配设计、双列杂交遗传交配设计、世代基因效应等传统数量性状分析方法，以及现代分子标记定位主效QTL分析方法，对玉米幼胚胚性愈伤组织诱导率和胚性愈伤组织绿苗发生数等2个性状进行了较为系统的分析研究，取得以下主要研究结果：(1)于2000年和2001年通过对我国、特别是西南地区近50份优良自交系和近30个杂交组合，在相同培养条件下，对幼胚培养胚性愈伤组织诱导率和胚性愈伤组织绿苗发生数等2个幼胚培养能力性状进行了筛选与鉴定，发现玉米不同基因型具有完全不同的幼胚培养胚性愈伤组织诱导率和胚性愈伤组织绿苗发生数，但幼胚培养胚性愈伤组织诱导率与胚性愈伤组织绿苗发生数并不具有必然的相关关系，有的基因型，如自交系18-599和18-599在胚性愈伤组织诱导率和愈伤组织绿苗发生数等2个性状都表现相当优异；有的基因型，如自交系综31，仅幼胚培养胚性愈伤组织诱导率性状表现高于19-599和18-599，但在胚性愈伤组织绿苗发生数这一性状则与它们有相当大的差距，仅为19-599和18-599的1/3左右；有的基因型，如S37、R08、R15、P138、A318等玉米自交系不仅幼胚培养胚性愈伤组织诱导率很低，平均仅在3％左右，而且胚性愈伤组织绿苗发生数表现也很差，基本上没有分化成苗。

This book in all 126 chapters, content involves cardiovascular disease foundation, not have achieve video learn, disease of valve of physiological, heart, aorta mixes report outside element of risk of week blood-vessel disease, coronary artery disease, cardiac muscle straightens dead, disease of heart and pericardium and pulmonary circulation disease, cardiac muscle and heart failure,, include 1400 plans, among them 483 are chromophotograph, kinetic draw writes down the radiative a collection of illustrative plates that covers electric physiology draw to write down image of graph, angiography, heart to be short of caustic and blood stream the graph.

该书共126章，内容涉及心血管疾病基础、无创影像学、电生理学、心脏瓣膜病、主动脉和外周血管疾病、冠状动脉疾病危险因素、心肌梗死、心脏和心包以及肺循环疾病、心肌病和心力衰竭、心脏药理学、有创及介入心脏病学等11个部分，包括1400幅图，其中483幅为彩色照片，涵盖电生理描记图、血管造影图像、心脏缺损的放射图谱以及血流动力学描记图等。

Above all, buffalo is degree of a kind of seed selection is planted relative to inferior cultivate, have stronger vitality, disease-resistant force and be able to bear or endure the ability of thick raise, from development degree taller Italy arrives the less-developed country with development inferior degree, on the history, buffalo is done not have or had fed the feed of animal source sex such as pink of flesh and blood, fish meal without raise almost, straight so far, the whole world returns the report of disease of mad without a buffalo happening ox or urticant disease, be like mad ox disease, urticant disease, avian flu, Aibola disease to wait for harm mankind health in more and more animal sex diseases today, we can say, buffalo still is a god-given Sukhavati; so far next, the gust of water milk and its nutrition character have other to suckle kind of dominant position that cannot compare, an orgnaization of England undertook grandma of water milk, grandma milk, goat and artificial synthesis are suckled savour an experiment, via repeating for many times, join the person that try to be able to accurate winkle buffalo is suckled and state they are right the partial; of its gust the 3rd, as the addition of global population and the growth that suckle kind of consumption group, allergic to milk number also rises ceaselessly, but have to suckling milk.

