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The regulation of gene expression is to have relations to the assembly of the DNA binding proteins which bind to DNA to initiate the transcription. Some of these proteins have the ability to promote bending or looping of DNA. The FIS protein regulates gene expression in Escherichia coli by this property of bending DNA. There are many researches to discover the mechanism of FIS protein binds to DNA. However the experiment data only show the supposititious results and figure out the model of FIS-DNA complex structure. This research uses molecular dynamics simulation to compute the detail of the interaction between FIS and DNA. We observed FIS prominently affects the DNA bending by the type of local bending. Analyzing the DNA structure properties, roll and slide, also demonstrates the local bending type and region. The hydrogen bonds between FIS and DNA are analyzed to compare with the experiment data. Finally we compute the binding free energy between FIS and DNA to estimate the result of simulation and compare with the value of λ-repressor-DNA complex.

基因的表现与结合於DNA促使DNA转录作用起始的DNA结合蛋白组装有关,一些这类的蛋白质具有促使DNA扭曲或将DNA形成环状的能力,FIS蛋白质即是藉由扭曲DNA的特性调控大肠杆菌基因的表现,目前已有很多的研究发现FIS与DNA结合的机转,然而这些实验的数据仅能显示推测性的结果,进而利用这些结果推论出FIS与DNA聚合体结构的模型,本研究利用分子动态模拟的方式计算FIS与DNA交互作用的细节,我们观察到FIS主要影响DNA的扭曲方式为DNA区域扭曲的类型,并且分析DNA结构特性roll与slide也指出扭曲方式为区域扭曲与其扭曲的区域,我们也分析FIS与DNA之间的氢键,并且与实验的资料作比较,最后我们计算FIS与DNA之间的结合自由能评估模拟的结果,并且计算出的值和λ-repressor与DNA聚合体结构的实验值作比较。

So, with the principle of lowest general energy-consumption for completing observation task, we figure out a kind of greedy heuristic algorithm, testify its convergence, and give its searching supremum and time complexity.

该策略主要思想是结合投标方卫星以往完成观测任务的历史记录,对卫星进行筛选招标,以减轻网络负载和通信量;投标过程中,引入后移空余时间概念,从时间约束和能源约束两个方面来判断投标方卫星是否有"能力"来完成招标的观测任务,并给出相应时间约束和能源约束的检验算法,分析了算法的时间复杂度;评标过程中,基于集覆盖的概念,将任务分配问题转化为集覆盖问题。

Mike Swale: I'm trying to figure out whether you're a total fucking bitch or not.

迈克:我试图弄清你到底是不是个该死的婊子。

There are various traps and switches so try to figure out the levels.

有各种各样的陷阱和交换机,所以尝试计算出的水平。

Figure out a way to create a symbiotic relationship with someone who has the opposite problem from you.

找到一个途径和某个具有相反问题的人建立起一段象征的关系。

In this connection, how to syncretize the existing theoretical viewpoints and carry them through to a form is the question of this paper wants to figure out.

因此,如何将现有的理论观点相互融合并深入探讨,形成一个相对完整的理论体系是本文研究的重点。

For the purpose to figure out location and function relations of three-dimensional syphon's unfolded curve with any bend angle, any diameter and any section, and to make integration of design and manufacturing for three dimensional big-diameter syphon, methods of engineering mathematics and analytic geometry are provided. Syphon's unfolded curve function in three-dimensional station is analyzed and built; the corresponding MATLAB procedures are compiled at the same time.

为了解决弯管在弯曲角度、直径、节数等变化时的三维弯管展平曲线的坐标位置以及函数关系问题,以实现大直径弯管的三维设计与制造的自动化、一体化,通过利用工程数学及画法解析几何的方法,分析和建立了弯管在三维状态下的展平曲线方程,同时编写了相应的MATLAB程序。

Once they get a product, they will take it apart piece by piece and figure out exactly how it works.

一旦他们拿到产品了,他们就一片一片分解开来,然后弄明白它的工作原理。

People should be aware of their angry feelings and figure out where they're coming from;"it's important to take next steps and try to do something about the situation," Denollet told Reuters Health.

研究人员指出,人们应该意识到自己的愤怒情绪并知道它们从何而来,采取措施尽量解决这种状况是很重要的。

Can figure out he is so kind and talktive man , which made so easy half

从谈话中,我能体略到他的健谈,他的善良和友善,半个小时

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推荐网络例句

In the negative and interrogative forms, of course, this is identical to the non-emphatic forms.

。但是,在否定句或疑问句里,这种带有"do"的方法表达的效果却没有什么强调的意思。

Go down on one's knees;kneel down

屈膝跪下。。。下跪祈祷

Nusa lembongan : Bali's sister island, coral and sand beaches, crystal clear water, surfing.

Nusa Dua :豪华度假村,冲浪和潜水,沙滩,水晶般晶莹剔透的水,网络冲浪。