查询词典 fibrosis

Abstract］ Objective To study the effect of zinc protoporphyrin,an inhibitor of heme oxygenase-1（HO-1）,on pathological and pathophysiologic changes of rat pulmonary fibrosis induced by bleomycin,and to investigate the role of Znpp in the pathogenesis of pulmonary fibrosis.

目的 观察血红素加氧酶-1（HO-1）抑制剂锌原卟啉对博莱霉素致大鼠肺纤维化模型病理和病理生理改变的影响，探讨Znpp在BLM诱导肺纤维化发病中的作用。

It is indicated that the direct kidney electrotransfer of hHGF gene was effective in preventing renal function injury and interstitial fibrosis of the transplanted kidney. It is relation of transfection of hHGF gene into the rat renal with reimplantation of the kidney suppressed tubulointerstitial injury and subsequent fibrosis in context of induced inchemia.

hHGF基因转染治疗对减轻移植肾的肾功能损伤和肾间质的纤维化具有远期效果，这种远期效果可能与hHGF基因对移植肾早期缺血再灌注损伤的保护作用及抗纤维化作用有关。

matrix metalloproteinase; fibroblast cells; pulmonary fibrosis; silicotic fibrosis

基质金属蛋白酶；肺间质成纤维细胞；肺间质纤维化；矽肺

Methods:Establish the model of myocardial fibrosis in chronic stage of viral myocarditis by injecting CVB3 into Balb/c rats,divide these rats into model group、Tong xin luo low dose group、Tong xin luo medium dose group、Tong xin luo high dose group and set up normal group,after four weeks of giving medicine execute the animals and observe the ultrastructure of myocardial cell with tramission electron microscope,the quantity of myocardial collagen was observed by staining with H.E and Sirus red in supersaturated picric acid solution;the amount of HA in serum was measured with the method of radiative immunity;the quantitative expression of fibrosis factor—TGF、PDGF was measured with the method of immunity histochemistry.

腹腔注射柯萨奇B3病毒建立病毒性心肌炎慢性期心肌纤维化小鼠模型，随机分为模型对照组、通心络低剂量组、中剂量组、高剂量组，并设正常对照组，用药四周后处死动物通过透射电镜观察心肌细胞超微结构；HE染色、苦味酸天狼星红染色观察心肌胶原数量；放免法测定血清透明质酸的含量；免疫组化染色观察致纤维化细胞因子—转化生长因子和血小板衍生生长因子的定量表达。

In this article, we used automotive immunohistochemical stainer to check the expressions of HBsAg and HCV antigens in 100 cases of HCC and their adjacent tissues, mean while, we checked their histological activity index and hepatic fibrosis degree. We also used radioimmunoassay to detect serum levels of 4 serum fibrosis markers and serum AFP levels in these cases. Immunofluorescence labeling and flow cytometry were used to check the T-cell subpopulations and the activity of NK cells of these 100 cases. Then the correlations among these factors were studied.

本文采用全自动免疫组化仪对100例肝癌组织及癌旁组织中的HBsAg、HCV抗原表达进行了标记，同时对其进行肝组织活动指数、纤维化分期；同时采用放射免疫测定方法检测同期血清透明质酸、Ⅲ型前胶原蛋白、层粘连蛋白和Ⅳ型胶原蛋白等四项血清肝纤维化标志物和血清甲胎蛋白水平；采用免疫荧光标记技术和流式细胞仪对T细胞亚群及NK细胞活性测定，对各项指标的相关性进行系列对比研究。

Liver fibrosis/physiopathol; liver fibrosis/tcm ther;liver/pathol;achillea alpina/pharmacol;plant extracts/pharmacol;plant extracts/admin;rats

肝纤维化/病理生理学；肝纤维化/中医药疗法；肝/病理学；蓍草/药理学；植物提取物/药理学；植物提取物/投药和剂量；大鼠

Early intervention with QZHJ could inhibit the secretion of IL-8 and TGF-β1 and prevent the development of alveolitis and fibrosis of lungs in bleomycin - induced pulmonary fibrosis rats.

早期应用芪术合剂可抑制IL-8和TGF-β1的产生，从而预防和阻止实验性大鼠肺纤维化的形成。

Results (1) The degrees of alveolitis and pulmonary fibrosis of the model group was increased remarkably on day 7,14,28 compared with the control group (P.05), The expression of TNF-α, TGF-β1, FN protein of model group on day 7, 14, 28 was remarkably increased compared with the control group (P.05);(2)The degrees of fibrosis and the expression of TNF-α, TGF-β1 , FN protein are decreased significantly in Group B compared with Group A( P.05) but not significantly in Group C.

结果：(1)模型组肺泡炎、肺纤维化程度都明显重于对照组，肺泡炎、肺纤维化第7、14、28d差异显著(P＜0.05)；TNF-α、TGF-β_1、FN蛋白表达明显上调(P＜0.01)；(2)治疗组B组第7、14、28d肺泡炎、肺纤维化程度较模型组明显减轻，TNF-α、TGF-β_1、FN蛋白表达明显下调(P＜0.05)：(3)治疗组C组第28d肺泡炎、肺纤维化程度与模型组相似，TNF-α、TGF-β_1、FN蛋白表达与A组比较无统计学意义(P＞0.05)。

These results suggested that the lung Fib were activated and produced excess HA, resulting in the excessive accumulation of HA within the lung at the stage of alveolitis during the process of pulmonary fibrosis. However, increased HA synthesis of lung Fib and increased HA levels in BALF merely reflect the intensity of alveolitis and the disease activity rather than the degree of pulmonary fibrosis.

以上结果提示：肺Fib在肺纤维化的早期肺泡炎阶段就处于活化状态，产生HA增多，导致肺内HA的过多聚积，肺Fib产生HA增多和BALF中HA水平的增高可反映肺泡炎的强度和疾病的活动性，但并不能反映肺胶原代谢或纤维化的程度。

Objective: To investigate the activity of coagulation and fibrinolysis systems in bronchoalveolar lavage fluid in lung fibrosis in rats, and to study their role in diagnosis of lung fibrosis.

目的：测定肺纤维化大鼠支气管肺泡灌洗液中凝血及纤溶指标的水平，探讨其在诊断肺纤维化中的作用。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