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H pylori infection increases the expression of TFF2 in deeper parts of the fundic gland, and is also associated with the degree of glandular atrophy.

在轻、中度和重度萎缩之间有显著性差异(P.01)。

Key Words: Trefoil factor family 2; Helicobacter pylori ; Fundic gland; Mucous neck cell; Pseudopylori gland metaplasia

H pylori 感染增加在腺底部的TFF2表达,并与黏膜的萎缩程度有关。

Technical success was obtained at the level of 87. 5% for 31 operations in 28 cases. Hemostasis on the spot was successful in 9 cases of acute patients, with only 1 case failed. Follow-up visit demonstrated that re-bleeding rate was 14. 3% within 1~15 months, and endoscopic examinations showed the fundic varices disappearance or marked improvement of 87. 5%. The mortality rate for acute patients in operation was zero.

28例31次操作技术成功率为87.5%,9例急诊患者栓塞后8例即时止血成功,失败1例,术后1个月~15个月随访期间再出血发生率为14.3%,术前与术后消化道钡餐造影或内窥镜检查对比观察胃底静脉曲张消失或明显改善率85.7%,急诊患者术中死亡率为零。

In fundic strips, ghrelin and GHRP-6 could decrease the on-response induced relaxation and increase off-response induced contraction of the muscle, with the effect of Ghrelin obviously stronger than that of GHRP-6.L-NNA could increase the effects of Ghrelin and GHRP-6-induced muscle contraction, and L-AA could decrease their effects.

在胃底部,Ghrelin和GHRP-6可使开电刺激诱导的平滑肌舒张活动减弱,断电刺激诱导的肌条收缩活动增强,且Ghrelin作用明显强于GHRP-6.L-NNA可显著增强Ghrelin和GHRP-6的促平滑肌收缩效应,但L-AA可显著减弱该作用。

No significant difference indrinking capacity was found between HS and FD and its non-early satiety subgroup.Ⅱ. Pathological findings in FD fundic mucosa and its relationship with WLT.(1) significant difference was found in 5-HT positive cell counting between early satietyand non-early satiety subgroups(P.05). but no difference in mast cell counting, activity,and H.

6HS组与FD组及FD的早饱和非早饱亚组在半排时间、排出量和排出率存在显著差异(P.05),HS组的半排时间、排出量和排出率显著低于FD组及FD早饱和非早饱亚组:HS组与FD的早饱亚组之间的阈值饮水量和饱足饮水量存在显著差异(P.05),HS组饮水量显著高于早饱组:HS组与FD组及HS组与FD的非早饱亚组之间的阈值饮水量和饱足饮水量均不存在显著差异。

Gastric glands distributed in fundic regions at 5-8 DAH. At this stage, supranuclear vacuoles occurred in the anterior intestine and eosinophilic granules occurred in the posterior intestine. The volume of the liver increased. Zymogen granules were seen in the exocrine pancreas and the langerhans was obvious. From 21 DAH to 33 DAH, the digestive system developed to be perfect.

孵出后5-8 d的仔鱼,胃基底部的粘膜上皮下出现胃腺,前肠粘膜层中出现核上空泡,后肠粘膜层中出现嗜曙红颗粒,肝脏体积增大,在胰脏的腺泡中出现大量的嗜酸性酶原颗粒,胰岛明显。

Results By using zinc-iodide-osmium staining, the tubulo-vesicular system of parietal cells of fundic gland was manifested as numerous fibrous structures under HVEM. The nematolysosomes was often demonstrated as branching in shape and anastomosed with each other making a network system in cytoplasm under the visual field of the three dimensional electron microscopy combined with AcPase cytochemistry.

结果高压电镜下显示,锌-碘-锇酸染色方法制备的标本胃底腺壁细胞的微管泡系统呈无数纤维状结构;AcPase结合三维电子显微镜观察显示,线性线粒体在胞质中常呈分支状并互相吻合成网。

Following studies had been performed:(1)repetitive WLT and real-time ultrasonography had been performed to 18 HS and 40 FD toassess the reproducibility and influencing factors.(2) correlations of WLT with symptomscore and electrogastrography had been analysed.(3) differences ofWLT between HS and FD had been compared.(4) methophenolane andimmunohistochemistry stain of gastric fundus mucosa biopsy from 40 FD patients hadbeen performed to analyse the correlations of symptom score and WLT with count andactivity of mast cells, 5-HT level, and H.Pylori infectious status.(5) the effect of oralsumatriptan to proximal stomach function in 10 HS and 10 FD had been assessed, so as toestablish the possible regulating mechanism of fundic relaxation, explore the therapeuticpotential and feasibility of sumatriptan on FD.Results:I. Evaluation of WLT and its application in FD management.

我们主要进行以下几个方面的研究:(1)对18名健康人及40名FD患者重复进行水负荷试验并结合B超声对近端胃的实时监测,评价水负荷试验结果的可靠性并分析其影响因素;(2)观察水负荷试验结果与症状积分及体表胃电结果的相关性;(3)比较FD患者和健康成人水负荷试验结果的差别;(4)对40名FD患者胃底粘膜活检组织进行免疫组化染色和甲苯胺蓝染色,观察FD患者的症状及水负荷试验结果与胃底粘膜肥大细胞、5-HT表达情况及H.pylori感染情况的相关性:(5)观察口服舒马曲坦对10名健康人及10名FD患者近端胃功能的影响,并由此推测胃底舒张运动调节的生理机制,探讨口服舒马曲坦治疗FD的可行性。

Methods: For 56 cases of arterial bleeding, performed angiography in the artery which was suspected to be the bleeding one, and then infused the embolus into the bleeding after super-selection to embolize it. For 17 cases of esophageal veins and fundic veins bleeding caused by the higher blood pressure in portal vein, we performed angiography in portal vein stem through puncturing the liver, found the bleeding spot, then infuse the embolus into the bleeding veins through super-selection to stop bleeding.

56例动脉性出血采用Seldinger氏法,经股动脉穿刺将导管选择插入可疑出血的动脉内先行DSA检查,明确诊断,再超选择插入出血动脉内注入栓塞材料,栓塞出血动脉。17例门静脉高压致食管胃底静脉曲张破裂出血,则采用经皮穿肝至门静脉主干行门静脉造影,明确出血部位,再超选择插管至出血静脉注入栓塞材料进行栓塞治疗。

The off-contractions were also cholinergically mediated as they disappeared under non-adrenergic,non-cholinergic conditions using atropine and guanethidine.In fundic strips,ghrelin and GHRP-6 induced on-relaxation and off-contraction and both ghrelin and GHRP-6 may significantly reduced on-response and increased off-response.

在胃底部,Ghrelin和GHRP-6可使on-response诱导的平滑肌舒张活动减弱,off-response诱导的肌条收缩活动增强,且Ghrelin作用明显强于GHRP-6.L-NNA可显著增强Ghrelin和GHRP-6的促平滑肌收缩效应,但L-AA可显著减弱该作用。

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这两个团体间的分歧难以掩饰。

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