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Among all, deleted in liver cell (DLC-1) gene was found to play an important role in hepatoma in 1998, and after that hypermethylation on the promoter of the DLC-1 gene was found in many other cancers, suggesting that epigenetic modification is another way to control the carcinogenesis. Another gene, Endothelin type B receptor, was found to cause megacolon syndrome by accident while searching the cause of white spot in mouse, and was also found hypermethylation on its promoter in some cancer cells.

在此中，DLC-1基因自从1998年后被发现在肝癌的演化上扮演重要的角色后，在许多其他的癌症上也发现此基因上位於promoter的CpG islands有过度甲基化的现象，推论DLC-1基因的过度甲基化是一种经由epigenetic modification调节细胞癌化的方式。

Conventional CT showed 44 cases of edematous type, dynamic contrast enhanced CT found 28 cases had different degree of necrosis of the pancreatic tissue, 6 cases were found to have focal hemorrhage, peripancreatic fluid accumulation were found in 32 cases, pseudocyst were found in 3 cases, abscess in 2 cases.

常规平扫显示胰腺水肿44例，动态增强扫描显示28例出现不同程度的胰腺组织坏死，6例检出局灶性出血；胰周液体聚集32例；假性囊肿3例，脓肿2例；伴胆石症15例，胆囊肿大或胆囊壁增厚22例；胆急管扩张12例，胰管扩张5例；胸腔积液11例。

Dependant on scope of practice, the main types of medicine are life saving medications, which may be commonly found in first aid kits used by paid or assigned first aiders for members of the public or employees, painkillers, which are often found in personal kits, but may also be found in public provision and lastly symptomatic relief medicines, which are generally only found in personal kits.

在实践范围受养人，药品的主要类型是拯救生命的药物，这可能是普遍使用的急救箱中支付或指派公众或雇员，止痛药，这些活动往往是个人包中成员的第一次教唆，但也可能出现在公营提供和最后缓解症状的药物，一般都只有在个人包找到。

The results indicated that four SOD bands were identified in five tissues, and the band with the biggest mobility ratio were found weakly in gill, digestive gland and adductor muscle but not in foot and mantle. Two ATPase bands were found in four tissues except digestive gland. One MDH band was found in five tissues, but the MDH gene expressed strongly in foot and adductor muscle. Two ME bands were examined in foot, adductor muscle and mantle, but the band with smaller mobility ratio was found in gill and digestive gland.

结果表明，SOD在紫贻贝的5种组织中均有表达，共有4条酶带，但迁移率最大的酶带在足和外套膜中未出现，而在另外3种组织中呈弱表达；ATPase在除消化腺外的组织中都表现为2条带；MDH在5种组织中都表达出1条酶带，其中足和闭壳肌的MDH染色最深；ME存在1~2条酶带，其中迁移率大的条带在5种组织中都有表达，而迁移率小的条带只存在于外套膜、闭壳肌和足中。

After the exposure, the retinas were examined with light and electron microscope. results: under light microscope, irregular nucleoplasm and unclear border of nucleus in the ganglion cell layer were found in the experimental groups of 2 h, 12 h and 24 h. these changes were also found in the inner nucleus layer. under the electron microscope, swollen mitochondria and vacuolized endoplasmic reticulums were found in all the layers of retina in the groups of 2 h, 12 h and 24 h, most obvious in the group of 24 h. in the group of 72 h, only lightly swollen mitochondria and dilated endoplasmic reticulums were found in the ganglion cell layer of retina.

结果： 光镜：实验组中2，12及24 h组均可见视网膜神经节细胞层内细胞核出现核质不均匀，核边界不清，内核层细胞核也有同样改变；电镜：实验组中2，12及24 h组视网膜各层均出现线粒体肿大，内质网空泡样变，以24 h组最为严重，72 h组仅见视网膜神经节细胞层出现轻度线粒体肿大，内质网扩张。

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

Sapphire from Shandon and Hainan commonly have the reaction border, we found out this reaction border enriched with Fe,Mg,and K by testing its components; We also studied the inclusion in the sapphire, and found many KC1 crystal grain with variety of size, a melt inclusion enriched with K,Si, is also found, this may suggest an assimilationary-magmatic course; Besides that, another minerl inclusions such as enstenite, magnetite, chromite, zircon are also found.

