查询词典 fibrosis

objectiveto study the protective and therapeutic effects of the extract of retinervus luffae fructus and carapax trionyei on con a-induced hepatic fibrosis in balb/c rats.methodsthe hepatic fibrosis in rats was first induced by intravenous injection of concanavalin a, the treatment in both protective and therapeutic stage was performed by subcutaneous injection of the extract.

目的 探讨鳖甲复方中药针剂对con a在balb/c雄性小鼠中诱导肝纤维化的预防和治疗作用。方法采用con a诱导肝纤维化，造模期间及造模成功后均用复方中药针剂干预药剂组，比较组间各项血液生化指标和肝脏组织学方面的差异，以探讨针剂对肝纤维化的预防和治疗作用。

Hepatic chymase concentrations in S3 and S4 cases were greater than in S1 and S2,〔53+54=(31.3±24.6)ng/mg vs. S1+S2=(5.7±4.8) ng/mg, P.01〕. Cells immunoreactive for chymase were seen throughout portal areas and intralobular sinusoidal walls, largely colocalizing with fibrosis. Chymase appears to be involved in hepatic fibrosis in chronic hepatitis.

慢性肝炎纤维化分期重的S3和S4患者，其肝组织中Chymase浓度〔S3+S4=(31.3±24.6)ng/mg〕明显高于纤维化轻的S1和S2患者〔S1+S2=(5.7±4.8)ng/mg〕，P.01；免疫组化染色结果，Chymase标记的肥大细胞主要分布于纤维化旺盛的汇管区与类洞壁，其分布与纤维化部位相一致，且肝组织中Chymase浓度高的患者，其肝组织内Chymase标记的肥大细胞分布增多推测肝组织中Chymase浓度可能与慢性肝炎肝纤维化关系密切。

The purpose of this paper was to study the effect of Ginkgo biloba Composita on liver collagen fibrosis. The 86 patients were suffering from chronic persistant and active hepatitis B with early fibrosis confirmed by liver biopsy.

应用复方银杏叶冲剂治疗86例慢性乙型迁延性和活动性肝炎早期纤维化患者，疗程3个月，以血清层粘连蛋白、血清Ⅲ型前胶原肽、超氧化物歧化酶、丙二醛及部分光、电镜活检为指标。

Establishing experimental animal model of immunized fibrosis could contribute to research on extracellular matri and cytokine. they turns out that the ingredient of Desmodium pulchellum can relieve extra growth and deposit of ECM and adjust the level of relative cytokine, such as TGF-β1 and IFN-γ, benefit to effect of hepatic anti-fibrosis.

结果证明排钱草生物碱类成分能减轻肝纤维化的基本病理改变即减少肝细胞外基质的过度增生和沉积，调节与肝纤维化密切相关的TGF-β1、IFN-γ等细胞因子水平，向着有利于减轻肝纤维化的方向发展。

Theurinary IL-6 level positively correlated with density of glomerular matrix membrane, global sclerosis, fiber or fibrocellular crescents and interstitial fibrosis (p. 05). According to the degree of density of glomerular matrix membrane and interstitial fibrosis, urinary Col-IV level had better correlation than urinary TGF-betal and IL-6 levels.In IgAN, Col-IV showed increased expression in diseased renal tissue whereas the site of expression of TGF-betal was mainly localized within the cytoplasm of tubular epithelial cells. Interstial expressionwas also present but glomerular TGF-betal expression was found only in patients with heavy mesangial proliferation. There was a significant correlation between glomerular positivity for Col-IV and severity of histological damage. There was also a significant correlation between positivity for TGF-betal and Col-IV in the tubular epithelial and interstitial lesions. In contrast, there was no ralationship between glomerular positivity for TGF-betal and severity of histological damage.The urinary TGF-betal level paralleled tubular TGF-betal expression.

