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White nails, found in the accident and loss of blood and shock; chronic diseases are found in anemia, hookworm disease, chronic gastrointestinal bleeding, tuberculosis hemoptysis, pulmonary heart disease and so on; as if a nail white glass, while the characteristics of liver cirrhosis; nail change White, thin, soft, was particularly prevalent in the chronic wasting disease; yellow nail is the lack of vitamin E hypothyroidism, nephrotic syndrome, and other symbolic; gray nails are often suffering from Onychomycosis, a performance for the initial stage next to the itching, Following the nail is deformed, but was dull gray; purple nails with a small red thorn is caused by hypoxia, indicating pulmonary heart disease; nail half red, half white (commonly known as a yin and yang) is not a manifestation of renal function; white nail Flocculation, or white, zinc deficiency may be, anemia or gastrointestinal system is sick; nail spots is the emergence of the performance of the poisoning; redness around the nail, mostly lupus erythematosus and in patients with dermatomyositis; nail root A blue and a half months is a reflection of peripheral circulation; obvious red nails, is the performance of heart failure; a clear and a half months, prompted the digestive system function better absorption; On the other hand, there is no clearance on a narrow or a half months, that is, Tip of the digestive system problems.

指甲变白时，急症见于失血、休克；慢性病则见于贫血、钩虫病、消化道慢性出血、肺结核咯血、肺源性心脏病等；如果指甲白得像毛玻璃一样，则为肝硬化的特征；指甲变白、变薄、变软，多见于慢性消耗疾病；指甲变黄是缺乏维生素E甲状腺功能减退、肾病综合症等象征；指甲变灰往往是患了甲癣，表现为初期甲旁发痒，继则指甲变形，失去光泽而呈灰白色；指甲青紫伴有红色小刺是缺氧引起的，预示肺心病；指甲一半红色、一半白色是肾功能不好的体现；指甲出现白点或絮状白斑，可能是缺锌、贫血或胃肠道系统有病；指甲出现黑斑是中毒的表现；指甲周围出现红斑，多见红斑性狼疮和皮肌炎患者；指甲根部的甲半月呈蓝色是末梢循环不良的反映；指甲明显发红，是心力衰竭的表现；甲半月明显者，提示消化系统吸收功能较好；反之，没有甲关月或甲半月窄小，即提示消化系统有毛病。

The rate of repetitive sequences was 2.55% and no SINEs, LINEs, LTR anti-transcription elements or DNA transposon elements were found, although one11 microsatellite was found. 2 In the P1 promotor region, sequence homology between the Tibetan sheep and mouflon, goat, cattle and European bison was 99.7%, 94.2%, 85.9% and 86.5%, respectively, while that for exon 1A was 99.0%, 97.0%, 92.7% and 94.6%, respectively. 3 The molecular phylogenetic tree among these species, constructed by the neighborhood joining method based on the sequences of no-coding region of the GHR genes, placed the two Bovinae species on one branch and the three Caprinae species on the other.

在该非编码序列中，重复序列所占比率为2.55%，不存在SINEs、LINEs、LTR类反转录元件和DNA转座子元件，而发现存在一11微卫星位点；(2)在启动子P1区，藏绵羊与摩弗伦羊、山羊、普通牛、欧洲野牛各物种间同源性大小分别为99.7%、94.2%、85.9%、86.5%；而在外显子1A区段，藏绵羊与摩弗伦羊、山羊、普通牛、欧洲野牛各物种间同源性大小分别为 99.0%、97.0%、92.7%、94.6%。

Similarly, if the strong shear, which could suppress all the scattering in the quiescent two phase region, stopped, the follow-up phase separation also displayed characteristics of anisotropism and relaxation, In this dissertation, the transposed"butterfly'and"streakpattern were observed for the first time within the shear-history-influenced phase separation, which is found closely relevant to the anisotropical relaxation behavior of macromolecules. 5. The phase separation kinetics of PS/PVME under oscillatory shear was further studied on the base of that done under simple shear. It is found that, under specific temperature and strain amplitude, the occurrence of phase separation is strongly contingent on oscillatory frequency and only intermediate frequency could effectively induce phase separation; If all considered oscillatory shear could stimulate phase separation, a fixed frequency can maintain specific most probable phase size and higher frequency yields smaller phase, which makes a higher elasticity but weaker stress relaxation; Furthermore, higher frequency can produces stronger compulsory oscillation on the MPPS but won't change the mean of the MPPS. Under given frequency and strain amplitude, the phase separation kinetics dramatically depends on the phase angle of oscillation and the phase separation corresponding to different phase angle follows different dynamical process.