观察到了山东、海南蓝宝石普遍存在的反应边，并测试了反应边的成分，证实其以富Fe，Mg，和K为特征；研究了蓝宝石里面的包体，发现蓝宝石里面存在着大小不等的KCl的结晶颗粒，还发现了富K富Si的熔浆包裹体，说明其形成过程中有同化混染的贡献；此外还发现了斜方辉石，磁铁矿，铬铁矿，锆石的包体矿物。

Results: The numbers of Bombesin positive pulmonary cells, the lamina propria S-l00 protein, neuron-specific enolase positive nerve fibers, IgE positive cells, mast cells and IgE positive mast cells significantly increased in bronchiectasis. The changes of pulmonary endocrine cells, nerve fibers and IgE positive cells were more significantly in hyperplastic BALT areas. The S-100 and NSE were found in lymphoid tissue and BALT. A close contact was found between mast cells and the S-100 positive nerve fibers. An IgE positive outer zone was found on MC surface. Mast cells and IgE positive cells were seen in the bronchial epithelium and alveolar septa.

结果：支气管扩张症中，支气管上皮蛙皮素阳性细胞、固有膜S-100蛋白和神经特异性烯醇化酶阳性神经纤维、IgE阳性细胞、MC和IgE阳性MC均显著增多，且在支气管相关淋巴组织增生的区域上述肺内分泌细胞、神经纤维和IgE阳性细胞增多尤为显著，S-100蛋白和NSE阳性神经纤维分布於弥散淋巴组织和BALT中，MC与S-100蛋白阳性神经纤维紧密接触，MC表面有IgE阳性环状带，MC和IgE阳性细胞出现在支气管上皮间和肺泡壁。

In early stage Ⅱ,9/10 was found the traction of biconvex posterior vitreous detachment at fovea. In late stage Ⅱ, 10/14 was found the operculum, and among the opercula, 8/10 was found some evulsed retinal tissue.

期裂孔的早期中有9/10可观察到黄斑前双凸型玻璃体后脱离对中心凹的牵拉；Ⅱ期的晚期中有10/14可观察到裂孔盖膜，这些盖膜中有8/10可观察到含有部分撕脱下来的视网膜神经组织。

The part that has completed at present is as follows: The first day -- Flex foundation, inclusive content has: The data that Flex of understanding of space of work of Flex Builder Flex Builder of understanding of Flex, Flash, Flash Player, AIR overview compiles package to understand MXML component beforehand binds incident of calm processing user to understand incident object to use ActionScript to add incident dictograph to use HttpService to get data the following day -- package is developed, this part includes following video: The MXML component that shows in DataGrid the use of layout container founds data to be defined oneself realizes Value Object kind found found from definition incident define incident oneself kind define project apply colours to a drawing oneself implement the use that explores Flex Bulider is small doohickey the 3rd day -- work in coordination, include: Data test and verify uses long-range object to transmit data format to change data to accuse from list medium procrastinate put data to use E4X to filter XML deploy Flex and AIR application the 4th day -- add visual component, specific content is as follows: Executive navigation container embeds image embeds font founds the layout that is based on a tie to apply a style to combine Adobe CS3 to make package skin found view status animation for MXML component: Skin of component of implementation of behavior and encode of graph of scale of API of plot of union of specially good effect is patulous package the 5th day -- the exercise of behavior form a complete set of timer of Flash of understanding of advanced development skill and code of give typical examples can come the page of Flex In A Week of Adobe government downloads.

目前已经完成的部分如下：第一天——Flex基础，包括的内容有： Flex、Flash、Flash Player、AIR概述了解Flex Builder Flex Builder工作空间了解Flex预编译组件了解MXML 组件的数据绑定处理用户事件了解事件对象使用ActionScript添加事件侦听器使用HttpService获取数据第二天——组件开发，该部分包括如下视频：在DataGrid中显示数据布局容器的使用创建自定义的MXML组件实现Value Object类创建自定义事件创建自定义事件类自定义项目渲染器探索Flex Bulider的使用小窍门第三天——协同工作，包括：数据验证使用远程对象来传输数据格式化数据从列表控件中拖放数据使用E4X来过滤XML 部署Flex和AIR应用第四天——添加视觉组件，具体内容如下：执行导航容器嵌入图像嵌入字体创建基于约束的布局为MXML组件应用样式结合Adobe CS3制作组件皮肤创建视图状态动画：行为和特效结合绘图API绘制图形编码实现组件皮肤扩展组件第五天——高级开发技巧了解Flash定时器的行为配套练习及示例代码可至Adobe官方的Flex in a Week页面下载。

And he is one of the few scouts who are occasionally sent out to have dealings with other peoples.

而他也是少数的几位偶尔会被派出去和外界人打交道的巡逻人员之一。

The sons of Hebron: Korah, Tappuah, Rekem and Shema.

希伯仑的儿子是可拉，他普亚，利肯，示玛。