首先，水牛是一种选育程度相对较低的畜种，具有较强的生命力、抗病力和耐粗饲的能力，从开发程度较高的意大利到开发程度较低的欠发达国家，在历史上，水牛就没有或几乎没有饲喂过骨肉粉、鱼粉等动物源性饲料，直到目前为止，全世界还没有一例水牛发生疯牛病或痒病的报道，在越来越多的动物性疾病如疯牛病、痒病、禽流感、埃博拉病等危害人类健康的今天，我们可以说，水牛到目前为止仍是一块难得的净土；其次，水牛奶的风味及其营养特性具有其它奶类不可比拟的优势，英国的一个机构进行了一次水牛奶、奶牛奶、山羊奶和人工合成奶的品味试验，经多次重复，参试者都能准确的挑出水牛奶并表示他们对其风味的偏爱；第三，随着全球人口的增加和奶类消费群体的增长，对牛奶过敏的人数也不断增长，但对奶牛奶有。。。

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这次公告的40家网站具体包括中国医科大学附属不孕不育研究中心(www.2008sbb.com/)销售麒瑞孕宝胶囊和麒瑞生精胶囊，声称治疗不孕不育；亚太生殖医学研究中心(www.999qlx.com/)销售纳米前列肽胶囊，声称治疗男性疾病；中国中医高等医学研究院色斑专研中心(www.seban886.com)销售强效祛斑胶囊，声称治疗色斑；中国乙肝防治救助工程办公室(www.gegd.com.cn/)销售乙肝灵浓缩丸，声称治疗乙肝；中华国际皮肤病研究院银屑病康复中心(www.000120.com/)销售金蟾·癣肽，声称治疗皮肤病；中国国际皮肤病基因研究院牛皮癣研究中心(www.gjpf.com/)销售益肾祛屑宁，声称治疗皮肤病；中研国际医药科学专研总院糖尿病治疗中心(www.tnb518.com/)销售珍宝糖胰宁，声称治疗糖尿病；国际心脑血管病研究总会中国高血压病研究中心(www.120gxy.cn/)销售稳压固本丸，声称治疗高血压；中国中医药骨病工程科研院(www.zky666.com/)销售强力归龙筋骨丹，声称治疗强直性脊柱炎等。

The range of mental disease is very wide, include implement qualitative sex disease, if old age is gawkish, much,move paralysis of disease, head to wait, and functional sex disease, like angst disease, depressed disease, schizophrenia, wait into addiction.

精神疾病的范围很广，包括器质性疾病，如老年痴呆、多动症、脑瘫等，以及功能性疾病，如焦虑症、抑郁症、精神分裂症、成瘾等。

Among all persons who finished questionnaire 21.68% were resident physician,36.95% were attending physician, 25.65% were vice chief physician/chief physician; the most common cardiovascular disease in the investigated persons hospitals were angina (55.42%),stroke(38.17%), myocardial infarction(28.70%), heart failure (28.24%), hypertension (28.24%); as for early vascular disease detection methods,57.40% of investigated persons thought artery endothelial function examination,46.72% thought angiography, pulse wave velocity measurement and carotid intima-media thickness measurement were 40.61% and 31.76%;76.49% and 53.89% of the investigated persons thought angiotension converting enzyme inhibitor and statins could revert early vascular disease;96.79% of the investigated persons thought promotion early vascular disease detection strategy could help for reducing total burden of cardiovascular disease in our country;78.47% of the investigated persons thought early vascular disease detection methods should be easily used and non-invasive.

被调查者所在医院最常见心血管疾病顺序分别心绞痛55.42%，脑卒中38.17%，心肌梗死28.70%，心力衰竭28.24%，高血压28.24%；关于血管病变早期检测57.40%的被调查者认为通过动脉内皮功能测定，认为通过血管造影者占46.72%，认为通过脉搏波速度和颈动脉内膜中层厚度测定者分别占40.61%和31.76%；分别有76.49%和53.89%的被调查人群认为血管紧张素转换酶抑制剂和他汀类药物能够逆转早期血管病变；96.79%的被调查者认为推广血管病变早期检测技术有利于降低我国心脑血管疾病总体负担；78.47%的被调查者认为用于推广的早期血管病变检测技术应该是操作方便和无创伤。

The circulation, consumption and reproduction of the trilogy have not only testified to its historical significance and literariness, but also invested it with new meanings.

该三部曲的流通、消费与再生产不仅验证了其历史意义及文学性，而切还赋予它以新的意义。

If he thought that he could buy me off, he would be wrong.

如果他认为他可以收买我，那他就大错特错了。