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Using genetic analysis we uncovered redox heterogeneities in isogenic cell populations, and revealed functional interlinks between ER protein folding, modification, and quality control systems.

通过基因分析,研究人员揭示了等基因细胞群中氧化还原的异质性,并显示了ER蛋白折叠、修饰和质量控制系统功能间的联系。

Nineteen spots were changed significantly after FA treatment.Thirteen proteins were identified by peptide mass fingerprinting or peptide sequence analysis,including putative nucleoside diphosphate kinase,elongation factor 1-gamma,triosephosphate isomerase,60S acidic ribosomal protein P0,heat shock protein 75 kDa,similar to heat shock 70kD protein binding protein,annexin I,hypothetical protein FLJ34423,microtubule-actin crosslinking factor 1,lamin B2,ATP synthase alpha chain,mitochondrial precursor,proteasome subunit alpha type 6.These identified proteins involved in energy metabolism,translation and RNA processing,protein folding,redox regulation,cell structure and cell signaling.

双向凝胶电泳结果显示,甲醛刺激后19个蛋白斑点发生变化,肽指纹图谱及肽序列标签鉴定了其中13个蛋白斑点,已鉴定的蛋白包括二磷酸核苷酸激酶、延长因子1-γ,磷酸丙糖异构酶、60S酸性核糖体蛋白P0、75kDa热休克蛋白、70kD热休克蛋白样结合蛋白、钙依靠磷脂结合蛋白I、假想蛋白FLJ34423、微管-肌动蛋白交叉连接因子1、核纤层蛋白B2、ATP合成酶α链、蛋白酶体α亚基6,这些蛋白功能涉及转录调节、蛋白折叠、信号传导、能量代谢、细胞骨架等各个方面。

Thirteen proteins were identified by peptide mass fingerprinting or peptide sequence analysis,including putative nucleoside diphosphate kinase,elongation factor 1-gamma,triosephosphate isomerase,60S acidic ribosomal protein P0,heat shock protein 75 kDa,similar to heat shock 70kD protein binding protein,annexin I,hypothetical protein FLJ34423,microtubule-actin crosslinking factor 1,lamin B2,ATP synthase alpha chain,mitochondrial precursor,proteasome subunit alpha type 6.These identified proteins involved in energy metabolism,translation and RNA processing,protein folding,redox regulation,cell structure and cell signaling.

双向凝胶电泳结果显示,甲醛刺激后19个蛋白斑点发生变化,肽指纹图谱及肽序列标签鉴定了其中13个蛋白斑点,已鉴定的蛋白包括二磷酸核苷酸激酶、延长因子1-γ,磷酸丙糖异构酶、60S酸性核糖体蛋白P0、75kDa热休克蛋白、70kD热休克蛋白样结合蛋白、钙依赖磷脂结合蛋白I、假想蛋白FLJ34423、微管-肌动蛋白交叉连接因子1、核纤层蛋白B2、ATP合成酶α链、蛋白酶体α亚基6,这些蛋白功能涉及转录调节、蛋白折叠、信号传导、能量代谢、细胞骨架等各个方面。

For lithologic and stratigraphic traps, their origination might relate to sea level changes and folding.

岩性圈闭和地层圈闭的形成与海平面变化和褶皱运动有关。

WOOD: I got two louvered folding closet doors that my neighbor was tossing and have one standing as a divider in my kitchen.

木制品:我有两扇邻居丢掉的百叶窗折叠衣柜门。一扇作为我家厨房的分隔板。

Derek Fisher lugged the metal folding chair from in front of his locker, halfway across the room.

费舍尔在他的衣物柜前打开了一把折叠金属椅,放在更衣室的中间。

Moulding technology in a variety of packaging such as die-cutting, folding indentation membraned pasting, fenestration, veneer, composite, cutting, bag, etc so as to meet the rapidly growing packaging market multivariety, high-quality, short-period requirements.

通过多种包装成型工艺如模切压痕、烫金、折叠糊盒、开窗、贴面、复合、分切、制袋等,满足迅速增长的包装市场多品种、高质量、短周期的需求。

This monomeric protein has a substantial kinetic barrier to folding and unfolding, and is of great industrial importance.

这个单体的蛋白质在折叠和展开时都有固定的能阻。

This monomeric protein has a substantial kinetic barrier to folding and unfolding, and is of great industrial importance.

这个单体的蛋白质在折叠和展开时都有固定的能量障碍。

Visit folding carton unknown monosomic fedina, typically by gas chromatography and mass spectrometry, through the identification of unknown monosomic by mass spectrometry.

在考察折叠纸盒未知单体的情况时,通常将气相色谱分析法与质量法一起使用,通过质谱法鉴别未知单体。

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And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时,论述了一体化管理体系构建中的几个主要问题,包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。

If you're huffing and puffing at any point during the run, slow down and make sure you can take deep breathes.

如果你任何时候在跑步过程中气喘如牛,降低速度并且确保你能够深呼吸。