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One of the problems we have seen I that when we give a drug that reduces appetitive like the Melanocortin 4 receptor agonist, that that tends to raise the blood pressure and of course that is undesirable in treating hypertensive patients to have a further rise in blood pressure so we would like to understand the molecular signaling pathways in the brain that allow for appetite, metabolic function, and blood pressure to be differentially controlled and therefore attack those different targets in treating not only obesity but also hypertension.

我们所遇到的一个难题是，当我们使用一种药物减低食欲，如黑皮质素受体4，有可能会增加血压。当然，血压进一步升高对于治疗中高血压患者是不受欢迎的。所以在高血压和肥胖的治疗中，我宁愿了解脑影响食欲、代谢功能和血压的分子信号途径，由此寻找差异性控制、进而治疗不同的目标。

During the distillation of apple brandy by traditional techniques, higher temperature would inevitably induce chemical damage or disruption of heat-sensitive flavoring compositions and further deteriorate the quality of apple brandy.

传统蒸馏方法的高温处理会不可避免地造成香味物质的损失和热敏性物质的破坏，影响白兰地的品质。

In software design, the embedded operating system was taken as software developing platform, which can supply a better alternating interface between human and computer and stronger application program interface, and as a result real-time response and running efficiency of software were enhanced further.

在软件设计上，采用了嵌入式操作系统作为软件开发平台，从而为用户提供良好的人机交互方式和较强的应用程序接口，进一步提高系统的实时性和软件的运行效率。

This letter is to further my application to your graduate program.

这封信是为了进一步申请而写的。

In this paper,a model frame of the simulation system is given,a further explanation is made for simulation model of terminal guidance radar from the point of view of simulation reliability and the application of ECM technology in terminal guidance radar of antiship missile is introduced.

文中给出了该仿真系统的模型框架，从仿真可信度的角度对其中的末制导雷达仿真模型作了进一步的说明，并介绍了该仿真系统在针对反舰导弹末制导雷达的电子干扰技术研究方面的应用。

It utilizes the fuzzy theory to appraise and provides the basis for further research on risk management and control.

运用模糊理论进行评价，为进一步对其风险的管理和控制提供依据。

On the based of the previous study, made a further study on the appraisement and the empirical study of the development of the enterprise.

在借鉴前人研究成果的基础上，将对企业持续成长的评价研究和实证分析更推进了一步。

Once a stable time step is found, further reduction will not appreciably increase solution accuracy.

一旦找到一个稳定的时间步长，进一步减少它不会显著增加解的精度。

I'm apprehensive of further defeat in the competition.

我担心在比赛中再次失利。

Further phenotypic analysis showed that the Al-412 was significantly reduced in conidiation with only 7% conidia of the wild type strain, was unable to form appressorium on hydrophobic surfaces and was

上述结果表明，Al-412突变体表型的改变可能是由于T-DNA插入而使某一具有重要生物学功能的基因失活所致。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。