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However, fully consideration of special structure and physiological function of CRP is critical to investigate whether CRP provide protect effect or pathogenic effect in the progression of atherosclerosis. CRP is a member of pentrxins family, which consists of five identical, noncovalently associated 23-kDa protomers arranged symmetrically around a central pore with a 102 A external diameter. Each protomer has a recognition face with a phosphocholine binding site consisting of two coordinated calcium ions adjacent to a hydrophobic pocket. The opposite face of the pentamer is the effector face, where complement Clq binds and Fc receptors are presumed to bind. A cleft extends from the center of the protomer to the central pore of the pentamer. Both faces ofpentamer form a special bi-phase structure: one face is the ligand recognition phase, which can recognize apoptosis cells and enzyme modified low density lipoprotein in which PCh is exposed.

CRP是一种五聚体蛋白，外径为102 A，由5个相同的单体以非共价键结合，形成双面的环形结构，每个单体的配体识别位点或受体结合位点分别位于五聚体两个平面上，分别组成配体识别相和效应器相，从而构成特殊的二相性结构：一面为配体识别相，含有磷酸胆碱(phosphorycholine，PCh)结合位点，能够使CRP识别在病理条件下暴露出PCh的凋亡细胞、酶修饰低密度脂蛋白(enzyme modified low density lipoprotein，E-LDL)等。E-LDL是天然低密度脂蛋白(native Low density lipoprotein，N-LDL)在多种蛋白酶，如胰蛋白酶、神经氨酸酶、胆固醇酯酶等作用下的代谢产物，其主要特点是结构发生改变(N-LDL大小均匀，平均直径250±30 A，E-LDL大小差异极大，直径为100-2000 A)，暴露磷酸胆碱位点，能够被CRP识别；另一面为效应器相，能够与巨噬细胞、单核细胞表面受体FcγRⅡa结合，介导巨噬细胞、单核细胞识别及吞噬凋亡、坏死细胞作用。

At the same time, using " the principle of near discipline analogized ", separately to planning to select site and building internal and external space form two major module of professional wholesale market, it carries on comparatively deep research and hopes to offer feasible reference and suggestion for further construction practice.

同时，运用&邻近学科类比法&，分别对专业批发市场的规划选址、建筑内外空间形态两大模块进行深入的研究，希望能为进一步的建设实践提供切实可行的参考和建议。

Internal and external warfare are simply opposing polarities of the same thought-form of destruction.

内在和外在战争只是同一破坏性思想形态的两种相对极性。

If an external hemorrhoid becomes strangulated, a clot can form in it and be an excruciatingly painful thrombosed hemoroid.

如果外部痔成为绞，一个可以形成血块在它是一个极其痛苦的血栓hemoroid 。

When the external of man's nature subjugates the internal, dark storm clouds begin to form.

一旦人的外部世界征服了内部世界，黑暗的乌云就会开始形成。

When the external of man's nature subjugates the internal, dark storm clouds begin to form.

一旦人性中的外在力量胜过了内在力量，乌云暴雨便会开始形成。

The proposed framework has a strong significance in real practice. In part 4, in the terms of mushrooming new marketing methods, the paper applied them into city marketing. First, by studying state marketing, the part reminded city marketers to pay attention to the external policy environment for city marketing. This part focused on the method that helps city to develop by taking advantages of state marketing. Second, this part reminded city marketer to pay attention to the internal citizens environment, by focusing on the method that helps the city to form a composition of forces, which is taking advantages of social marketing, and conforming city value concepts. Third, by studying experience marketing, this part reminded city marketers that pay attention to the psychological factors of city customers in city marketing, focusing on the methods that strengthen the city attractiveness, which is taking advantages of experience marketing, and subliming the inner experience of city customers.

第四部分，将近年来涌现出的新营销方法应用于城市营销之中，首先，通过对国家营销的研究，提出不可忽略城市营销中的外部政策环境，重点研究了城市营销如何借国家营销之大势，得以借力发展的方法；其次，通过对体验营销的研究，提出不可忽视城市营销中的&城市顾客&心理因素，重点研究了如何借体验营销之递进，使&城市顾客&逐步对城市产生归属感，从根本上增强城市吸引力；第三，通过对社会营销的研究，提出不可忽视城市营销的内部环境，重点研究了如何借社会营销之内力，统一城市价值观，形成城市营销合力。

First, we consider nonholonomic chained systems with modeling error, in this section,based on back-stepping , using the so-called adding a integrator , state-scaling technique , we design discontinuous feedback law,such that the trival solution of the closed-loop systems global strong stable; Second,we consider high-order nonholonomic chained systems with modeling errors and external disturbances, in this section,using input/state-scaling and integrator backstepping methods , we design discontinuous feedback law and give out the switching strategy, such that the closed-loop systems global /C-exponential stable; Finally, we consider a class of more general power chained form systems with particular drift-terms, in this section , using Lyapunov method, we design time-varying feedback law , such that the closed -loop systems p—exponential stable.

第一部分考虑的模型为带有模型误差的高阶非完整链系统，我们运用加幂积分器、State-scaling技巧以及基于Back-stepping方法构造出不连续反馈律，从而使得所讨论系统的闭环系统的平凡解全局强稳定；第二部分考虑的模型为带有模型误差的不确定高阶非完整链系统，这一部分我们运用input／state scaling和integrator backstepping方法构造出不连续反馈律，并给出切换策略，使得所对应的闭环系统全局κ-指数稳定；第三部分考虑的系统是形式更为一般的且带有特殊形式漂移项的幂链系统，利用Lyapunov函数方法，设计出时变反馈律，从而使得相应的闭环系统ρ-指数稳定。

Regardless of their mix of on-site and off-site activities or their use of work done by external accountants, banking supervisors usually have regular contact with bank management and a thorough understanding of the institution's operations. This may take the form of prudential meetings held between supervisor and bank, and/or tri-party meetings held among supervisor, bank and the bank's auditor to discuss regularly all significant issues and areas of their business.

无论实行现场监管与非现场监管的结合还是由外部会计师审计，监管人员通常会与银行管理人员保持经常的联系，并深入了解金融机构的经营情况，这可以通过监管人员和银行之间的审慎会谈，或者通过监管者与银行以及银行的审计师三方会议来进行，对所有重要的问题和业务展开定期讨论。

First of 3 external frames that form the building cradle being moved into position.

首先3外部框架，形成了建设摇篮正在进入立场。

Singer Leona Lewis and former Led Zeppelin guitarist Jimmy Page emerged as the bus transformed into a grass-covered carnival float, and the pair combined for a rendition of "Whole Lotta Love".

歌手leona刘易斯和前率领的飞艇的吉他手吉米页出现巴士转化为基层所涵盖的嘉年华花车，和一双合并为一移交&整个lotta爱&。

This is Kate, and that's Erin.

这是凯特，那个是爱朗。