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2The distribution of HIF-1 a and COX-2 was unequal;.(3)These findings indicate that HIF-1a and COX-2 may be two important factors in pulpal lesions and there is a significantly hypoxia condiction in inflamed pulp .(4)The increase of HIF-1 a is a possible mechanism for hypoxia preconditioning .(5)Our results suggested that pulpal fibroblasts as well as macrophages might be involved in the pathogenesis of irreversible pulpitis.

和COX一2的表达均有不同程度的变化，在牙髓炎病程中可能发挥着重要的生理和病理作用，③在牙髓炎进程中和牙髓自身修复过程中存在着缺氧环境和缺氧耐受机制，④牙髓成纤维细胞有可能与单核巨噬细胞一同参与牙髓炎的病理进程，且具有修复和免疫功能。

Objective To investigate the best method of culture conjunctival epithelial cells and fibroblasts in vitro , and further more to provide a foundation for investigating its biologic feature and reconstruction.

目的 探讨体外培养兔眼结膜上皮细胞和成纤维细胞的最佳方法，为进一步研究结膜的生物学特性和结膜重建提供基础。

AIM: To investigate the effects of dibairen decoctum on the proliferation of keratinocytes and fibroblasts as well as the potential effects of DBRD on fibroblast contraction.

目的：观察地白忍煎剂对角朊细胞和成纤维细胞增殖的影响以及对成纤维细胞收缩功能的潜在作用。

BACKGROUND: Chondrocytes in vitro cultured with traditional culture methods tend to dedifferentiate into fibroblasts through long-term serial subcultivation, which results in a terrible decrease in the number and activity of cells.

背景：传统培养方法体外培养的软骨细胞经长时间传代培养后往往去分化为成纤维细胞，导致细胞数量及活性下降。

Compaired with normal skin tissues, HGF/c-met expression was up-regulated in hypertrophic scar tissues in dermic fibroblasts.

HGF/c-met在真皮层表达水平的改变可能是影响人增生性瘢痕形成的重要因素。

The cooperation of 8-MOP/UVA could induced dermis of the non- lesion back skin of vulgar psoriatic patients and the cultured dermic fibroblasts produced large aging-associated mutations of mtDNA rapidly, it is feasible to establish human models in vivo and in vitro which could produced large aging-assoiated mutations of mtDNA rapidly for studies of the mechanisms of mutations of mtDNA in skin photoaging.

2.8-MOP/UVA可诱导寻常型银屑病患者背部非皮损区真皮组织及培养的成纤维细胞迅速产生光老化相关的mtDNA突变，建立迅速产生光老化相关mtDNA突变的体内外模型，利用该模型进一步研究mtDNA突变在光老化皮肤中的产生机制及其在皮肤光老化形成中的作用是可行的。

However, the molecular mechanisms underlying premature aging up 8-MOP/UVA are as yet unknown. In our studies, dermis of the non-lesion back skin of vulgar psoriatic patients who had been treated by PUVA and the cultured foetus dermic fibroblasts were selected to be observed.

本课题以PUVA治疗寻常型银屑病患者背部非皮损区真皮及培养的胎儿真皮成纤维细胞为对象，采用HE染色、Verhoeff染色、电镜、酶组织化学、免疫组织化学、原位杂交、流式细胞计数仪、三引物PCR、PCR-SSCP技术及PCR产物直接测序等技术和方法，研究了8-MOP/UVA对皮肤光老化形成的影响及芳维A酸乙酯的拮抗作用。

Disodium cromoglycate can inhibit slightly the proliferation and collagen synthesis of hypertrophic scar fibroblasts in vitro .

本实验浓度组的色甘酸钠在体外对瘢痕成纤维细胞的增殖和胶原合成抑制作用有限。

Adding dividedly the solution of two drugs with different concentration into the heperplastic scar fibroblasts and keloid fibroblast which were in logarithmic growth phase. After 48 hours in vitro culture, hydroxyproline colorimetric test was conducted, then statistics comparison was carried out in accordance with hydroxyproline content which was calculated based on OD value.

向对数生长期的增生性瘢痕成纤维细胞及瘢痕疙瘩成纤维细胞中加入不同浓度的两种药液，培养48小时后进行羟脯氨酸比色试验，并将 OD 值依公式换算成羟脯氨酸含量，进行统计学比较。

However, another investigation12 using the immunolocalization of MMP1, MMP2, MMP9, and MMP14 (MMP14 is a membrane-bound MMP) showed elevated levels of MMP2 and MMP14 in macrophages, as well as in the type II cells and fibroblasts, in emphysematous, compared to nonemphysematous, tissue.

但是在另一项对MMP 1，MMP 2和MMP 14（MMP 14 为有膜MMP）的免疫定位的研究中发现，气肿性组织较非气肿性组织而言，巨噬细胞中的MMP 2与MMP 14水平有升高，II型细胞和层纤维细胞亦如此现象。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