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Method]Isolated bMSCs were cultured in vitro. rh Fibroblast Growth Factor 1(rhFGF-1)、rh Transforming Growth Factor-β1(rhTGF-β1)、rh Insulinlike Growth Factor-Ⅰ were utilizated. The proliferation of cells was detected by MTT assay, and the macroscopic histology , HE staining and immunohistochemical examinations were performed to seek the best cell factor. In vivo , to investigate the repair of the articular cartilage, bMSCs combined with fibrin glue and rhTGF-β1、rhIGF-I was compared with control group.

方法]rhFGF1、rhTGF-β1、rhIGF-I单独或联合应用对骨髓基质干细胞进行体外诱导培养,应用常规染色、MTT、免疫组织化学染色的方法筛选诱导骨髓基质干细胞成软骨细胞的最佳细胞因子,并将其与骨髓基质干细胞复合于纤维蛋白凝胶制成凝胶复合物,直接种植到兔膝关节实验性关节软骨缺损处,并与对照组相比较,观察软骨修复效果。

Since July 2007, we have found that haemophilia's main treatment drug, Factor VIII concentrate and prothrombinase complex, is in dangerously short supply. Since July 5, even the Institute of Hematology and the Chinese Academy of Medical Science's Blood Disease Hospital have lacked supplies of Factor VIII. Many haemophiliacs cannot get timely and efficient treatment in hospitals, plunging them into a crisis. Without Factor VIII, their lives are in danger. The lack of Factor VIII has already caused the deaths of

从2007年7月以来,我们发现专门用于治疗血友病的凝血八因子和凝血酶源复合物供应非常紧张,从7月5日开始,连中国医学科学院血液病医院都出现断药,许多血友病患者去医院看病都无法得到及时有效的治疗,致使病情加重,生命垂危,一些城市相继出现病人因此死亡的情况。

Secondly, the power system fault diagnosis analytic model which use both protect andswitch action information is proposed in this paper, it can be described as 0-1 integerprogramming with nonrestraint, reshut break is introused in the analytic model and introducethe contribution factor to the protect, this model solve the fault diagnosis problem in which theprotect information is lack in a certain extent, and present the experienced formular which isused to decide all kinds of protect contribution factor.

然后,提出同时利用保护和断路器动作信息的电力系统故障诊断的解析模型,其可以描述为一个无约束 0-1 整数规划问题,将重合闸引入故障诊断的解析模型并且对保护引入贡献因子,给出确定各种保护贡献因子的经验公式。这种模型在一定程度上解决了数据信息不完整时的电力系统故障诊断问题。

Chapter 9 is conclusion and future prospect. There are five innovative findings in the paper. Firstly, the evolvement of extensions and connotations of two reengineering styles is analyzed based on their high risk, and finding their trends of amalgamation. With this, the concept of corporation reengineering is then redefined combining core competence theory and ideas of process change management, and decompounding it into two parts: pre-reengineering and post-reengineering. Its inner relationships are analyzed and explained by economics theory. Secondly, establishing a analysis framework of reengineering risks, risk factors of foreign BPR are analyzed and concluded systematically for the first time. Reengineering risks are divided into three parts: plan, design and executive based on process and project management, then risk factors system is abstracted. Thirdly, 72 reengineering corporations in Jiangsu province are investigated on risk condition. Furthermore, risk factors in every part are analyzed and reduced experimentally by factor analysis method, and a risk factors system to suit Chinese corporation's reengineering is established. Fourthly, setting up a choice model of reengineering projects, the objective optimization model is presented to ascertain the weigh of each factor, a method of sequencing reengineering projects is presented so that risk of each reengineering project can be evaluated and compared effectively. Fifthly, an integration relationship model among IT, BPR and strategy is established aiming at productivity paradox derivative from IT and its dual effects on BPR, IT investment priorities in BPR is narrated deeply.