在简单剪切场下相分离动力学研究的基础上进一步对振动剪切场下PS／PVME的相分离动力力学进行了尝试性的研究，发现：在一定温度和振幅条件下，相分离的发生强烈的依赖于振动频率，只有中等频率的振动剪切才能有效地促进相分离的发生；在都能使相分离发生的前提下，一定频率的剪切能够使体系维持一定的最可几相尺寸，较高频率的剪切导致体系形成的相区尺寸较小，因而体系的弹性效应较强而应力松弛效应较弱；同时，更高频率的剪切对最可几相尺寸的强迫振动效应越强，但不会使最可几相尺寸的平均值发生改变；在一定的振幅和频率条件下，相分离的动力学过程会强烈地依赖于相位角，不同相位角对应的相分离遵循不同的动力学过程但机理一样。

When the investigators saw him at age four years, they found him on physical examination to be normal except for having two to three cm of dry, erythematous patches on both cheeks, as well as "mildly dry" skin on the flexor/extensor surfaces of both arms. They subjected him to a standard battery of tests and found negative results on skin prick testing to milk, eggs, peanuts, and dust mites, and serum IgE testing was also negative.

在这位男童四岁时，研究人员对他进行诊疗，在理学检查时发现，除了双颊2到3公分的乾躁、红肿斑块，以及双手伸肌或是屈肌的表面轻微乾躁外，大部分都是正常的；研究人员请这位男孩接受标准电池测试，结果发现皮肤刮痕试验结果对牛奶、鸡蛋、花生与尘蹒没有过敏反应，而且血清IgE试验呈阴性反应。

Several anti-tumor cell lines and carbonic anhydrase Ⅱ model were established. More than 10000 compounds and extracts from plants were screened using these models and about 10 compounds showed strong inhibitory activities. Two species of plants Inula helianthus-aquatica and Saussurea deltoidea were chosen to investigate chemical and bioactivity constituents based on the results of screening of extracts and fractions. 58 compounds were isolated and identified from these two plants, 6 compounds were found to be new and 14 compounds showed anti-tumor activities. We also studied the anti-tumor mechanism of the compound bigelovin isolated from Inula helianthus-aquatica. Bigelovin was found with apoptotic activity against cell line U266 by lowering the amount of important transcription factor E2F-1 which inhibits the cell cycle at G0/G1 stage. Docking study on 7 natural new phenolic inhibitors of CA Ⅱ and 3D-QSAR study on 61 sulfonamide inhibitors of CA Ⅱwere also investigated. The calculated results were in good correlation with experimental results.

基于以上两种重要疾病和研究组方向，本论文工作开展了多个肿瘤细胞株和碳酸酐酶Ⅱ靶标模型的建立和筛选工作，累计筛选1万多个/次样品，发现10余个活性较强化合物；从粗提取物筛选结果中选取两种抗肿瘤活性强的菊科植物水朝阳旋覆花(Inula helianthus-aquatica)和三角叶凤毛菊进行了系统化学和活性成分研究，分离鉴定了58个化合物，发现6个新化合物和14个抗肿瘤活性化合物；通过合作对水朝阳旋覆花中活性较强的bigelovin进行了抗肿瘤作用机制研究，发现它可能是通过降低G2期重要的转录因子E2F-1，致使细胞周期阻滞在G0/G1期，引起多发性骨髓瘤U266细胞凋亡；开展了7个新的天然酚类CAⅡ抑制剂的对接研究和61个合成的系列磺酰胺类CAⅡ抑制剂的3D-QSAR分析，结果表明计算与实验一致。

