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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle，CP)和两个19S调节颗粒(regulatory particle，RP)组成的ATP(adenosine-triphosphate，ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心，它是由4个圆环堆叠形成的桶状复合物，其中两侧外环每个环是由α_1-α_7亚基组成，两个内环每个环是由β_1-β_7亚基组成，4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔，其内壁为催化活性位点所在地；外侧α环中心的孔道是底物到达催化中心空腔的通道，一般被α亚基上的N末端所封闭，阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

ESyPred3D through homology modeling forecast sheep C3d three known structures C3d with the same people also formed by nuclear heart and the outer form of the performance of barrel-shaped molecular structure.

通过ESyPred3D同源建模预测可知绵羊C3d三级结构与人C3d一样也形成由核心和外层构成的桶状分子结构。

Helix and angles turns out alternately in Sheep C3d second structure, which helix accounted for 55.12%, strand to 2.31%and coil for the 42.57% of such a structure conducive to the performance of barrel-shaped structure is formed.

绵羊C3d二级结构中螺旋和转角交替出现，其中α-螺旋占55.12%、β-折叠为2.31%，转角区域为42.57%，这样的结构有利于其桶状结构的形成。

Again, a barrier layer 111 is formed by discharge treatment in ammonia.

另外，势垒层111由氨中放电处理形成。

A method of manufacturing a magnetic tunnel junction device, in which a stack ( 1 ) comprising two electrode layers ( 3, 7 ) and a barrier layer ( 5 ) extending in between is formed.

一种磁性沟道结器件的制造方法，其中形成叠层(1)，包括两个电极层(3，7)，和在其间延伸的阻挡层(5)。

After the water-based clean, the low K dielectric layer is formed on the surface of the barrier layer to achieve the composite layer that has a low K.

在以水为基础者清理之后，低的 K 电介体层在障碍层的表面上被形成达成有低的 K 的含有种种要素的层。

The blend material containing the virgin thermoplastic urethane and the scrap material is formed into a layer of a barrier membrane.

将包含未使用过的热塑性聚氨酯和废料的共混材料成形为屏蔽隔膜的一个层。

Another theory suggests that the Shroud may have been formed using a bas-relief sculpture.

另一个理论暗示了裹尸布是使用浅浮雕技术。

This book formed the bas i s of several other strategies to reduce manufacturing mistakes and cut waste.

这本书中形成了最基本的几种其他策略，用来减少制造业的错误，消除浪费。

Spirit has encountered some spectacular examples of basaltic rocks, formed by volcanic processes, with striking textures.

勇气还遇到了非常壮观的玄武岩石群，很明显是形成于火山爆发的过程

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。