本论文的创新点体现在五个方面:1)基于上述两种重组方式的高风险性,对它们的外延和内涵演变进行了分析,发现它们日益融合的趋势;然后结合核心能力理论和流程变革管理的思想对企业重组的概念进行了界定,将其分为&前重组&和&后重组&两部分,并对其内部关系进行了详细分析,同时应用经济学理论对其进行了解释。2)建立了重组风险的分析框架,并首次较为全面地分析和归纳了国外企业重组的风险因素,根据重组的过程和步骤以及项目管理的观点,将重组风险划分为计划、设计和执行3个部分,并在此基础上提炼出企业重组的风险指标体系。3)运用现场访谈、问卷调查的方法,调查了江苏省72家企业重组的风险情况,然后利用因子分析法对每一部分的每一风险因素进行实证分析,对风险指标进行了约减,建立了比较完善的适合我国企业的重组风险指标体系。4)建立了重组变革方案的选择模型,然后针对不同的重组方案提出了确定指标权重的目标优化模型,并基于三角模糊数之间两两比较的可能度概念,提出了一种重组方案排序法,从而可以有效地对各种变革方案的风险进行评估和比较。5)针对信息技术所造成的&生产率悖论&现象及其对重组的双重影响,建立了信息技术、企业重组和企业战略之间的整合关系模型,并对重组中信息技术投资的优先权问题进行了深入的阐述。

Twenty-four hours after the last oral administration, the blood were obtained and used for testing adrenocorticotrophic hormone, cyclic adenosine monophosphate, cyclic guanosine monophosphate, glucose, cholesterol, alanine aminotransferase, urea nitrogen. Results Before taking medicine, model rats' cAMP/cGMP and ACTH were lower than normal rats', and they showed a trend of rise with adding dose. Before taking medicine, model rats' GLU was lower than normal rats'. With adding dose, model rats' GLU increased, however, normal rats' GLU reduced. When taken medium dose white prepared lateral root of aconite, model rats' CHO was higher than normal rats'. Taking medicine made both groups ALT rise, but normal rats' went up more quickly than model rats'. Model rats' BUN was higher than normal rats', and taking low dose or little dose medicine could lead to incline of reduction.

结果 给药前模型组环磷酸腺苷/环磷酸鸟苷和促肾上腺皮质激素低于正常组,随着给药剂量的增加,两者有升高的趋势;给药前模型组血糖低于正常组,随着给药剂量的增加,模型组GLU有升高的趋势,而正常组有下降的趋势;中剂量给药时模型组总胆固醇显著高于正常组;随着给药剂量的增加,2组丙氨酸氨基转移酶均有升高的趋势,且正常组ALT升高的幅度更大;给药前模型组尿素氮高于正常组,低、小剂量给药有降低模型组BUN的趋势。

In the light of the complex, high-level and non-linear feature of the mathematical model which describe the transport of the coalbed methane, this paper study the fully-implicit solving method of the mathematical model in detail. Based on the complexity of the algebraic equations which are formed eventually, according to the alternating direction implicit difference pattern, this paper use the iterative method and the fully main element Gauss-Jordan eliminating method to solve equations, which is to use the iterative method to determine coefficient matrix and use the fully main element Gauss-Jordan method to solve th linear algebraic equation group, at the same time of studying the solving method of the mathematical model, according to the devising requirement of FORTRAN77 program structure, this paper draw up computer program and form the corresponding computer model, and verify the validity and reliability of the model in theory by operating the model.

重点研究了模型内、外边界及有关参数的处理,针对描述煤层甲烷运移的数学模型是一个复杂、高阶非线性数学模型的特点,详细研究了模型的全隐式求解方法,根据最后形成的代数方程组的复杂性,按交替方向隐式差分格式,采用迭代与全选主元高斯约当消去法相结合的方法求解方程:即确定系数矩阵采用迭代法,求解线性方程组时采用全选主元高斯约当消去法,在研究模型解法的同时按FORTRAN结构化程序设计的要求,编制计算机程序,形成相应的CBMRS计算机模型,并通过模型的运行从理论上证明了模型的正确性与可靠性。

Main contributions and achievements are as follows:A general non-equilibrium rigorous model for RDP is developed in this thesis. Based on the pseudo-homogenous assumption, two main factors reaction and separation are de-coupled, and an RDP model with the same format as that for a traditional distillation process is established. To solve the model with a large number of algebraic equations, modified M-K equations with tri-diagonal matrix form are developed based on the improved Separation Efficiency Functions, which greatly increases the iteration efficiency. This thesis also develops a general reactive distillation dynamic model. Through splitting of the differential variables based on SEFS, large-scaled differential algebraic equations can be solved with the improved Gear's algorithm which makes the dynamic model suitable for the on-line application. A simulation platform for the control loop design and evaluation of RDP by introducing control system equations into the dynamic model is also developed.A lactic acid purification pilot-scale RDP is investigated.