Results: The results showed that:(1) The three types of NOS immunoreactivity were not found in rat testis until 30 days after birth;(2) NOS1 immunoreactivity was found in a few spermatocytes in rat testes on postnatal 30 days, and in spermatozoa present at the lumen surface of seminiferous tubules and some Leydig cells on postnatal 60 days;(3) NOS2 immunoreactivity appeared in a few spermatocytes, Sertoli cells and peritubular myoid cells on postnatal 30 days. On postnatal 60 days, NOS2 immunoreactivity appeared in some Leydig cells, peritubular myoid cells, Sertoli cells, very few spermatocytes and the head of immature spermatozoa in some seminiferous tubules;(4) NOS3 immunoreactivity was detected in a few spermatocytes on postnatal 30 days, as well as in the smooth muscle cells of blood vessels on postnatal 30 days and 60 days.

结果：(1)生后4、7、14 d大鼠睾丸未见3种NOS免疫阳性反应；(2)生后30 d少数精母细胞及生后60 d生精小管腔面精子和间质细胞呈NOS1阳性；(3)生后30 d少数精母细胞、支持细胞和管周类肌细胞呈NOS2阳性，而生后60 d NOS2阳性反应见于睾丸间质细胞、管周类肌细胞、支持细胞、极少数精母细胞和不成熟精子头部；(4)生后30 d睾丸内少数精母细胞和血管壁呈NOS3阳性，生后60 d NOS3阳性反应仅见于血管壁。

Results MRI showed symmetric abnormal signals in basal ganglia in 27 patients, in thalami and dentate nucleus in 21 patients, and in corona radiata-centrum ovale in 9 patients. All the lesions were hyperintensity on T1WI. Local hypointensity in basal ganglia was found in 4 patients, while hyperintensity or slight hyperintensity on both T2WI and T2-FLAIR were found in 26 patients, and slight hyperintensity with hypointensity on both T2WI and T2-FLAIR in 1 patient.

结果 27例颅脑MRI表现为双侧基底节区片状对称性异常信号，21例双侧丘脑、齿状核片状异常信号，9例双侧放射冠－半卵圆中心见片状对称性异常信号；27例T1WI上见高信号区，其中4例基底节区病灶内见小片状低信号；26例T2WI及T2-FLAIR见高或稍高信号，1例见稍高、低混杂信号。

Therelationship between the turbulent kinetic energy and its dissipation rate,whichis widely used to parameterize the dissipation rate in turbulence closure models,is found to hold well for both reversing and rotating flows,but with differentcoefficients.Microstructure profiling measurements at two comparative stations (a deepercentral basin and a local shelf break) in the stratified Yellow Sea are analyzed,with emphasis on tidal and internal-wave induced turbulence near the bottomand in the pyenocline.The water column has a distinct three-layer thermohaline structure,consisting of weakly stratified surface and bottom boundary layers anda narrow sharp pycnocline.Turbulence in the surface layer is controlled by thediurnal cycle of buoyancy flux and wind forcing at the sea surface.while thebottom stress induced by barotropic tidal eurrents dominates turbulence in thebottom boundary layer.The maximum level at which the tidally enhanced mixingcan affect generally depends on the magnitude of the tidal current,and it canbe up to 10-15 m in the Yellow Sea.This suggests that,in the deeper regionsof the shelf seas,turbulent dissipation and mixing are very weak at the levelsbetween the near-bottom tidally enhanced layer and the pycnocline.Therefore,these levels provide a significant bottle neck for the vertical exchanges.In theshallow regions,however,the tidally-induced turbulence can occupy the wholewater colum below the pycnocline.A quarter-diurnal periodicities of the turbulentdissipation rate and eddy diffusivity are found at different heights with evidenttime lag.In the relatively flat central basin,the pycnocline is essentially non-turbulent and internal-wave activity is very weak.Therefore,vertical fluxes acrossthe pycnocline decreased to molecular levels.In contrast,internal waves of variousperiods can be always found near the local shelf break.

