查询词典 full-blown

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Since full-blown neurotherapy treatments have been prohibitively expensive for a large segment of people interested in this holistic alternative health care approach, the biofeedback system offered by Wild Divine has brought this technology into the realm of being affordable for just about everyone.

由于全套neurotherapy疗法已用于昂贵的很大一部分人关心这个整体替代的保健方法，生物反馈系统所提供的野生神了这一技术领域正在负担得起的只是每个人。

Sybil's arrival was inauspicious, it noted: weeks after she arrived, Darling was grappling with the first run on a bank in over a century at the Northern Rock, presaging last year's full-blown global financial crisis.

该报还写道，西比尔的到来预示着不幸，她到后仅几周，达林就为了对付百年一遇的北岩银行问题而焦头烂额，而这又成为去年席卷全球的金融危机的先兆。

For this reason, attempts have been made to identify individuals who are at increased risk of AD and to test interventions that might delay the progression of prodromal symptoms to full-blown dementia, the authors write.

基于这个理由，企图已作出确定个人谁是风险增加的广告，并以测试的干预，可能延误的进展前驱症状全面吹老年痴呆症，作者写。

The team next scanned 18 patients with prodromal symptoms and then followed up with them every 3 months for 2 years to evaluate whether their symptoms had worsened. Seven patients eventually developed full-blown psychotic disorders.

这个小组接下来扫描18位有前驱症状的病人并在2年时间里每3个月跟踪病情以评估他们的症状是否有恶化。7位病人最后发展成深度精神错乱。

The team next scanned 18 patients with prodromal symptoms and then followed up with them every 3 months for 2 years to evaluate whether their symptoms had worsened. Seven patients eventually developed full-blown psychotic disorders.

这个小组接下来扫描18位有前驱症状的病人并在2年时间里每3个月跟踪病情以收集他们的症状是否有恶化。7位病人最后发展成深度精神错乱。

These are followed by an increasing lack of coordination, culminating in full-blown proprioceptive failure.

紧接着是不断失去协调性，最后导致完全的本体感知缺失。

A couple in full prom regalia walking toward the building are suddenly lifted into the air and blown away by the storm.

一对舞会装扮的男女，走向建筑物，忽然间被大风吹到空中。

The coves are done in white, and various racing graphics complete the full blown racer look!

小海湾在白中被做，而且各种不同的空转图形完成完整的吹出叁赛者神情！

A few more of these disconnects and you will have a full blown situation on your hands.

数以上断开，您将有充分的吹的情况在您的手中。

According to my definition, the Manchurian Candidate is an experimentally created dissociative identity disorder that meets the following four criteria

根据我的定义，满州候选人是一个创造分离身份混乱的实验，它符合下述的4条标准

I'd be chuffed to play at a World Cup, but I have many years ahead of me in the game so I hope to have more opportunities.

我会chuffed发挥在世界杯，但我有很多年的比赛在我前面，所以我希望有更多的机会。