论文对热点问题——反应精馏过程的建模与优化控制相关技术进行了深入的研究,取得了一系列成果:1、建立了反应精馏过程机理模型,基于拟均相假设,将反应和分离过程进行解耦,推导出反应精馏过程的非平衡级稳态模型和动态模型,通过引入推广的分离效率函数,对模型变量进行了合理划分,显著提高了模型求解效率;将动态模型和控制系统方程结合,建立了反应精馏过程控制系统研究的辅助工具。2、全面分析了乳酸提纯反应精馏新工艺试验装置,利用本文建立的过程机理模型,对该试验装置进行了稳态和动态性能分析及水力学核算;设计和分析了单边质量控制方案,比较了间接和直接物料平衡控制两种方案的控制性能。

First discarding the thought of fitting by AR model, the ARMA model is fitted by a high order MA model using Gevers-Wouters algorithm on the basis of related functions of ARMA model. Then according to the parameters of the fitted MA model, the ARMA model parameter estimation through solving a system of antipathic linear equations using the least squares method is obtained.

首先摈弃传统的拟合到AR模型的思考方法,而是基于ARMA模型的相关函数用Gevers-Wouters算法对ARMA模型拟合到高阶滑动平均模型;然后在拟合的MA模型参数基础上,用最小二乘算法求解一个不相容的线性方程组,从而估计出ARMA模型参数。

Based on the analysis of the mechanism of robot manipulators, a trajectory tracking controlling research model is first built up with ADAMS, and its mathematical model is formulated through the study of robot kinematics and dynamics. After the modeling errors are analyzed in practical robotic systems, a conception of centralized error is brought forward according to the theory of weighting functions. In the case of modeling errors' exist, the robotic uncertain model is derived by introducing an auxiliary control variable into inverse dynamic analysis. The control strategy of robust exponential convergence is applied to the robotic uncertain model, the applicable conditions and the applicable controller with this application are presented. The stable control effect under three main model uncertainties (parametric errors, joint disturbs, joint frictions) are systematically studied on the previously built research model. The problems of robust exponential convergence controller which often results in unstable output and so produces a large relative error when the input trajectory is in a small range are resolved by adjusting the control parameters based on the controller's structure.

本文在机械手的机械结构分析基础上,利用ADAMS建立了用于机械手轨线跟踪控制研究的机械手模型;通过对机器人运动学和动力学问题的研究,建立了机械手研究的数学模型;分析了机器人系统中模型误差的主要来源,根据加权函数法分析,提出了模型集中误差的概念;在存有模型误差的情况下,采用逆动力学结构并引入辅助控制量,由机器人误差模型推导了机器人非确定性模型;提出了采用鲁棒指数收敛法对上述机器人非确定性模型进行鲁棒镇定的控制策略,并给出了对机器人进行鲁棒指数收敛控制时系统不确定因素应满足的匹配条件;针对机械手研究模型,深入研究了鲁棒指数收敛控制器对机器人系统中常见的模型参数误差、关节扰动、关节摩擦等不确定因素的镇定控制效果;针对鲁棒指数收敛控制器易产生控制量振荡的问题以及在小范围内系统轨线跟踪的稳态误差过大问题,本文分别提出了基于控制器结构的控制参数调整法和基于轨线跟踪范围大小的控制参数分段切换法。

It is proved that the model of Hertz, Capon and Lindel"of areidentical to Vakonomic model while the model of H"older, Pars andChaplygin are identical to Chetaev's model. The fact thatVakonomic model and Chetaev's model exist simultanously can betraced back to the early days of non-holonomic mechanics. These twomodels cause two problems the d- and - permutable problems.

论证了Hertz, Capon和Lindel"of的工作与Vakonomic模型相吻合,而H"older, Pars和Chaplygin的工作与Chetaev模型相吻合,Vakonomic模型和Chetaev模型两类模型并存的局面可以追溯到非完整力学发展的初期。1mm说明了伴随两类模型并存的现象而出现的两个问题 d-交换性问题和-交换性问题。

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推荐网络例句

In the days of sailing vessels the crew were afraid they would be becalmed on the ocean.

在使用帆船的时代,船员们担心他们会因为无风而无法在海洋上航行。

As long as foreign donors pay the PA's salary bill, few expect a new intifada.

只要外国继续为巴权力机构的薪水买单,希望发动新暴动的人便寥寥无几。

Speak with contempt of none,form slave to king,the meanest bee,and will use,a sting.

别用 言词贬低任何人,无论国王还是奴隶。最卑戝的蜜蜂也会用它的毒针蜇人。