对强层化季节黄海两对比性站位(分别位于中央海盆区与局地陆坡区)处层化、内波以及湍流混合特征的研究结果表明：1、强层化季节的陆架海水体一般呈现显著的三层热盐结构，在水体近乎混合均匀的上混合层与潮流底边界层之间为强跃层；2、近表层水体的湍流混合强度主要由海表浮力通量的日变化与海表风强迫控制，而在潮流底边界层内，潮混合是水体热量、物质、动量与能量垂直交换的主要机制；3、潮混合影响的深度由潮流大小决定，在黄海，一般可达10-15 m，因此，在水深较深的区域，在跃层与潮混合所至深度范围的上界之间存在湍流混合非常弱的区域，这显著抑制水体内物质的垂直通量，为物质垂直交换的瓶颈，而在水深较浅的区域，潮混合影响范围可至跃层底部，因此物质在跃层以下整个水体中混合非常均匀，当跃层内间歇性强混合发生时，可以产生显著的跨跃层物质输运；4、近底潮致强湍流耗散缓慢地向上传播，底上不同深度处垂直湍扩散系数也具有显著的位相差异，且二者均随时间呈现四分之一周日周期的变化；5、在地形较为平坦的中央海盆区，内波活动非常微弱，因此跃层内湍流混合非常弱，垂直扩散系数为分子扩散水平，跨跃层物质通量受到显著抑制，而在地形变化较为显著的局地陆坡区，内波活动非常活跃，除内潮的影响外，高频内波与内孤立波的影响也很显著，因此跃层内存在很强的间歇性强混合，内孤立波存在的区域，水体湍流混合显著增强。

Dependant on scope of practice, the main types of medicine are life saving medications, which may be commonly found in first aid kits used by paid or assigned first aiders for members of the public or employees, painkillers, which are often found in personal kits, but may also be found in public provision and lastly symptomatic relief medicines, which are generally only found in personal kits.

在实践范围受养人，药品的主要类型是拯救生命的药物，这可能是普遍使用的急救箱中支付或指派公众或雇员，止痛药，这些活动往往是个人包中成员的第一次教唆，但也可能出现在公营提供和最后缓解症状的药物，一般都只有在个人包找到。

The other Chest I found had some Cloaths in it, but of little Value; but by the Circumstances it must have belong'd to the Gunner's Mate; though there was no Powder in it; but about two Pound of fine glaz'd Powder, in three small Flasks, kept, I suppose, for charging their Fowling-Pieces on occasion: Upon the whole, I got very little by this Voyage, that was of any use to me; for as to the Money, I had no manner of occasion for it:'Twas to me as the Dirt under my Feet; and I would have given it all for three or four pair of English Shoes and Stockings, which were Things I greatly wanted, but had not had on my Feet now for many Years: I had indeed gotten two pair of Shoes now, which I took off of the Feet of the two drown'd Men, who I saw in the Wreck; and I found two pair more in one of the Chests, which were very welcome to me; but they were not like our English Shoes, either for Ease, or Service; being rather what we call Pumps, than Shoes: I found in this Seaman's Chest, about fifty Pieces of Eight in Ryals, but no Gold; I suppose this belong'd to a poorer Man than the other, which seem'd to belong to some Officer.

接着，我就上了大船。我第一眼看到的，是两个淹死的人；他们紧紧地抱在一起，躺在前舱的厨房里。看来，船触礁时，海面上狂风暴雨，海浪接连不断地打在船上，船上的人就像被埋在水里一样，实在受不了最后窒息而死。除了那条狗，船上没有任何其他生还的生物。船上所有的货物，也都让海水给浸坏了，只有舱底下几桶酒因海水已退而露在外面，也不知道是葡萄酒还是白兰地。那些酒桶很大，我没法搬动它们。另外，我还看见几只大箱子，可能是水手的私人财物。我搬了两只到我的小船上，也没有来得及检查一下里面究竟装的是什么东西。要是触礁的是船尾，撞碎的是船首，我此行收获就大了。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