结果 ①IgAN患者尿TGF-β1、IL-6、Col-Ⅳ水平较健康人明显增高(P＜0.01)，该变化与血中的浓度无关(P＞0.05)；②尿TGF-β1水平与小管间质TGF-β1阳性表达呈正相关(P=0.000)，而与小球TGF-β1阳性表达无关(P＞0.05)，尿Col-Ⅳ水平与小球和小管间质Col-Ⅳ阳性表达均呈良好的相关性(P＜0.01)，还与小管间质TGF-β1阳性表达呈正相关(P＜0.05)：③小球Col-Ⅳ阳性表达与肾组织慢性病变密切相关(P＜0.05)，小管间质Col-Ⅳ和TGF-β1阳性表达均与肾小管间质病变呈良好的相关性(P＜0.01)，而小球TGF-β1阳性表达与肾组织损伤无关(P＞0.05)；④尿TGF-β1、Col-Ⅳ水平与肾小球基质基底膜面密度、小管间质病变呈正相关(P＜0.01)，与小球内细胞数呈负相关(P＜0.05)，该结果与其在组织中的表达一致；尿IL-6水平浙江大学硕士学位论文尿TGF一B一、IL一6和Col一IV在IgA肾病中的应用价值与基质基底膜面密度、球性硬化、纤维或细胞纤维新月体所占肾小球百分数及小管间质病变均有显著的相关性(F.05)；在轻度肾病理损伤时，尿'l'G卜pl、I卜6、Col一IV水平即升高，而尿Col一W在反映细胞外基质积聚和间质纤维化程度上比尿TGF一pl和IL一6有更好的相关性。

Results: Compared with sham controls, a progressive hyalinization and thicked wall of coronary arteries; perivascular fibrosis and interstitial fibrosis were observed in SAD rats.

结果：与Sham组相比，SAD大鼠心肌内冠状血管管壁呈进行性增厚、玻璃样变，管腔狭窄，血管周围纤维化和间质纤维化，心肌细胞肿胀、坏死和炎细胞浸润。

Results CsA clearly decreased creatinine clearance and increased urinary excretion of N-acetyl-β-D-glucosaminidase in rats as compared with those in the vehicle group. Morphologic changes consisted of vacuolization of tubular cell, expansion of the interstitium and interstitial fibrosis, hyalinization of afferent arterioles. Severity of the injury was related to the dosage of CsA. Striped interstitial fibrosis and arteriolopathy were more severe in the rats treated with CsA and low-salt diet than with CsA and normal diet.

结果 用CsA的大鼠出现尿量增多、内生肌酐清除率下降、尿N-乙酰-β-D-氨基葡萄糖苷酶排泄增多等；病理上表现为不同程度的细胞浊肿、空泡变性及灶性分布的间质纤维化和小动脉病变，随CsA剂量的增加，病变呈加重趋势；结合低钠饮食，CsA慢性肾毒性病变明显加重。

Although the pathogenesis is not very clear, new understandings about development of pulmonary fibrosis has appeared in company with impenetration of cell biology research and molecular biology research. In a word, research of pulmonary fibrosis gradually appears to be integrated and multidisciplinary crossover.

尽管肺纤维化发病机制目前尚不完全清楚，但随着细胞生物学和分子生物学研究不断深入，对肺纤维化的发生、发展机制有了许多新得认识，肺纤维化机制的研究正逐渐走向整体化和多学科交叉方向。

Objective: To explore the effect and happening mechanism of hdrochloric acid kukoline for the treatment of renal interstitial fibrosis,to supply some according for clinic how to resist glomeruli and nephric tubule interstitial fibrosis.

目的：探讨盐酸青藤碱在治疗肾间质性纤维化中的作用及其发生机制，为临床如何阻止、防止肾小球和肾小管间质纤维硬化提供借鉴。

P=0.002 .(2) Histological results demonstrated: the large area of fibrosis of cartilage could be seen in the medial condyle at 26 weeks; the fibrosis was deep into the deep layer of cartilage and the number of cells decreased; the average Mankin's score was 7. 7, which significantly increased with that in controlled group.

2后交叉韧带切断后26周内髁软骨可见范围较大的软骨纤维化现象，深达深层，细胞数量减少，Mankin评分平均7.7，和对照组同期相比有明显的统计学意义（Hc=8.486，P=0.004）。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