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In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果,本研究提示:夏季和低龄是托吡酯引起泌汗障碍的主要危险因素,而托吡酯剂量对泌汗(来源:A44B8787C论文网www.abclunwen.com)功能的影响较小;托吡酯可以抑制小鼠汗液的分泌,小鼠的年龄并不影响这种抑制作用,但托吡酯对小鼠体温无明显影响;托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗;托吡酯不影响汗腺形态及Na,K-ATP酶活性;汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关,而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Disturbances of the sense of smell are frequent.It is estimated to be 19.1%(hyposmia 13.3%,anosmia 5.8%) in adults aged 20 years and older,and 24.5%in adults aged 53 years and older.

在生活中,嗅觉障碍并不少见,有数据显示20岁以上的中青年中19.1%存在嗅觉障碍,其中嗅觉功能减退者占13.3%,嗅觉完全丧失者占5.8%,而在53岁以上的中老年人当中存在嗅觉障碍的人数比例已高达24.5%。

This paper proves that XFPD has better performance than WL in the work of mining XML frequent patterns theoretically and experimentally, and gives a proof of the validity and feasibility of the XML data storage method presented in this paper by the implementation of an antetype model.

本文从理论和实验两方面证明了在挖掘XML频繁模式时,XFPD算法比WL算法具有更加良好的性能,并通过一个原型系统的实现,验证了本文提出的XML数据存储方法的有效性和可行性。

During her childhood, Deborah suffered frequent abuse from her anti-Semitic peers and neighbors.

在她的童年,德博拉频繁遭受虐待从她的反犹太主义的同事和邻居。

Results: The rate of the use of antibiotic was 98%, the ratio of intravenous injection was high, and drug combination and frequent change of drug existed, and the rate of the use of hormone and antifebrile was 82.9%.

结果 抗生素使用率达98%,静脉用药比例过高,存在多药联用和更换过勤现象;激素及退热药使用率82.9%。

Results: The ratio of male patients to female in the group was about 1.8∶1. Frequent clinical symptoms and signs: back and flank pain(69.57%),hydronephrosis(75.65%),deficiency of renal function(52.17%),dilatation of superior segment ureter(39.13%),edema of lower extremities(25.22%), hypertension(22.62%),and oliguria or anuresis(20.87%).

结果: (1)该病患者男∶女为1.8∶1,腰背部疼痛80例(69.57%),肾积水87例(75.65%),肾功能损害60例(52.17%),上段输尿管扩张49例(42.61%),下肢水肿29例(25.22%),高血压26例(22.61%),少尿、无尿24例(20.87%)。

Dr. Lawrence Appel of the Johns Hopkins University, who headed the panel, explained,"While drinking water is a frequent choice for hydration, people also get water from juice, milk, coffee, tea, soda, fruits, vegetables and other foods and beverages, as well."

约翰霍普金斯大学的Dr。 Lawrence Appel,作为专家小组的组长,解释道:"当我们喝水作为水合的一般选择时,人们也从果汁、牛奶、咖啡、茶、苏打水、水果、蔬菜以及其他食物和饮料中获取水分。"

The experimental results show that the approximate frequent itemsets method isfeasible and the compression quality is good.

实验结果显示这种近似的频繁项集压缩方法是可行的并且压缩质量好。

The uppermost system for enterprises running automobile appurtenances is warehouse management, because scientific warehouse management will improve benefit for the whole enterprise. Besides, it can solve the problems caused by the frequent flow .

汽车配件经营企业最主要的就是仓库管理,科学的仓库管理将提高整个汽车配件经营企业的经济效益,并且可以解决仓库材料的频进频出带来的烦恼。

On the earthquake archipelago of Japan, it is no surprise that tremors are frequent in the vicinity of volcanoes.

在有"地震列岛"之称的日本,火山周围频繁的微震一点都不奇怪。

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As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸,那乌黑、忧郁的眼睛,她便会相信,他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失

But because of its youthful corporate culture—most people are hustled out of the door in their mid-40s—it had no one to send.

但是因为该公司年轻的企业文化——大多数员工在40来岁的时候都被请出公司——一时间没有好的人选。