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Expression analyses identified increased expression of numerous TGF-beta-related genes that regulate cell proliferation and survival and plausibly contribute to myxomatous valve disease.

他们注意到，多数效应器分子的表达增加降低了TGF-β的信号作用，包括可诱导TGF-β的H3基因、内皮素-1、组织抑制因子金属蛋白酶1、致骨形态学发生的蛋白和&调节细胞增生和存活可能还有促进粘液瘤性疾病的基因&。

We concluded that the Spidroin2 cDNA of Nephila clavipes can be expressed in prokaryotic expression system, and addition of exogenous alanine plays important role in the promotion of expression of the naive gene of spider silk protein.

本研究证实，蜘蛛牵引丝蛋白Spidroin2 cDNA可在原核细胞内正确表达，外源丙氨酸的加入对于提高天然蜘蛛丝蛋白基因在原核系统的表达作用明显。

Simultaneously 15 samples of normal nephric tissue were used as control.The sections from these samples were subjected to immunohistochemical analysis with antibodies directly against uPA and PAI-1 by LSAB method. In this study we adopt semiquantitative analysis to determined the expression of these molecules , and utilized the relevant data processing and statistical analysis to evaluate the correlation between their expression and the clinicopathological features of RCC.Results: 1. The positive rate of uPA and PAI-1 of uPA in RCC were 72%(36/50)and 56%(28/50), respectively.But in control group there was nearly

正常肾组织标本中几乎无阳性染色。2、uPA表达水平与患者年龄、性别、肿瘤病理分级无关(均P＞0.05)，与T分期、淋巴结转移有明显的相关性(r=0.684，P＜0.05；r=0.789，P＜0.05)，uPA高表达多见于T_(3-4)、有转移的RCC.3、PAI-1的表达水平与患者年龄、性别、肿瘤病理分级和T分期无关(P＞0.05)，与淋巴结转移有明显的相关性(r=0.800，P＜0.05)，PAI-1高表达多见有转移的RCC.4、对uPA和PAI-1行相关性检验，uPA在RCC中的表达与PAI-1的表达呈明显正相关(r=0.168，P＜0.05)。5、uPA和PAI-1的表达与淋巴结转移的关系以Logistic回归法进行分析，结果显示uPA与区域淋巴结转移密切相关，uPA是淋巴转移的危险因子(RR=2.718，95％CI=1.150～7.170，P=0.024)，PAI-1则不是淋巴转移的危险因子(RR=1.599，95％CI=0.624～4.102，P=0.328)。

Results Compared with CRF group, nephrogenic hypertension of hemin group was reduced significantly at the 6th, 8th, 10th week after operation, and followed with the decrease of serum creatinine, BUN,urinary protein and the improvement of nephrogenic anemia at the 10th week after operation. Hemin not only increased the expression of HO-1, reduced the expression of ET-1 in the kidney, but also increased the concentration of carbon monoxide, reduced the level of ET-1 in the plasm.

同时，在术后第10周hemin组比CRF组血肌酐、尿素氮、尿蛋白显著降低(P＜0.05)，贫血明显改善(P＜0.05)；肾组织中HO-1表达明显增加，血浆中内源性CO水平明显升高，肾组织和血浆中ET-1水平明显降低(P＜0.05)。

Cerebral ischemia preconditioning can protect the neuron against the injury of the fatal brain ischemia followed, reduce the quantity of dead parenchyma cell, deflate infarct volume, relieve neuralgic impairment, reduce the expression of IL-6, increase the expression of Ngb, reduce the neuronal degeneration, necrosis and tissue edema.

1。缺血预处理能对随后发生的再次脑缺血所致的神经元损伤起保护作用，减轻神经功能缺损症状，减小梗死体积，使海马区IL-6表达减少，皮质区Ngb表达上调，并减轻神经细胞变性、坏死。

Naloxone can play an role in the protection of brain through diminishing neurocyte apoptosis by promoting the expression of Bcl-2 and restraining the expression of Bax,p53 and Fas.

纳洛酮可能通过促进Bcl-2的表达和抑制Bax、p53、Fas的表达来减少脑复苏后神经细胞的凋亡而发挥其脑保护的作用。

Naloxone can play an role in the protection of brain through diminishing neurocyte apoptosis by promoting the expression of Bcl-2 and restraining the expression of Bax,p53 and Fas.

纳洛酮大概议决促进Bcl-2的表达和克制Bax、p53、Fas的表达来淘汰脑苏醒后神经细胞的凋亡而发挥其脑掩护的作用。

Objective To study the expression of connexins 43, 32 in tumors originated from neuroepithelial tissue, and its relationship with expression and histopathological type and index of malignant of tumors.

目的 探讨连接蛋白43、32在神经上皮组织起源的脑肿瘤中表达及其与肿瘤的病理类型、恶性程度的关系。

In neuroepithelial tumors, Cx43\, Cx32 expression varies greatly. Cx43 expression is related to histopathological type and degree of malignant of tumors.

神经上皮组织起源的脑肿瘤中CX表达可下降或缺失，Cx43表达与肿瘤的病理类型及恶性程度密切相关。

METHODS:Nestin expression was detected in 33 cases of neuroepithelial tumors using the immunocytochemical staining. The Nestin positive and negative cells were isolated by magnetic activated cell sorting. Nestin positive cells were culutered, identified, and induced to differentiate. The expression of Nestin protein was detected in Nestin+ cells by RTPCR.

采用免疫组化法检测神经上皮肿瘤组织中Nestin的表达情况，免疫磁珠法分选肿瘤组织中的Nestin+细胞，悬浮细胞培养法进行Nestin+细胞的增殖、分化与鉴定，RTPCR法检测Nestin蛋白在其中的活性表达情况。

Diabetes is a social disease that affects several million people worldwide.

糖尿病是一个社会性疾病，全世界有数百万人罹患此病。

I'll call you on Friday to see if we can reschedule our luncheon meeting at your convenience.

我星期五会给您打电话在您方便的时候我们重新安排我们的午餐约会。