查询词典 exotoxin

Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae that has been lysogenized by β bacteriophage that carries the DT gene.

白喉毒素是棒状白喉杆菌被β噬菌体感染后分泌的一种外毒素。

Sequence encoding Pseudomonas exotoxin A translocating peptide was localized between antibody gene and GrBa gene.

表达的immunoGrB蛋白进入肿瘤靶细胞的内吞小体后，发生Arg279和Gly280之间肽键的定点裂解，裂解后的PE Ⅱ-GrBa被转位到细胞质中。

According to this, we take the lead in putting forward the new strategy possessing original innovation and independent intellectual property which is by using molecular design and expression of brand new types of B7PE40KDEL recombinant exotoxin fusion proteins to specifically prevent GVHD or HVG Effect.

据此，我们率先在国际上提出了分子设计并研创全新型系列重组人B7-PE40KDEL外毒素融合蛋白以达到特异性防治GVHD和HVGD，诱导免疫耐受的新思路。

Although botulinum A exotoxin is a safe agent commonly used in dermatology to treat wrinkles, patients sometimes report discomfort or headaches following injection.

尽管A型脑肠菌毒素是一种安全的药物，常用於皮肤科来消除皱纹，但是一些报告显示，有的患者有时在注射后会出现不适或头痛。

The key point for constructing the novel recombinant exotoxin fusion protein B7-PE40 KDEL was to preserve the molecular biology characteristics of themselves, such as flexibility, antigenicity, hydrophilicity, epitope and secondary structure and to enhance their cytotoxic activity.

分子构建成功新型重组B7-PE40KDEL融合蛋白的关键在于，要使所构建的B7-PE40KDEL能分别保留B7-1、B7-2和PE40KDEL各自的表位特征、没有新的抗原表位产生、柔性接头处具有极低的抗原性以及具有更强的杀伤效力。

Methods Three-dimensional gels of type I collagen containing rabbit keratocytes were incubated in the presence of different concentrations of exotoxin A (0.1,1.0,10 mg·L-1),cultivated for 24 h at 37℃, the change of keratocytes in morphology was observed under the light microscope,and the amount of lactate dehydrogenase was measured by enzyme linked immunosorbent assay.

含兔角膜基质细胞（1×105·mL-1）三维胶原凝胶表面添加提纯的不同浓度绿脓杆菌外毒素A（0.1、1.0和10 mg·L-1）后，放入无血清MEM培养液中37℃培养24 h，采用光学显微镜观察培养的兔角膜基质细胞形态学变化，采用酶联免疫吸附法检测损伤的兔角膜基质细胞释放的乳酸脱氢酶含量。

RESULTS We successfully obtained human caspase-3 gene, the genes and expression vectors of reversed caspase-3 and its fusion protein with part of the translocation domain of Pseudomonas exotoxin A. Compared with the control group, the expression of both genes caused in a similar degree the decrease of living cell numbers and massive occurrence of apoptosis.

结果成功获得了caspase-3基因，构建了重构型caspase-3基因和重构型caspase-3与绿脓杆菌外毒素转膜结构域部分肽段的融合蛋白基因及其表达载体，与对照组相比，在转染后1～4 d内，两种基因的表达均导致HeLa细胞存活数减少，大量细胞发生凋亡，且二者活性相当。

Streptococcal pyrogenic exotoxin B is a cysteine protease and carried by every strain of Streptococcus pyogenes. SPE B has been shown to play an important role in invasive group A streptococcal infection.

链球菌致热性外毒素B 是一种cysteine protease，所有A群链球菌都携带致热性外毒素B之基因，在A群链球菌侵入性感染的病程中，致热性外毒素B扮演一个重要的致病角色。

"Given that such headaches are uncommon and eventually remit, the use of botulinum A exotoxin for dermatologic indications need not be curtailed," they write.

作者写道：「假如这种由A型脑肠菌毒素所引起的头痛是很少见的，并且最终是可以缓解的，那麼利用A型脑肠菌毒素作为皮肤科治疗的方法，并没有减少的需要。

"Botulinum A exotoxin injection may be associated with the development of life-altering headaches," write Murad Alam, MD, from DermSurgery Associates in Houston, and colleagues.

美国休士顿皮肤外科协会的Murad Alam医生，和他的同事们写道：「进行A型脑肠菌毒素的皮下注射，可能与发病成顽固迁延性头痛病有关，这种头痛病将会改变人的一生。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。