查询词典 fibrosis

Microscopically, extrahepatic biliary atresia leads to this appearance in the liver, with numerous brown-green bile plugs, bile duct proliferation, and extensive fibrosis.

镜下见，肝外胆道闭锁导致肝脏大量黄绿色胆栓、假胆管增生、广泛纤维化。

Pathologic examination included: tubulointerstitial lesion which was the main pathologic presentation, tubular epithelial cell becoming flat, TEC necrosis and wither, departure between the cytoplasm and basis membrane, drops of protein in cytoplasm, broken basic membrane of TEC, inflammatory cells infiltrating in tubulointerstitium, tubulointerstitium fibrosis, plasm cell infiltration.

MM肾损害主要以小管-间质病变为主，病理表现为肾小管上皮细胞扁平，存在不同程度变性、坏死或萎缩，胞浆与基膜分离，胞浆内可见蛋白滴，甚至小管基膜断裂，间质炎性细胞浸润、纤维化，部分有淀粉样物质沉积，较少见浆细胞浸润。

Methods Hepatic fibrosis models of rabbits were made by appling abdomen walls with the cercarias of Schistosome japonica.The rabbits were randomly categorized into four groups:normal control,4,8,12 weeks after application.The level of transforming growth factor-beta1(TGF-β1) mRNA in hepatic tissues was examined by reverse transcription polymerase chain reaction. The level of expressions of Smad3 was examined by Western blot. Meanwhile,immunohistochemistry staining was assessed by measuring type Ⅰ collagen .

日本血吸虫尾蚴腹贴法制备家兔肝纤维化模型(n =32 )，按诱导时间将动物随机分为 4、8、12周及正常对照共 4组，采用逆转录多聚酶链反应检测肝组织中转化生长因子TGF -β1mRNA表达水平，免疫组织化学法检测Ⅰ型胶原的表达，同时应用Westernblot检测Smad3蛋白的表达。

Objective Pseudomonas aeruginosais a Gramnegative bacterium that colonises the lower rspiratory tract in patients with bronchiectasis,cystic fibrosis and chronic obstructive pulmonary disease.

目的 铜绿假单胞菌(Pseudomonas aeruginosa，PA)是一种定植于支气管扩张、肺囊性纤维化和慢性阻塞性肺病病人下呼吸道的机会致病菌，可持续刺激宿主免疫反应导致进展性的气道破坏，具有多重耐药的特点，一旦感染，临床治疗十分困难。

pulmonary fibrosis;herbal medicine;prevention and treating;corticoid

肺间质纤维化；中药；预防和治疗；皮质类固醇

Key words pulmonary fibrosis;herbal medicine;prevention and treating;corticoid

肺间质纤维化；中药；预防和治疗；皮质类固醇

Objective: To investigate the effects of curcumine on the expresion of leptin and leptin receptor in rats with hepotic fibrosis.

目的：探讨姜黄素对实验性肝纤维化大鼠肝脏组织中瘦素以及瘦素受体表达的影响。

These results suggest that curcumine can prevent hepatic fibrosis via inhibiting proliferation and collagen I production of HSCs, which may be partly related to its regulative effect on the expression of NHE mRNA gene.

姜黄素可能通过调控肝星状细胞NHE-1 mRNA的表达来抑制HSC的增殖及Ⅰ型胶原的合成等机制，从而抑制肝纤维化的形成。

The mechanism of this therapeutic effect of liver fibrosis will be discussed.Method:Complex factors induced-LF rats were adopted, and dimidiated into preventing and therapy groups.

本研究采用复合因素大鼠肝纤维化模型，分预防给药和治疗给药两大实验组，每组又分为正常对照、模型对照、中药低剂量、中药高剂量、阳性对照5组。

Detail Contents: Genetic disorders -- Immune deficiencies -- Breast cancer -- Colon cancer -- Melanoma -- Cystic fibrosis -- Hemophilia -- Liver disease -- Cardiovascular disease -- Muscular dystrophy -- Alzheimer's disease -- Parkinson's disease -- Huntington's disease -- Viruses: the cornerstone of gene therapy -- Viruses are living crystals -- Viral genomes may be RNA or DNA -- Viruses evolved from plasmids -- Viruses know how to infect cells -- The virus as a gene vehicle -- Viruses used in gene therapy -- Ashi DeSilva: a promising start -- Clinical trials defined -- Cells of the immune system -- Adenosine deaminase -- Preliminary research -- Clinical procedure for ADA gene therapy -- The DeSilva clinical trial -- Jesse Gelsinger: down to earth -- Ornithine transcarbamylase -- Preliminary research -- Clinical procedure for OTC gene therapy -- The Gelsinger clinical trial -- The investigation -- Concluding remarks -- Future prospects -- Safer vehicles -- Reducing immune rejection of the vector -- Improved risk assessment -- Redesigning human anatomy and physiology -- Ethics of gene therapy -- The Belmont report -- Clinical trials -- Physiological enhancement -- Cosmetic applications -- Legal issues -- Regulatory agencies -- The Gelsinger legal trial -- International regulation -- Resource center -- Eucaryote cell primer -- Recombinant DNA primer -- The human genome project -- X-linked severe combined immunodeficiency (SCID-X1)-- Alzheimer's disease -- Huntington's disease.

细节内容︰遗传疾病-免疫的缺乏-乳腺癌-结肠癌-黑瘤-囊性纤维变性-血友症-肝疾病-心血管疾病-肌营养不良-早老性痴呆病-帕金森疾病-亨廷顿疾病-病毒︰基础的基因治疗-病毒在活著水晶--病毒的基因可能是RNA或者DNA --病毒从plasmids被逐步形成--病毒知道怎样感染细胞--作为一辆基因车辆的病毒--基因治疗使用的病毒-Ashi DeSilva︰有希望开始-临床试验确定--细胞的这免疫系统-Adenosine deaminase-初步研究-临床程式给埃达基因治疗--这DeSilva临床试验-婕西Gelsinger︰到地球-Ornithine transcarbamylase-初步研究-临床程式给OTC基因治疗-- Gelsinger临床试验-调查-达成评论-前景-更安全的车辆--矢量的降低免疫的拒绝-改进风险估计-重新设计人解剖学和生理学--伦理学的基因治疗-那些贝拉蒙特报告-临床试验-生理提升-美容应用-法律问题-协调机构-- Gelsinger 合法审讯-国际管理-资源中心人物-Eucaryote信元第一-Recombinant DNA 入门--人类基因工程-- X 连结的严重的结合的免疫缺陷(SCID-X1)-早老性痴呆病--亨廷顿的疾病。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