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In it, John Hohneker, MD, vice president, US clinical development and medical affairs in the oncology division at Novartis, notes that supplemental data available on the Nature Medicine Web site indicates that all of the patients who suffered cardiotoxic side effects from the drug had NYHA class 1 functioning and normal left ventricular ejection fractions.

信中提到，我们藉此提供您有关Gleevec和自然医学线上版的一篇近来受到媒体关注的文章的讯息；信中，Novartis肿瘤部门之美国临床发展与医疗事务副总裁John Hohneker医师指出，因此药所致之心脏毒性副作用是属于NYHA class 1且仍有正常左心室射出分率，相关资料可在自然医学网站上获得；些病患数本来就有类似状况，如高血压、糖尿病和冠状动脉疾病。

In the course of establishing standard operating procedure, The temperature, time , the feasibility without decorticating and efficiency were investigated when alliinase was deactivated used a dry heating apparatus in tunnel type, but the efficiency can be achieved less than 70%, need to be improved; The reformative cribriform plate has been proved to be good in practice result in pulping enzyme-deactivated garlic without dehulling; The extraction efficiency achieved more than 90% when volumic ratio of 20% alcohol and water is 3 I 1 and 2:1 was adopted to extract alliin two times respectively; During exact filtration, the ratio of diatomite in precoating and filtration was 3% and 1% respectively, the losses of alliin adsorbed by diatomite in extraction solution were not remarkable. In the stage of alliin isolation by ion exchange resin, three simple and sensitive detected measures were successfully adopted to control the whole process; the efficiency of alliin isolation was similar to laboratory results; The alliin yield was over 50% in acidic fractions and the purity quotient of alliin achieved above 50% after drying; Furthermore, the phenomenon was found that losses of alliin were seriously affected by the temperature and time periods in concentration.

在制定中试生产标准操作规程中，考察了隧道式干热烘干机杀酶的温度、时间和效率，干热灭酶效率只能达到70%，待改进；改良的筛板使带皮打浆效果良好，证明非脱皮熟蒜打浆的可行性，减少了工序，降低了成本；提取过程中，20%酒精分别1∶3和1∶2提取2次，效率达90%以上；硅藻土板框过滤时，探索了精滤过程中提取液中预涂和过滤时硅藻土的比例分别为3%和1%，并考察硅藻土对蒜氨酸的吸附损失，滤液澄明度良好，蒜氨酸损失很少；在树脂吸附分离阶段，采用三种简便灵敏检测手段控制生产过程，分离蒜氨酸的效果与实验室一致，酸性流分中蒜氨酸收率可达50%以上，干燥后蒜氨酸纯度达50%以上；试验发现浓缩蒜氨酸洗脱液时温度和浓缩时间对蒜氨酸损失的具有很大影响。

Under 100% of natural light, Pinus massoniana had highest values of maximum photosynthetic rate, light saturation point, light compensation point, dark respiration rate, the apparent quantum yield, leaf total electron flow rate and photochemical fluorescence quenching, whereas Cryptocarya concinna exhibited maximum fractions of total electron flow partitioned to photorespiration.

结果表明，在100％光下，马尾松有最高的最大光合速率、光饱和点、光补偿点、暗呼吸、表观量子效率和总电子传递速率，光化学猝灭也最大。

The antibacterial activities of most of fractions were similar to the pomegranate peel extract.(7) Respiratory inhibition experiment showed that the respiration of thallus was inhibited mainly through the hexose monophosphate pathway, which leaded to be short of NADPH, and induced metabolic function dysfunction. Growth curve assay showed that the pomegranate peel extract inhibited cytodieresis in logarithmic growth phase. After exposure to the pomegranate peel extract, bacterial protein was analyzed by SDS-PAGE. The results showed that protein synthesis was inhibited, especially for large molecular weight protein.

7呼吸抑制试验结果表明，石榴果皮提取物主要是通过抑制HMP途径，导致还原力NADPH缺乏，引起代谢功能障碍，达到抑菌的目的；加药组和正常组金黄色葡萄球菌生长曲线的对比结果表明，石榴果皮提取物能够抑制金黄色葡萄球菌对数生长期的菌体分裂；SDS-聚丙烯酰胺凝胶电泳分析表明，石榴果皮提取物能够抑制菌细胞蛋白合成，尤其对菌体内大分子量蛋白作用最明显。

By bioactivity-guided isolation, 14 compounds were obtained from the active fractions. 13 of them were determined as 9,9'-dihydroxy-8,8'-dimethoxy- l,r-methyl-lH,lH'-[4,4']binaphtha

本研究利用稻瘟霉筛选体系对红葱的60％乙醇提取物及其氯仿、正丁醇和水的萃取部分进行了活性筛选，并对活性部位的活性化学成分进行了跟踪分离，从中分离得到十四个化合物，利用物理化学和光谱学的方法对其中十三个化合物的结构进行了鉴定，分别为9，9'-二羟基-8，8'-二甲氧基-1，1'-二甲基-1H，1H'-[4，4']双萘并

Vegetation fractions in different districts of Wuhan were calculated based on remote sensing images (TM images and ETM+ images) in 1988,1991,1996 and 2002 by employing method for dimidiate pixel model,and the vegetation fraction maps of different periods were generated to analysis the temporal change of vegetation fraction of Wuhan area.

利用1988、1991、1996和2002年4个时相的TM和ETM+遥感影像为数据源，以归一化植被指数像元二分法为植被覆盖度估算模型，计算了武汉地区不同时期的植被覆盖度，生成了该地区不同时序的植被覆盖度图，以此分析武汉地区植被覆盖度的时空变化。

Binary systems The temperature T, the liquid-phase xi and vapour-phase yi mole fractions at 101.3 kPa for the systems dipropyl ether (1)+ 2-ethoxyethanol (3) and 1-propyl alcohol (2)+ 2-ethoxyethanol (3) are reported in Tables 4 and 5 and plotted in Figs.

3.2。二元体系两种二元体系在常压下的温度T、液相xi和蒸汽相yi 的莫尔比率见表4和表5，以及图2和图3。

The mole fractions of unsubstituted, monosubstituted, disubstituted, and trisubstituted anhydroglucose units are in very good agreement with Spurlin model during the determined range.

在测量的范围内，未取代、一取代、二取代和三取代无水葡萄糖单元的摩尔分数分布和Spurlin模型非常吻合。

Relationships between durene modified pitch properties, such as soften point,coke yield and viscosity, and pitch fractions, especially TS fraction and PI fraction had been investigated.

考察了不同压力体系中均四甲苯改性沥青的TS组分和PI组分与沥青软化点、焦化值及粘度三种性能参数之间的相互关系。

Following the protocol, you collect, the first protein fraction that exits the column, and discard the rest of the fractions that elute from the column later.

根据方法，你收集柱子上出来的第一个蛋白质组分，弃去后来流出的其它蛋白质组分。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。