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This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

Hence, the modulus of rigidity, G, of glulam was measured by vibration test method in order to realize the shear deflection effect. The E/G values of Japanese cedar, Taiwania, Douglas-fir, and southern pine glulam were ranged form 13.2 to 14.5, 14.6 to 16.6, 12.1 to 16.6 and 16.0 to 19.1, respectively. The pure MOE was also obtained. The Ep and MOR values of glulam were ranged from 10.6 to 13.4 GPa and 48.3 to 61.9 MPa for Japanese cedar, ranged from 12.1 to 15.0 GPa and 41.8 to 58.8 MPa for Taiwania, ranged from 10.5 to 16.4 GPa and 37.2 to 65.6 MPa for Douglas-fir, ranged from 14.5 to 20.6 GPa and 70.2 to 78.48 MPa for Southern pine, respectively.

而消除剪力挠曲影响，即可得集成材之抗弯弹性模数真实值与抗弯强度，依本研究配置所得之柳杉集成材之Ep值与MOR值分别为10.6-13.4 GPa与48.3-61.9 MPa；台湾杉集成材之Ep值与MOR值分别为12.1-15.0 GPa与41.8-58.8 MPa；花旗松集成材之Ep值与MOR值分别为10.5-16.4 GPa与37.2-65.6 MPa；南方松集成材之Ep值与MOR值分别为14.5-20.6 GPa与70.2-78.4 MPa。

The present invention adopts the technical proposal of adopting ZSM-5 mesoporous molecular sieve raw powder with a silicon-aluminum mol ratio SiO2Al2O3 of 20 to 1000 and a weight percentage of 20 to 100 percent as well as at least one caking agent selected from SiO2, clay and Al2O3 to extrude, tablet or spray into shape; then treating for 1 to 8 hours by 0.1 to 3 mol/l of at least one ammonium liquor from ammonium nitrate, ammonium chloride or ammonium sulphate or 0.1 to 8.5 mol/l of at least one acid liquor from muriatic acid, nitric acid, vitriol or acetic acid under a temperature of 20 to 90 DEG C; then using steam to treat for 2 to 15 hours under the temperature condition of 400 to 700 DEG C; using a liquor of 0.1 to 3mol/l selected from at least one of oxalic acid, citric acid or maleic acid under a temperature condition of 20 to 90 DEG C to dip for 2 to 5 hours to obtain the modified molecular sieve catalyst, thus better solving the problems.

本发明通过采用硅铝比SiO2/Al2O3为20～1000重量百分比计20～100％的ZSM-5介孔分子筛原粉与余量的选自SiO2、粘土或Al2O3中至少一种粘结剂挤条、压片或喷球成型；再经过0.1～3摩尔/升选自硝酸铵、氯化铵或硫酸铵中的至少一种铵溶液或0.1～8.5摩尔/升选自盐酸、硝酸、硫酸或乙酸中的至少一种酸溶液在温度20～90℃下处理1～8小时；然后在温度为400～700℃条件下水蒸汽处理2～15小时；再用0.1～3摩尔/升选自草酸、柠檬酸或马来酸中至少一种在温度为20～90℃条件下浸渍2～5小时得所需改性分子筛催化剂的技术方案较好地解决了该问题，可用于甲醇转化制丙烯的工业生产中。

When the human soul turns from itself, and turns to God, dies to itself and lives to God in the Spirit and tempers of the holy Jesus, then only it is delivered from covetousness and sensuality, from a worldly spirit, from all self-interest and self-exaltation, from all hatred and envy.

老我」是与上帝为敌，被它所接触碰到的都会遭败坏破损；因为老我是滋养罪恶的温床，若将内在的老我治死，外在的仇敌也将被制服。

When the human soul turns from itself, and turns to God, dies to itself and lives to God in the spirit and tempers of the holy Jesus, then only is it delivered from covetousness and sensuality, from a worldly spirit, from all self-interest and self-exaltation, from all hatred and envy.

一个人从自己转向神，舍己，但活在神里面，有圣子耶稣的性格，除去一切贪婪、淫乱、爱世界、自义、自高、忌恨和嫉妒。

From Rusticus I received the impression that my character required improvement and discipline; and from him I learned not to be led astray to sophistic emulation, nor to writing on speculative matters, nor to delivering little hortatory orations, nor to showing myself off as a man who practises much discipline, or does benevolent acts in order to make a display; and to abstain from rhetoric, and poetry, and fine writing; and not to walk about in the house in my outdoor dress, nor to do other things of the kind; and to write my letters with simplicity, like the letter which Rusticus wrote from Sinuessa to my mother; and with respect to those who have offended me by words, or done me wrong, to be easily disposed to be pacified and reconciled, as soon as they have shown a readiness to be reconciled; and to read carefully, and not to be satisfied with a superficial understanding of a book; nor hastily to give my assent to those who talk overmuch; and I am indebted to him for being acquainted with the discourses of Epictetus , which he communicated to me out of his own collection.

我从拉斯蒂克斯那里领悟了许多，这使我的性格得以完善和规范；他让我懂得如何不致陷入诡辩论战的歧途，如何不写那些投机取巧的文章，如何不发表急功近利的演说，如何像深藏不露者那样既不显山露水，又能循循善诱、从善如流；他教我力戒文过饰非、靡丽铺张和词藻华美；他教我别装模作样、咆哮于庭，亦不作诸如此类的其它做派；他教我用词简洁，就像拉斯蒂克斯从辛努厄萨写给母亲的书信那样行文；他教我宽以待人，无论他人恶语相加还是错上加错，只要他们有和解之意，必当冰释前嫌、和好如初；他教我用功读书，不满足于一知半解；他教我不要随便附和夸夸其谈的人；我感激他让我熟读爱比克泰德的演讲论文，使我在他的文集之外与他沟通交流。

There are various precious animals in the zoo, such as spotted deer from the Northeast, ostriches and turkeys from Africa, monkeys from Emei in Sichuan, peacocks from Yunnan, and camels from Ningxia; the Children ' s Park may help us to get back the not yet vanished naive and childhood happiness, and arouse our unsophisticated feelings to love life, cherish life and be attentive to the nature.

动物园里有来自东北的梅花鹿，非洲的鸵鸟、火鸡，四川峨眉的猴子，云南的孔雀，宁夏的骆驼等多种珍惜动物；在儿童乐园里，也许还能找回我们尚未泯灭的天真和童趣，唤起我们热爱生活、珍爱生命、关爱大自然的纯真情感。

It came from the children from Macedonia ,a country deeply divided by bitter and bloody conflict,children from the Jewish War Veteran Association of St Petersburg,from Turkey, and children from Poland who had visited Lublin Jewish cemetery and were searching to make sense .we would also like to have the artwork of children from Nanjing, a city that survived the Nanjing Massacre during the Japanese invasion of China ,one of the most abhorring war disasters in recent human history.

许多儿童画作品也来自我们的展出地南京——这个在日本侵华战争中经历了大屠杀的城市。

Whatever they borrowed, this pessimism they did not borrow -- not from Greek thought, which was a joyous acknowledgment of and homage to the beautiful and noble in this world, with a studied disregard of the element of sorrow; not from Egyptian thought, which did not allow its elaborate speculations on retribution and judgment in the netherworld to cast a gloom on this present existence, but considered the universe created or evolved under the presiding wisdom of Thoth; not from Iranian thought, which held to the absolute supremacy of Ahura Mazda and only allowed Ahriman a subordinate share in the creation, or rather counter-creation, of the world; not from Indian Brahminic thought, which was Pantheism pure and simple, or God dwelling in, nay identified with, the universe, rather than the Universe existing as the contradictory of God; not, lastly, from Semitic thought, for Semitic religions were strangely reticent as to the fate of the soul after death, and saw all practical wisdom in the worship of Baal, or Marduk, or Assur, or Hadad, that they might live long on this earth.

无论他们借来的，这悲观，他们并没有借用-而不是从希腊思想，这是一个欢乐的承认和致敬，向美丽的和高尚的在这个世界上，一个研究无视元素的悲哀；并非来自埃及的思想，不容许其拟订的揣测对报应和判断，在地狱投忧愁就这本存在，但认为宇宙的创造或演变下，主持会议的智慧，透特；不是来自伊朗的思想，举行以绝对优势的阿胡拉马自达和只允许ahriman下属分享在创造，或者更确切地说，反创造，整个世界的；不是从印度brahminic思想，这是泛神论单纯和简单，或上帝在住家，在NaY查明，宇宙，而不是宇宙现有的作为矛盾的上帝；没有，最后，从反犹思想，为犹太人的宗教是奇怪的沉默，以命运的灵魂，死亡后，看到所有实际可行的智慧，崇拜巴力，或马尔杜克，或杆，或哈达，他们可能活，只要这个地球上。

Whatever they borrowed, this pessimism they did not borrow -- not from Greek thought, which was a joyous acknowledgment of and homage to the beautiful and noble in this world, with a studied disregard of the element of sorrow; not from Egyptian thought, which did not allow its elaborate speculations on retribution and judgment in the netherworld to cast a gloom on this present existence, but considered the universe created or evolved under the presiding wisdom of Thoth; not from Iranian thought, which held to the absolute supremacy of Ahura Mazda and only allowed Ahriman a subordinate share in the creation, or rather counter-creation, of the world; not from Indian Brahminic thought, which was Pantheism pure and simple, or God dwelling in, nay identified with, the universe, rather than the Universe existing as the contradictory of God; not, lastly, from Semitic thought, for Semitic religions were strangely reticent as to the fate of the soul after death, and saw all practical wisdom in the worship of Baal, or Marduk, or Assur, or Hadad, that they might live long on this earth.

不管他们借来的，这悲观他们不借钱-而不是从希腊认为，这是一个愉快的承认，并表示敬意的美丽和崇高在这个世界上，一个研究无视元素的悲哀；不是来自埃及认为，这不允许其拟定的报复猜测和判断中的地狱，以投下了阴影对本存在，但认为宇宙的创造或进化的主持下智慧的托提；不是来自伊朗的思想，举行了向绝对优势的胡马自达并只允许Ahriman下属份额的创造，而不是对抗或创造，对世界，而不是从印度Brahminic认为，这是泛神论纯粹和简单，或住在上帝，不查明，宇宙，而不是宇宙现有的矛盾上帝；没有，最后，来自犹太人的思想，为犹太人的宗教有奇怪的沉默，以命运的死亡后的灵魂，看到一切实际智慧的崇拜巴力，或马尔杜克，或亚述，或哈达，他们可能长期生活在地球上。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。